Vitapex用于根尖诱导成形术的临床观察

目的：观察Vitapex糊剂用于年轻恒牙及成年人恒牙根尖诱导成形术的临床效果。方法选取四川省人民医院城东病区口腔科因外伤,龋病,畸形中央尖等致牙根发育不全伴慢性根尖周炎的患牙共24颗,依据年龄分为A、B两组。两组均采用Vitapex做根尖诱导成形治疗,术后定期复查,根尖封闭后行根管永久充填。结果 A组14颗全部成功,牙根形成类型以Ⅰ型和Ⅱ型为主,一次诱导即可完成,平均治疗周期（6.9±177;0.3）个月;B组10颗成功8颗,失败2颗,牙根形成以Ⅲ型和Ⅳ型为主,部分病例需做二次诱导治疗,平均治疗周期（13.3±177;0.2）个月。结论 Vitapex糊剂用于年轻恒牙根尖诱导成形治疗效果确切,用于成年人恒牙根尖诱导时部分病例效果较好,及早明确成年人患牙根尖病变情况有助于确定适合的治疗方案。     

碘仿氧化锌糊剂与Vitapex糊剂治疗乳牙根尖周病的疗效研究

目的:探讨乳牙根尖周病采用vitapex糊剂与碘仿氧化锌糊剂治疗效果。方法:本次选取乳牙根尖周病患者100例,随机分组,就vitapex糊剂(A组)与碘仿氧化锌糊剂(B组)效果进行比较。结果:术后3个月,A组患牙选取病例总有效率为92%,B组患牙为90%,患牙组间无明显差异(P>0.05),术后1年,A组患牙总有效率为92%,B组患牙为78%,差异有统计学意义(P<0.05)。结论:临床需采用复诊率低、无痛、快速的方法治疗儿童疾病,本次针对乳牙根尖周病患者,采用vitapex糊剂效果较为理想,值得临床广泛推广应用。     

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目的探讨Vitapex糊剂在根尖周囊肿非手术治疗中的疗效。方法选择2011年6月至2012年3月在开滦总医院康复医院确诊为根尖周囊肿10例患者,共计19颗患牙,经充分根管引流、根管预备及根管消毒后,封入Vitapex糊剂并超出根尖孔至囊肿内,待囊肿范围减小或病变区骨密度增高后,行严密根管充填。术后定期拍摄X线牙片观察6～12个月。结果10例中1例患者（1颗患牙）因自身原因退出,失败1例（2颗患牙）,其余8例（16颗惠牙）有效,有效率达88．9％。结论Vitapex糊剂根管封药加根管充填可应用于根尖周囊肿的非手术治疗。     

Influence of Calcium Hydroxide–loaded Microcapsules on Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa B Ligand Activity

Introduction

Calcium hydroxide (Ca[OH]₂) microcapsules were synthesized to allow controlled release of Ca(OH)₂. The aim of this study was to evaluate the influence of Ca(OH)₂ microcapsules on osteoprotegerin (OPG) activity, receptor activator of nuclear factor kappa B ligand (RANKL) activity, and the OPG/RANKL ratio compared with pure Ca(OH)₂ powder and Vitapex (Neo Dental Chemical Products Co Ltd, Tokyo, Japan).

Methods

One formula of Ca(OH)₂ microcapsules was evaluated, and pure Ca(OH)₂ powder was used as a control. A commonly used Ca(OH)₂ medication containing an oily vehicle (Vitapex) was also evaluated, and the in vitro release profile of Vitapex was studied. The human osteosarcoma cell line MG63 was used to evaluate the influence of Ca(OH)₂ microcapsules, pure Ca(OH)₂ powder, and Vitapex on OPG and RANKL activity. The relative messenger RNA (mRNA) expression of OPG and RANKL was determined by real-time polymerase chain reaction. The protein expression of OPG and RANKL in supernatants was measured using enzyme-linked immunosorbent assay.

Results

Vitapex prolonged the release of Ca(OH)₂ compared with pure Ca(OH)₂ powder, and the release rate of Vitapex was faster than that of the microcapsules. The OPG/RANKL ratio in the microcapsules group was up-regulated at both the mRNA and protein levels compared with the negative control group and the pure Ca(OH)₂ powder group. The ratio in the Vitapex group was lower than the microcapsule group both at the mRNA and protein levels.

Conclusions

Ca(OH)₂ microcapsules increased the expression of OPG although they did not increase the expression of RANKL compared with pure Ca(OH)₂ powder and Vitapex. This increase in expression led to an increase in the OPG/RANKL ratio and eventual inhibition of osteoclast activity.     

Vitapex糊剂和抗生素糊剂用于根尖诱导成形术的疗效比较

目的:观察两种根充糊剂对根尖诱导成形的作用。方法:选择年轻恒牙172颗,其中牙髓炎62颗、牙髓坏死32颗、根尖周炎78颗,随机分成两组,分别充填Vitapex糊剂和抗生素糊剂,随访3a评价其疗效。结果:总治疗有效率Vitapex组为86.0%,抗生素组为91.9%,差异无显著性(P>0.05);但在根尖周炎组两者差异有显著性(P<0.05)。结论:Vitapex和抗生素糊剂都是较理想的根尖诱导制剂,但Vitapex糊剂要注意适应证的选择。     

氧化锌丁香油酚糊剂和Vitapex充填乳牙根管的疗效比较

目的比较氧化锌丁香油酚(ZOE)糊剂和Vitapex两种乳牙根管充填材料的临床疗效及对乳牙牙根吸收的影响。方法选择牙髓炎或根尖周炎的乳牙81颗,随机分为2组,ZOE组(A组)和Vitapex组(B组)。常规根管预备后A组用ZOE糊剂根充,B组用Vitapex根充。术后2、4、6个月复诊,进行临床检查和X线片检查。结果A、B两组治疗后的临床表现、根充后根尖周阴影的变化均无显著性差异(P>0.05);但A组超充材料不易吸收,A、B两组有显著性差异(P<0.05)。结论ZOE糊剂和Vitapex作为乳牙根管充填材料,临床成功率相近;但ZOE糊剂存在超充后不易吸收,部分病例ZOE糊剂的吸收慢于乳牙牙根吸收。     

4种根管消毒药物对离体人牙根管内致病菌抗菌活性的研究

目的:对比氢氧化钙糊剂、碘仿糊剂、FC、Vitapex4种根管消毒药物对离体牙根管内优势致病菌的抗菌活性。方法:选取50个新鲜拔除的人单根管牙,在釉牙骨质界处切除牙冠。将所有牙根随机分为5组,每组10个。清理根管后将细菌混合悬液接种培养,10d后取样做细菌计数后进行根管预备,取样进行细菌计数,将氢氧化钙糊剂、碘仿糊剂、FC、Vitapex和无菌纸捻分别封入5组根管内,7d后再取样做细菌记数。结果:统计学分析发现:根管预备前后各组牙根根管内细菌数量存在显著性差异(P<0.05);对比封药前后根管内细菌数量发现4种药物均有抗菌作用,但4种药物的抗菌活性无显著统计学差异(P>0.05)。结论:完善的根管预备能够去除根管内的大部分致病菌,4种根管消毒药物抗菌活性无显著差异。     

Vitapex糊剂和甲醛甲酚联合碘仿治疗有瘘型根尖周炎的疗效比较

目的：探讨Vitapex糊剂和甲醛甲酚联合碘仿作为根管消毒药物治疗有瘘型根尖周炎的疗效。方法：收集158颗有瘘型慢性尖周炎的患牙,随机分为2组,研究组用Vitapex糊剂根管内封药,对照组用甲醛甲酚联合碘仿根管内封药。对2组封药后患牙疗效及对根管治疗期间急症疼痛的发生率进行比较。结果：研究组的有效率为97.47%,对照组的有效率为86.08%,研究组的临床疗效优于对照组（P〈0.05）;与对照组比较,研究组疼痛的发生率显著降低,死髓牙根管治疗期间疼痛（endodontic interappointment pain,EIP）发生率为6.33%,对照组为16.45%,差异有统计学意义（P〈0.05）。结论：Vitapex糊剂用于有瘘型根尖周炎根管内封药能有效控制感染和预防根管治疗期间疼痛的发生。     

Vitapex、派丽奥联合治疗严重根尖周炎伴牙周炎病例的疗效观察

严重根尖周炎伴牙周炎的患牙临床常予以拔除。我科采用Vitapex、派丽奥联合治疗此类患牙18例。术后观察8个月,牙槽嵴顶骨质修复,根尖周区及分叉区骨密度增高,吸收的根尖周区钙化,牙齿松动<Ⅰ度。     

Vitapex根管充填糊剂治疗老年糖尿病患者窦道型根尖周炎的疗效

目的 观察Vitapex糊剂治疗老年糖尿病患者窦道型根尖周炎,观察治疗1周后的急症反应和2年后的临床疗效.方法 选择患有糖尿病且有窦道型根尖周炎的老年患者144例的225颗患牙,常规根管预备消毒后分为2组:A组72例116颗患牙使用Vitapex糊剂加牙胶尖充填根管,B组72例109颗患牙用Cortisomol糊剂加牙...