Development and validation of the interview version of the Hong Kong Chinese WHOQOL-BREF

Introduction. The Hong Kong Chinese version of the WHOQOL-BREF was designed as a self-administered questionnaire and has limitations in clinical application on subjects who have limitations in reading or writing. An interview version is therefore needed to avoid sampling biases in clinical studies. Since there are significant differences in the written Chinese and spoken Cantonese, which is a dialect commonly spoken among people in Hong Kong, and adaptation process for converting the written Chinese into spoken Cantonese was necessary. The interview version was designed to allow administration in both face-to-face interview and telephone interview mode. Methods. Three members of the research team translated the formal written Chinese in the self-administered version of the WHOQOL-BREF(HK) into colloquial Cantonese separately. Brief notes extracted from the facet definitions of the WHOQOL-100 were added in brackets after some questions to further explain the intention of the questions. Two series of focus groups were conducted and subsequently the field test version was produced. 329 subjects were recruited by convenient sampling method for the field test. Results. The interview version and the self-administered version was found equivalent. The ICC values of the domain scores ranged from 0.73 in the environment domain to 0.83 in the psychological domain. The face-to-face interview and telephone interview mode of administration were also found equivalent. The ICC for the domain scores ranged from 0.76 in the social interaction domain to 0.84 in the psychological domain. The other psychometric properties of the interview version were found comparable to the self-administered version. Conclusion. The self-administered and the interview version of the WHOQOL-BREF are regarded as identical in group comparison. The authors advise that it is acceptable to use different versions on different subjects in the same study, provided that the same version is applied on the same subject throughout the study.     

积极心理学干预对上消化道溃疡患者情绪及生存质量的影响

目的：探讨积极心理学干预对上消化道溃疡患者情绪及生存质量的影响。方法将62例上消化道溃疡患者随机分为两组,均予以消化内科常规治疗与护理,研究组在此基础上联合积极心理学干预。观察2周。于干预前后采用世界卫生组织生存质量测定量表简表、焦虑自评量表、抑郁自评量表及简单应对方式量表评定生存质量、情绪状态及应对方式。结果干预前两组各量表评分比较差异无显著性（P＞0．05）;干预后研究组焦虑自评量表、抑郁自评量表评分显著低于对照组（P＜0．05）,世界卫生组织生存质量测定量表简表评分显著高于对照组（P＜0．05）,积极应对维度分显著高于对照组（P＜0．05）,消极应对维度分显著低于对照组（P＜0．05）。结论对上消化道溃疡患者予以积极心理学干预能显著改善患者的情绪状态,改变其应对方式,提高患者的生存质量。     

慢性乙型肝炎患者心理健康与生存质量状况调查

目的 探讨慢性乙型肝炎患者的心理健康与生存质量状况,为临床心理干预及个体化治疗提供依据.方法 将90例慢性乙型肝炎患者设为研究组,抽取同期正常体检健康者100名设为对照组,采用症状自评量表、世界卫生组织生存质量测定简表对两组进行测评分析.结果 研究组症状自评量表总分及躯体化、强迫、人际关系、抑郁、焦虑因子分显著高于对照组(P＜0.05或0.01),世界卫生组织生存质量测定简表4个领域评分均显著低于对照组(P＜0.01).结论 慢性乙型肝炎患者存在不同程度的心理问题,生存质量较低,对患者进行常规抗病毒治疗的同时,还应关注患者的生存质量,针对患者存在的心理问题予以心理干预,对促进患者的全面康复具有重要意义.     

The World Health Organization's WHOQOL-BREF quality of life assessment: Psychometric properties and results of the international field trial. A Report from the WHOQOL Group

Quality of life (QOL) assessments that are easily administered and which do not impose a great burden on the respondent are needed for use in large epidemiological surveys, clinical settings and clinical trials. Using data from the WHOQOL-BREF field trials, the objectives of this work are to examine the performance of the WHOQOL-BREF as an integrated instrument, and to test its main psychometric properties. The WHOQOL-BREF is a 26-item version of the WHOQOL-100 assessment. Its psychometric properties were analysed using cross-sectional data obtained from a survey of adults carried out in 23 countries (n = 11,830). Sick and well respondents were sampled from the general population, as well as from hospital, rehabilitation and primary care settings, serving patients with physical and mental disorders and with respect to quotas of important socio-demographic variables. The WHOQOL-BREF self-assessment was completed, together with socio-demographic and health status questions. Analyses of internal consistency, item-total correlations, discriminant validity and construct validity through confirmatory factor analysis, indicate that the WHOQOL-BREF has good to excellent psychometric properties of reliability and performs well in preliminary tests of validity. These results indicate that overall, the WHOQOL-BREF is a sound, cross-culturally valid assessment of QOL, as reflected by its four domains: physical, psychological, social and environment.     

肝移植术改善患者生存质量的初步研究

目的：研究肝移植手术前后患者生存质量的改变情况。方法：将患者分为肝癌组和非肝癌组．采用WHOQOL-BREF表对65例患者在肝移植术前、术后1-3个月、术后4-6个月及术后6个月以上4个时间段进行生存质量的测评。结果：非肝癌组在生理领域、自身生存质量总的主观感受及对自身健康状况总的主观感受方面．肝移植术后的评分与术前相比差异有显著性意义（P〈0．05）。肝癌组在对自身健康状况总的主观感受方面上，术后评分与术前相比差异有显著性意义（P〈0．05）。结论：肝移植术可以提高患者的生存质量。     

军队疗养员生存质量及其影响因素分析

目的 了解军队疗养员生存质量现状及其影响因素。方法 采用《世界卫生组织生存质量测定量表简表(WHOQOL-BREF)》及自编的《军队疗养员一般情况调查表》对244名军队疗养员进行调查。结果 1．军队疗养员生存质量各领域得分均高于地方社区人群。2．多元回归分析显示对军队疗养员生存质量影响明显的因素为：是否患慢性病、经济状况、住房条件、邻里关系、婚姻状况。结论 军队疗养员生存质量高于普通社区人群；改善疗养员的经济状况、住房条件和邻里关系，维持良好的健康状况和婚姻关系有利于进一步提高生存质量。     

Bell's面瘫患者生存质量及影响因素研究

目的:评价Bell's面瘫患者的生存质量状况并探讨其影响因素.方法:Bell's面瘫患者316例为研究对象,采用House-Brackmann(HB)分级量表评估患者面瘫程度,世界卫生组织生存质量简表(WHOQOL-BREF)中文版评价患者生存质量;根据病程将患者分为急性期(≤72 h)及亚急性期(72～168 h),...     

齐拉西酮与碳酸锂对躁狂发作患者临床疗效和生活质量的影响

目的 探讨齐拉西酮与碳酸锂对躁狂发作患者临床疗效和生活质量的影响.方法 将120例躁狂发作患者随机分为两组,每组60例,研究组口服齐拉西酮治疗,对照组口服碳酸锂治疗,观察6个月.于治疗前及治疗第1个月、2个月、4个月、6个月末采用Beck-Rafaelsen躁狂量表评定临床疗效,世界卫生组织生存质量量表简表评定生活质量,副反应量表评定不良反应.结果 治疗后两组Beck-Rafaelsen躁狂量表总分及各因子分均较治疗前显著下降(P＜0.01),同期两组评分比较差异均无显著性(P＞0.05);治疗6个月末,研究组总有效率93.3%,对照组为91.7%,两组差异无显著性(P＞0.05).治疗后两组世界卫生组织生存质量量表简表各维度评分均较治疗前显著升高(P＜0.01),同期研究组心理领域、社会关系、环境领域维度评分均较对照组升高更显著(P＜0.01).研究组不良反应较轻微,治疗各时段副反应量表评分及不良反应发生率均显著低于对照组(P＜0.05或0.01).结论 齐拉西酮与碳酸锂治疗躁狂发作疗效显著,均能显著提高患者的生活质量,总体疗效相当,但齐拉西酮提高患者生活质量的效果更显著,不良反应较轻微,不需要常规监测血药浓度,安全性更高,优于碳酸锂治疗.     

WHOQOL—BREF在抑郁症患者中的应用分析

目的了解和评价WHOQOF—BREF在抑郁症患者中的应用情况。方法采用生存质量综合评定问卷简表（WHOQOL-BREF）进行调查,统一指导语。调查表由患者在治疗前和治疗第6周结束时独立填写或在医师指导下填写。治疗前和治疗第6周时测评汉密尔顿抑郁量（HAMD）。结果治疗前Cronbachα=0．7499,治疗后Cronbachα=0．8770。WHOQOL-BREF的第4个条目在治疗前后无变化（P〉0．05）,其余各个条目的差别均非常显著。研究前HAMD评分与生存质量主观感受呈负相关（P〈0．01）,第6周与各个因子均呈负相关（P〈0．01）。年龄、婚姻、文化和居住地不同,生存质量有差别,但治疗后差别消失。结论WHOQOLBREF在抑郁症患者具有良好的内部一致性,可用于评定患者不同时期的生存质量。