透疹解毒法治疗感染相关性寻常型银屑病疗效观察

目的：观察根据透疹解毒法自拟的透疹解毒散治疗与感染相关的寻常性银屑病的疗效。方法：将55例符合纳入标准的患者随机分为治疗组（30例）和对照组（25例）。治疗组口服解毒透疹散,每次15g,温开水冲服,每日2次;对照组口服复方青黛胶囊,每次4粒,每日3次,疗程为8周。观察治疗前后银屑病皮损积分变化及药物安全性,客观评价透疹解毒法治疗感染相关性寻常型银屑病的疗效。结果：治疗组临床治愈9例（30．00％）,好转17例（56．67％）,无效4例（13．33％）;与对照组比较差异有统计学意义（P〈0．05）。结论：透疹解毒法治疗感染相关性寻常性银屑病疗效确切。     

寻常型银屑病患者血清MMP-2、IL-18和IL-2的检测及临床意义

目的探讨MMP-2、MMP-9和IL-18在寻常型银屑病发生发展过程中的作用。方法以寻常型银屑病患者共73例(包括进行期48例、静止期25例)和健康对照58例样本为试验材料,采用双抗体夹心酶联免疫技术测定血清中MMP-2、MMP-9和IL-18浓度。结果进行期患者血清MMP-2、MMP-9和IL-18浓度均最高,分别为411.57±123.48ng/mL、681.42±297.31ng/mL和421.73±41.30ng/mL,显著高于静止期组和对照组(P<0.05)。治疗后血清中MMP-2、MMP-9和IL-18浓度分别为273.54±91.85ng/mL、431.65±120.81ng/mL和287.34±19.41ng/mL,均显著低于治疗前水平(P<0.05)。结论 MMP-2、MMP-9和IL-18因子在银屑病的发生、发展过程中起着重要作用,观察其浓度变化对探讨其发病机理,预防和指导用药均有重要的临床价值。     

寻常性银屑病患者外周血中IL-17、IL-18水平变化及其与PASI评分的相关性分析

目的:探讨lL-17、IL-18在寻常性银屑病患者外周血清中的变化及其与皮损面积和严重程度指数(PASI评分)的相关性。方法:采用双抗体夹心酶联免疫吸附法(ELISA)检测30例寻常性银屑病患者和15例健康对照者外周血IL-17和IL-18水平,并和PSAI评分相关因素进行分析。结果:30例寻常性银屑病患者与15例健康对照者比较,其外周血中IL-17、IL-18的水平明显增高,差异均有显著统计学意义(P<0.01);23例进行期寻常性银屑病患者与7例静止期寻常性银屑病患者比较,其外周血中IL-17、IL-18的水平明显增高,差异有统计学意义(P<0.05)。30例寻常性银屑病患者血清IL-17和IL-8水平与PASI评分呈正相关(r_(17)=0.739 8,P<0.001)(r_(18)=0.328 8,P<0.001)。结论:IL-17和IL-18可能与寻常性银屑病的发病有关,且与该疾病的活动性有一定的相关性。     

安体舒通治疗寻常痤疮疗效观察

本文通过103例寻常痤疮病人随机地分成三组,分别用四环素,每天1.0克;安体舒通,每天60毫克;和安体舒通与四环素并用进行观察,结果示:安体舒通疗效明显优于四环素,安体舒通与四环素并用效果极佳。治疗期间未出现任何明显的副作用。因此,安体舒通作为一种雄激素拮抗剂,短期治疗寻常痤疮是完全可靠的。     

晕可平冲剂质量标准研究

目的：建立晕可平冲剂完善的质量标准。方法：采用以夏枯草，车前草为对照药材，以熊果酸为对照品，对晕可平冲剂进行了薄层层析定性检测研究。结果：全方层析斑点清晰，特征性强；采用硅胶柱分离－分光光度法，对制剂中所含熊果酸成分进行含量测定，结果含量测定的标准品线性关系好，检测数据稳定。结论：该方法可应用于晕可平冲剂的质量检测。     

段行武教授“辨病论治”寻常型银屑病用药特点分析

以用药频率和用药剂量为着眼点,对2015年10—11月段教授治疗177例寻常型银屑病患者的用药情况进行总结,筛选出用药频率最高的16种药物,并对其用药特点进行分析,为临床治疗寻常型银屑病提供参考依据,初步建立段教授"辨病论治"临床诊疗思维模式。     

阿维A胶囊联合消银颗粒治疗寻常性银屑病60例疗效观察

目的:探讨阿维A胶囊联合消银颗粒治疗寻常性银屑病的临床疗效。方法:选取临床确诊的寻常型银屑病患者120例,随机分为观察组和对照组各60例,观察组口服阿维A胶囊10 mg,3次/d,连用45 d后减为10 mg,2次/d,并用消银颗粒3.5 g,3次/d,疗程3个月。对照组采用单用阿维A胶囊,用法同上。结果:所有患者均坚持治疗1个疗程,观察组总有效率明显优于对照组,差异有统计学意义(P<0.05)。结论:阿维A胶囊联合消银颗粒治疗寻常性银屑病疗效显著,可作为治疗此病的一个选择,并进一步观察研究。     

寻常型银屑病患者心理因素分析及护理干预

目的探究寻常型银屑病患者的心理状态及个性特征,为本病的治疗和护理提供更多的参考依据;方法采用症状自评量表（Symptom Check List90,SCL-90）调查寻常型银屑病患者的心里状态和个性特征,并于实施心理护理干预28周后做以对照比较。结果随机调查寻常型银屑病患者44例,结果干预前有29例（65．91％）存在不同程度心理障碍;SCL-90各因子分值比较显示,干预前存在躯体、强迫、人际关系、抑郁、焦虑、恐怖和偏执等心理问题,干预后有显著性改善（P〈0．05）。结论寻常型银屑病患者治疗前存在不同程度的心理障碍,表现为情绪不稳、抑郁、急躁、易怒、被动。针对不同的个性特征,给予相应的心理干预和护理对策,对提高患者的生活质量有重要意义。     

Elevated Levels of Interleukin-23 in Sera of Patients with Pemphigus Vulgaris

Background: Pemphigus vulgaris, a chronic mucocutaneous disease, is the most prevalent type of pemphigus which manifests with development of bullae and erosions on skin and mucosal membranes. Objectives: To investigate the potential role of IL-23 in pemphigus vulgaris. Methods: In this study, 30 patients with pemphigus vulgaris and 30 healthy individuals were selected according to inclusion and exclusion criteria. Measurement of IL-23 serum levels in blood samples was conducted by ELISA. Data was analyzed using Student’s t-test for comparison of IL-23 levels between the two groups. Results: Mean serum levels of IL-23 in patients with pemphigus and healthy controls were 25.1 ± 4.2 and 17.9 ± 4.7 pg/ml, respectively (p<0.05). Conclusions: Based on the findings of this study, serum levels of IL-23 were higher in patients with pemphigus in comparison to healthy individuals with no clinical significance.     

Psychological and Sexual Consequences of Psoriasis Vulgaris on Patients and Their Partners

IntroductionPsoriasis is a chronic, multisystem, inflammatory, disfiguring disease with a high negative impact on quality of life due to comorbid psychological, organic, and sexual consequences.AimTo evaluate the psychopathological and sexual aspects of psoriasis vulgaris in patients and their partners compared to healthy controls.MethodsIn the current comparative cross-sectional study, the sample included 220 psoriasis vulgaris patients (110 males and 110 females), their consenting partners, and 220 age- and sex-matched healthy controls. All participants were evaluated for depression and anxiety using the Hospital Anxiety and Depression Scale and for low self-esteem using the Rosenberg's Self-Esteem Questionnaire. Sexual function was assessed in females using the Female Sexual Function Index questionnaire and in males using the International Index of Erectile Function and its abbreviated 5-item version. For male patients suffering from erectile dysfunction, hormonal assessment and penile duplex ultrasound were added.Main Outcome MeasureThe main outcome measures were frequency of depression, anxiety, low self-esteem, and sexual dysfunction in psoriasis vulgaris patients, partners, and controls; the domains of sexual function affected in the studied groups; and the etiology of erectile dysfunction in affected psoriatic males.ResultsFrequency of depression, anxiety, and low self-esteem were significantly higher in psoriasis patients of both sexes compared with controls. Sexual dysfunction followed the same trend of being significantly higher in cases when compared to controls. Females had a significantly higher frequency of sexual dysfunction than males. Sexual dysfunction in both sexes involved multiple domains of the sexual response cycle, with depression and genital affection by psoriasis being risk factors in both sexes and disease severity being an additional risk factor in females. Erectile dysfunction was mainly psychogenic in origin in male patients.Clinical ImplicationsAssessment of psychopathological and sexual comorbidities in psoriasis patients and partners should be an integral part of the management plan and should be added to the guidelines of the disease.Strength & LimitationsThis study is of sufficient power to draw solid conclusions. Assessment of the partners and determination of the sexual domains affected by the disease and nature of erectile dysfunction in males are points of novelty. The cross-sectional design is a limitation of the study.ConclusionPsoriatic patients of both sexes and their partners suffer from a high burden of psychopathological and sexual consequences that are related to disease distribution and severity.Alariny AF, Farid CI, Elweshahi HM, et al. Psychological and Sexual Consequences of Psoriasis Vulgaris on Patients and Their Partners. J Sex Med 2019; 16:1900–1911.