Transverse testicular ectopla: report of three cases

Two patients who presented with a history of right inguinal hernia and a third with an impalpable left testis were found to have transverse testicular ectopia. Both testes were fixed in their own scrotum, through a modified Ombredanne operation in two patients and a subdartos pouch in one.     

输精管结扎兔睾丸IL-1与血浆睾酮变化的研究

为了探讨输精管结扎术后睾丸IL—1的活性、来源及其与睾酮变化的关系,同步检测了结扎6、25个月家兔辜丸匀浆上清IL—1活性和血浆睾酮含量,并进行了睾丸组织IL—lmRNA的原位杂交.结果表明:(1)睾丸组织匀浆上清IL-1活性以VG6为高,与SOG6比较有显著差异(P<0.01);(2)睾丸组织IL-1mRNA的原位杂交,VG6中IL-lmRNA的杂交信号明显强于其他各组,杂交信号主要分布在曲细精管内的 Sertoli细胞和生殖细胞,也见于间质中的某些细胞中;(3)血浆睾酮含量结扎术后6个月明显降低,与对照组比有显著差异(P<0.05),IL-1活性与血浆睾酮含量呈明显的负相关关系(r=-0.595,P<0.01).故推测,结扎早期睾丸炎症所引起的巨噬细胞活化和Sertoli细胞吞噬变性精子和残余体过程增强,可能是睾丸IL-1的主要来源.输精管结扎术后IL-1活性的一过性升高可能是睾酮含量下降的原因.IL-1可能作为旁分泌调节因子抑制Leydig细胞睾酮合成.     

完全型雄激素不敏感综合征的临床特征与变异

目的　总结中国完全型雄激素不敏感综合征 (CAIS)患者的基本特征和不同变异。方法　回顾性研究了 1976年 3月至 2 0 0 2年 2月北京协和医院收治的 2 8例CAIS患者的临床表现、激素测定和性腺病理结果 ,并与中国正常人群和国外文献报道的CAIS患者进行比较分析。结果　CAIS患者为女性表型 ,成年身高 (16 6 6 7±3 81)cm ,阴毛、腋毛稀少或缺如 ,有乳房发育 ,女性外阴 ,阴道呈盲端 ,深度为 (5 76± 1 6 4 )cm ,无宫颈 ;2 6 1%合并存在睾酮水平下降 ;19 2 %出现睾丸肿瘤 ,11 5 %有较大的睾丸鞘膜积液 ,19 2 %存在有发育不良的子宫。结论　CAIS临床表现较为特异 ,但仍存在异质性 ,包括存在发育不良的子宫、合并存在睾酮水平下降 ;中国CAIS患者肿瘤的发生率高于国外的报道。     

促黄体素释放激素对大白鼠睾丸的组织学和组织化学观察

用81只雄性大白鼠分为9组,分别给予LHRH-A_3 0.02μg、2μg 及200μg 三种剂量注射2天,20天及60天。在组织学上见200μg 注射20天后,睾丸开始出现抑制退化现象。200μg 注射60天后,则抑制现象更加明显。睾丸重量下降,曲细精管萎缩,生精细胞疏松脱落,精子细胞溶解,精母细胞膨大变形,形成严重生精障碍。在组织化学上,注射LHRH-A_3 200μg 60天后,可见睾丸的新陈代谢受到影响,物质的吸收及转运出现抑制,生精上皮有一定损伤,睾酮的合成增强但分泌受到障碍。提示注射LHRH-A_3 200μg 60天后,对大鼠精子生成和睾酮的分泌发生明显的抑制作用。     

3-氯丙二醇和2、3-氧丙醇合并长期、间歇给药对恒河猴及大鼠毒性作用的观察

本文介绍了3-氯丙二醇和2,3-氧丙醇合并长期间歇用药对猴及大鼠的毒性观察,结果表明,以日剂量5mg/kg 3-氯丙二醇和75mg/kg 2,3-氧丙醇合并应用,可导至大鼠可逆性不育;对猴及大鼠的内脏器官、骨髓细胞增生度及微核数量、末梢血液细胞计数、分类,以及猴的染色体常规检查未见明显影响。表明合并用药有用药量小,给药时间短、起效快、毒性低等优点。     

睾丸神经内分泌癌的临床病理分析

目的探讨睾丸小细胞神经内分泌癌的临床病理特征和生物学行为。方法回顾分析睾丸小细胞神经内分泌癌1例并复习有关文献予以讨论。结果患者术前未得到明确的病理诊断,术后2周恢复良好,痊愈出院。出院3周后右腋窝淋巴结转移,7周后全身转移死亡。病理检查：肿瘤细胞表达神经内分泌标记物神经原特异性烯醇酶、嗜铬粒蛋白A和突触素。结论睾丸小细胞神经内分泌癌是一种比较少见的高度恶性肿瘤,有独特的病理形态,早期即可发生转移,预后凶险,死亡率高。     

Effect of Ultrasound on Testicular Electrolytes (Sodium and Potassium)

The testes of 50 rats were placed in a cup filled with water and received 1 W/cm² of ultrasound for 15 min. Fluid was collected from the seminiferous tubules and rete testis of the treated and control groups at 1, 8, 12, and 24 hr intervals. Ultrasound increased the sodium concentration in the fluid of the seminiferous tubules, decreased the sodium concentration in the fluid of the rete testis, increased the potassium concentration in the fluid of the rete testis, and decreased the potassium concentration in the fluid of the seminiferous tubules.

Fourteen, slightly sedated, monkeys (Macaca fascicularis) were treated with 1/2 W/cm² of ultrasound for 30 min. Water was used as the coupling agent for seven monkeys and 3% NaCl was used as the coupling agent for the other seven monkeys. The efficacy of ultrasound treatment in reducing sperm count to zero and achieving zero motility was increased when 3% NaCl was used. Sperm count was at the level of presonication after 20 weeks when water was used as a coupling agent.     

Insensitivity of the Testis of the Musk Shrew to DICA

Oral administration of 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid (DICA) (50–500 mg/kg body wt, for 30 days) had no effect on the weight or histology of the sex organs or on the levels of protein, RNA, and DNA in the testis and of fructose in the ampullary gland. The results suggest that musk shrew testis is insensitive to DICA treatment.     

Developmental Changes in Testosterone Production by the Rat Testis in Vitro During Late Fetal Life

The age-related evolution of the in vitro capacity of the rat testis to produce testosterone and to respond to luteinizing hormone (LH) during 3 and 24 h incubation was studied from day 18.5 to day 21.5 of fetal life. Basal testosterone production by testes from 18.5-day-old fetuses was significantly higher than production by testes from 20.5- and 21.5-day-old fetuses when secretion was expressed as either per testis or per microgram of testicular protein. When maximal LH-stimulated testosterone secretion was expressed on a per testis basis, it was significantly lower for day 18.5 testes than for day 20.5 and 21.5 testes. However, when it was expressed on the basis of testicular protein content, it decreased significantly between days 18.5 and 20.5. Basal and LH-stimulated secretions displayed the same time-related decrease throughout 24 h of incubation for the three ages studied. The dose-response curves for LH showed that the sensitivity was similar for day 18.5 and 20.5 testes (ED₅₀ = 10 vs. 14 ng/mL, respectively). These results showed an age-related decrease in testicular steroidogenic capacity without a change in the coupling efficiency of LH receptor to testosterone production during late fetal life in rats.