KCl溶液诱导输尿管平滑肌收缩及其应用

目的 :用KCl溶液诱导输尿管平滑肌收缩反应 ,探讨其在测定和评估输尿管收缩功能方面的价值。　方法 :在新鲜Krebs液水浴中 ,以高浓度KCl溶液诱导离体兔输尿管段的收缩反应 ,分别测定 6只正常和 6只经碎石机冲击后家兔的输尿管标本。　结果 :94mmol/L的KCl溶液可成功地引出正常组和受冲击组输尿管段的收缩反应 ,冲击组收缩力明显低于正常组 (P <0 .0 5 )。　结论 :高浓度KCl溶液能有效地诱导离体输尿管段的收缩。这一方法可用来测定输尿管平滑肌的功能状态     

An evaluation of two Rapid Access Chest Pain Clinics in central Lancashire, UK

AIM: The aim of the project was to assess critically, using Maxwell's six dimensions, the quality of the services provided by the two Rapid Access Chest Pain Clinics (RACPCs) in Central Lancashire. METHODS: Data on the actual use of the clinic was obtained from the two RACPCs. A record linkage exercise between the database of patients from the RACPC and HES/mortality data was performed. Expected use of the clinic was established from the performance of other RACPCs and from published angina incidence figures. Patient and general practitioner views were obtained by conducting questionnaire surveys. KEY RECOMMENDATIONS: (1) Clinic is providing a valuable service and should be continued. (2) A standardized database should be created which includes ethnicity and final diagnosis. (3) Alternative methods for rapid diagnosis and management of chest pain need to be provided for patients who are not suitable for the exercise electrocardiogram. (4) Referral criteria should be redrafted in order to remove the exclusion criteria for patients with chest pain of longer duration than 3 months. (5) Further resources need to be targeted at cardiology outpatients and revascularizations, as waiting times for patients with a positive test are felt to be too long.     

Nestin expression as a new marker in malignant peripheral nerve sheath tumors

Malignant peripheral nerve sheath tumor (MPNST) can be difficult to diagnose because it lacks specific immunohistochemical markers. S-100, which is a useful marker of MPNST, has limited diagnostic utility. Recent studies suggest that nestin, which is an intermediate filament protein, is expressed in neuroectodermal stem cells. The diagnostic utility of immunostains for nestin and three other neural markers (S-100, CD56 and protein gene product 9.5 (PGP 9.5)) were evaluated in 35 cases of MPNST and in other spindle cell tumors. All MPNST cases were strongly positive for nestin and had cytoplasmic staining. Stains for S-100, CD56, and PGP 9.5 were positive in fewer cases (17/35, 11/35, and 29/35 cases, respectively), and had less extensive staining. Nestin was negative in 10/10 leiomyomas, and weak nestin expression was seen in 10/10 schwannomas, 3/10 neurofibromas, 2/8 synovial sarcomas, 2/10 liposarcomas, 4/7 carcinosarcomas and 3/7 malignant fibrous histiocytomas. In contrast, strong nestin positivity was seen in 10/10 rhabdomyosarcomas, 15/19 leiomyosarcomas, and 9/9 desmoplastic melanomas. Nestin is more sensitive for MPNST than other neural markers and immunostains for nestin in combination with other markers could be useful in the diagnosis of MPNST.     

三种不同囊袋切口的胸壁完全性植入式输液港#br# 术式对比#br#

目的比较几种不同囊袋切口的胸壁完全性植入式输液港的手术效果。方法回顾性分析2018年1月至2019年7月期间158例于广州市第一人民医院接受输液港植入术的患者资料。根据术式不同分为3组,隧道针 横切口组(n=47)、穿刺点 纵切口组(n=60)、穿刺点 横切口组(n=51),对3种术式的手术时间、术后并发症进行对比。结果3种术式中平均手术时间,隧道针 横切口组最长为(3136±110)min,其次为穿刺点 横切口组(2865±107)min,穿刺点 纵切口组最短为(2670±093)min,差异具有统计学意义(P<005)。并发症方面,隧道针 横切口组5例(104％),穿刺点 纵切口组10例(167％),穿刺点 横切口组7例(137％),差异无统计学意义(P>005)。结论穿刺点 纵切口、穿刺点 横切口两种术式操作更为简便,是锁骨下静脉胸壁完全性植入式输液港的理想术式。