Metachronous neurohypophysial immature teratoma occurring 10 years after total resection of pineal mature teratoma

An 18-year-old boy presented with an immature neurohypophysial teratoma occurring 10 years after total resection of a mature pineal teratoma through an occipital transtentorial approach in 1989. Thorough histological examination had revealed a mature teratoma. He developed panhypopituitarism and diabetes insipidus in 1999. Magnetic resonance imaging revealed a suprasellar tumor occupying the third ventricle. This tumor was totally resected through a frontobasal approach. Histological examination revealed an immature teratoma. This tumor occurred in a different site from the initial tumor and was considered to be de novo and thus a so-called metachronous germ cell tumor. Patients with completely resected mature teratoma require extended follow-up, including periodic magnetic resonance imaging, because of the risk of such a metachronous germ cell tumor. Received: 19 June 2000 Revised: 10 August 2000     

Lumbar spine teratoma with associated neuroendocrine tumour (NET) in a 37-year-old woman

Spinal teratoma with associated neuroendocrine tumour (NET) is a rare entity. To date there have been only three such cases reported in the literature. Information available to clinicians regarding clinical presentation, behaviour of this tumour over time, management options and follow-up, are as a consequence very limited. We present a case of a 37-year-old woman who was found to have an incidental lumbar spine teratoma with NET after presenting with a one-week history of acute lower back pain and radiculopathy. Magnetic resonance imaging (MRI) of the lumbosacral spine demonstrated an acute disc prolapse at the L4/5 level as well as incidental lesion at the L1/2 level causing effacement of the conus medullaris. Lumbar laminectomy with gross total resection of the intradural extramedullary lesion at the L1/2 level was performed with histopathology confirming the teratoma with NET. The objective of our case is to report our experience with this unique tumour and potential management implications.     

小儿卵巢肿瘤34例临床分析

目的：了解影响小儿卵巢肿瘤生存率的因素，探讨合理的治疗方案以提高治愈率。方法：３４例小儿卵巢肿瘤患儿为１９７３～１９９５年所收治，年龄４～１４岁，右侧１８例，左侧１６例，其中３例合并蒂扭转。均经手术及病理证实。良性２４例（７０．６％），恶性１０例（２９．４％）。结果：２９例获随访。２４例良性畸胎瘤术后１例复发；２例恶性畸胎瘤术后无瘤生存期分别为６年和２年；３例内胚窦瘤术后均死于肿瘤广泛转移。结论：对于良性卵巢肿瘤主张行患侧附件切除。对于Ⅰ、Ⅱ期恶性肿瘤除行患侧附件切除外，应剖视对侧卵巢，并进行活检、术后化疗及严密随访。对Ⅲ、Ⅳ期恶性卵巢肿瘤强调作根治性手术，尽可能切除原发灶及所有转移病灶，同时术后化疗，以达长期缓解。     

Tumor carcinoide de ovario asociado a un teratoma quístico maduro

Primary ovarian carcinoid tumors are uncommon neoplasias, less than 0.1% of all ovarian cancer They should be treated like ovarian tumors of low malignity. We present a case associated with mature cystic teratoma in a patient of 88 year old with history of diarrhea and had loss of weight     

CT对卵巢良性囊性畸胎瘤的诊断价值(附21例分析)

目的：探讨卵巢良性囊性畸胎瘤的CT表面特点及其诊断价值。方法：分析21例经手术病理证实的卵巢成熟性囊性畸胎瘤的CT及B超资料，讨论CT表现特点与病理的关系。结果：21例囊性畸胎瘤均显示脂肪密度区。11个“浮球征”，9个脂液平面，10个囊壁钙化呈点状、条块状，4个分房间隔内钙化，2个囊内骨化影和软组织混杂密度影,3个未见钙化影。5例发生蒂扭转。结论：CT能显示良性囊性畸胎瘤的特殊表现，反映其病理特点。     

Integrated Expression of Circulating miR375 and miR371 to Identify Teratoma and Active Germ Cell Malignancy Components in Malignant Germ Cell Tumors

Active germ cell malignancies express high levels of specific circulating micro-RNAs (miRNAs), including miR-371a-3p (miR371), which is undetectable in teratoma. Teratoma markers are urgently needed for theselection of patients and treatments because of the risk of malignant transformation and growing teratoma syndrome. To assess the accuracy of plasma miR375 alone or in combination with miR371 in detecting teratoma, 100 germ cell tumor patients, divided into two cohorts, were enrolled in a prospective multi-institutional study. In the discovery cohort, patients with pure teratoma and with no/low risk of harboring teratoma were compared; the validation cohort included patients with confirmed teratoma, active germ cell malignancy, or complete response after chemotherapy. The area under the receiver operating characteristic curve values for miR375, miR371, and miR371-miR375 were, respectively, 0.93 (95% confidence interval [CI]: 0.87–0.99), 0.59 (95% CI: 0.44–0.73), and 0.95 (95% CI: 0.90–0.99) in the discovery cohort and 0.55 (95% CI: 0.36–0.74), 0.74 (95% CI: 0.58–0.91), and 0.77 (95% CI: 0.62–0.93) in the validation cohort. Our study demonstrated that the plasma miR371-miR375 integrated evaluation is highly accurate to detect teratoma.Patient summaryThe evaluation of two micro-RNAs (miR375-miR371) in the blood of patients with germ cell tumors is promising to predict teratoma. This test could be particularly relevant to the identification of teratoma in patients with postchemotherapy residual disease.     

Fetus in fetu of the face

A fetus in fetu of the face is described. The preoperative diagnosis was teratoma. The resected specimen weighed 200 g and had two parts. The lateral part was enclosed within a thick capsule and consisted of a well-formed lower limb, a spinal column comprised of 3 vertebrae, and a small piece of intestine in the form of a saccule. The medial part contained fibrofatty tissue only. The developmental etiology of this phenomenon and its relationship to teratoma are discussed.     

Intrapericardial teratoma causing nonimmune hydrops fetalis and pericardial tamponade: A case report

Summary A case of fetal anasarca secondary to an intrapericardial teratoma is reported. The clinical, echocardiographic, and histologic features are described, along with a review of intrapericardial lesions.     

Intrapericardial teratoma diagnosed prenatally in a twin fetus

Prenatal diagnosis at 32 weeks' gestation of an anteromediastinal tumor in a twin fetus allowed immediate neonatal intensive management after delivery at 34 weeks' gestation. At 48 h of age the patient underwent a median sternotomy; complete resection of the tumor was possible. Histologically, it was a mature teratoma. At age 1 year both twins are well. Accepted: 26 May 1998