射频热疗联合胸腔内注射药物治疗老年人恶性胸腔积液的临床研究

目的观察胸腔深部射频热疗联合胸腔内注射榄香烯加顺铂治疗老年人恶性胸腔积液的疗效和不良反应。方法确诊为肿瘤所致的恶性胸腔积液的老年患者75例,≥60岁,随机分为两组。采用中心静脉置管进行胸腔引流术尽可能排爆胸水,A组38例,平均年龄（70．3±2.4）岁,患者给予胸腔内注射榄香烯300mg联合顺铂30mg,每周1次。然后进行患侧胸腔深部射频热疗;B组37例,平均年龄（69．5±2．6）岁患者只给予胸腔内注射榄香烯300mg联合顺铂30mg,每周1次。结果两组总有效率,即完全缓解率＋部分缓解率为：A组86．84％,B组62．16％,两组差异有统计学意义（P〈0.05）,A组与B组生活质量好转率分别为81.58％和62．16％（P〈0.05）。结论胸腔深部射频热疗联合榄香烯加顺铂治疗老年恶性胸水有较好效果,毒副作用小,是安全有效的方法。     

体外射频热疗仪治疗非细菌性前列腺炎和前列腺痛疗效观察

目的观察体外射频热疗仪治疗慢性非细菌性前列腺炎(CAP)和前列腺痛(PD)的疗效。方法采用体外射频热疗仪治疗NPB和PB患者,射频热疗仪工作频率为433 MHz,治疗温度为47℃,每次治疗时间为30 m in,1次/d,连续治疗5次为1个疗程。一般治疗2个疗程,最多4个疗程。结果本组215例患者,显效139例(占64.7%);有效58例(占27.0%);无效18例(8.3%),总有效率为91.7%。结论体外射频热疗仪治疗NPB和PD安全,疗效好,患者无痛苦及无任何不适感。     

Thermotherapy of prostate cancer using magnetic nanoparticles: feasibility, imaging, and three-dimensional temperature distribution

OBJECTIVES: To investigate the feasibility of thermotherapy using biocompatible superparamagnetic nanoparticles in patients with locally recurrent prostate cancer and to evaluate an imaging-based approach for noninvasive calculations of the three-dimensional temperature distribution. METHODS: Ten patients with locally recurrent prostate cancer following primary therapy with curative intent were entered into a prospective phase 1 trial. The magnetic fluid was injected transperineally into the prostates according to a preplan. Patients received six thermal therapies of 60-min duration at weekly intervals using an alternating magnetic field applicator. A method of three-dimensional thermal analysis based on computed tomography (CT) of the prostates was developed and correlated with invasive and intraluminal temperature measurements. The sensitivity of nanoparticle detection by means of CT was investigated in phantoms. RESULTS: The median detection rate of iron oxide nanoparticles in tissue specimens using CT was 89.5% (range: 70-98%). Maximum temperatures up to 55 degrees C were achieved in the prostates. Median temperatures in 20%, 50%, and 90% of the prostates were 41.1 degrees C (range: 40.0-47.4 degrees C), 40.8 degrees C (range: 39.5-45.4 degrees C), and 40.1 degrees C (range: 38.8-43.4 degrees C), respectively. Median urethral and rectal temperatures were 40.5 degrees C (range: 38.4-43.6 degrees C) and 39.8 degrees C (range: 38.2-43.4 degrees C). The median thermal dose was 7.8 (range: 3.5-136.4) cumulative equivalent minutes at 43 degrees C in 90% of the prostates. CONCLUSION: The heating technique using magnetic nanoparticles was feasible. Hyperthermic to thermoablative temperatures were achieved in the prostates at 25% of the available magnetic field strength, indicating a significant potential for higher temperatures. A noninvasive thermometry method specific for this approach could be developed, which may be used for thermal dosimetry in future studies.     

Continuous low-level heat wrap therapy for the prevention and early phase treatment of delayed-onset muscle soreness of the low back: a randomized controlled trial

OBJECTIVE: To evaluate the effects of continuous low-level heat wrap therapy for the prevention and early phase treatment (ie, 0-48 h postexercise) of delayed-onset muscle soreness (DOMS) of the low back. DESIGN: Two prospective randomized controlled trials. SETTING: Outpatient medical facility. PARTICIPANTS: Sixty-seven subjects asymptomatic of back pain and in good general health (mean age, 23.5+/-6.6 y). INTERVENTIONS: Participants performed vigorous eccentric exercise to experimentally induce low back DOMS. Participants were assigned to 1 of 2 substudies (prevention and treatment) and randomized to 1 of 2 treatment groups within each substudy: prevention study (heat wrap, n=17; control [nontarget muscle stretch], n=18) and treatment study (heat wrap, n=16; cold pack, n=16). Interventions were administered 4 hours before and 4 hours after exercise in the prevention study and between hours 18 to 42 postexercise in the treatment study. MAIN OUTCOME MEASURES: To coincide with the expected occurrence of peak symptoms related to exercise-induced low back DOMS, hour 24 postexercise was considered primary. Pain intensity (prevention) and pain relief (treatment) were primary measures, and self-reported physical function and disability were secondary measures. RESULTS: In the prevention study, at hour 24 postexercise, pain intensity, disability, and deficits in self-reported physical function in subjects with the heat wrap were reduced by 47% (P<.001), 52.3% (P=.029), and 45% (P=.013), respectively, compared with the control group. At hour 24 in the treatment study, postexercise, pain relief with the heat wrap was 138% greater (P=.026) than with the cold pack; there were no differences between the groups in changes in self-reported physical function and disability. CONCLUSIONS: In this small study, continuous low-level heat wrap therapy was of significant benefit in the prevention and early phase treatment of low back DOMS.