宣肺逐痰化瘀汤治疗喘息型支气管炎慢性迁延期149例

目的：观察自拟方宣肺逐痰化瘀汤治疗喘息型支气管炎慢性迁延期的疗效。方法：149例喘息型支气管炎慢性迁延期患者随机分为两组。治疗组75例予宣肺逐痰化瘀汤口服,每日1剂煎服,每日3次;对照组74例给予阿莫西林0．5 g,氨茶碱0．25 g,沐舒坦30 mg,均每日3次治疗。两组均于治疗后测定血气分析并进行疗效判断。结果：治疗组疗效优于对照组（P ＜ 0．05）。结论：喘息型支气管炎慢性迁延期患者采用具有宣肺平喘,逐痰化瘀,兼补益肺脾功效的宣肺逐痰化瘀汤疗效显著,用药安全。     

双波长薄层扫描法测定瘫复康胶囊中黄芪甲苷的含量

目的 :对瘫复康胶囊中主要成分黄芪甲苷进行定量分析。方法 :采用双波长薄层扫描法 ,λS=52 0nm ,λR =6 50nm。结果 :平均加样回收率为 97.9% ,RSD为 3.0 %。结论 :方法较简便 ,结果稳定 ,重现性好 ,所选展开剂用于黄芪甲苷含量测定为首次报道 ,可为建立同类制剂的质量标准提供参考。     

缬沙坦治疗慢性充血性心力衰竭疗效观察

目的：观察缬沙坦治疗慢性充血性心力衰竭疗效.方法： CHF患者85例,随机分两组.对照组给予常规治疗,治疗组在常规治疗组的基础上给予缬沙坦,观察3个月.结果：经3个月的治疗,观察组总有效率为88.9%,对照组总有效率为70.0%,两组间比较差异有统计学意义（P〈0.05）.结论：缬沙坦在治疗慢性充血性心力衰竭时对患者的心率、血压、心功能、左室内径及射血分数方面均有明显改善.     

小柴胡汤对鼠实验性肝纤维化的影响

为探讨小柴胡汤对鼠肝纤维化的抑制作用，腹腔分别注射二甲基亚硝基胺和猪血清复制两种肝纤维化动物模型。预防和治疗性投与小柴胡汤可促进肝维生素A含量恢复，降低肝胶原含量和明显抑制肝前α－Ⅰ型胶原的基因表达。同时免疫组化染色证实小柴胡杨可显著减少Ⅰ、Ⅲ型胶原在肝脏沉积和明显减少α-平滑肌原纤维阳性的伊东细胞（ItoCell）的数目。结果显示小柴胡汤可防治鼠肝纤维化的发生与发展。     

痰热清对新生大鼠高氧肺损伤的影响

目的:探讨痰热清注射液对新生大鼠高氧肺损伤的影响。方法:选用生后2天的Wistar大鼠乳鼠90只随机分为高氧组、治疗组、正常组,高氧组与治疗组制备成高氧肺损伤模型,治疗组制备模型后腹腔注射痰热清注射液。各组模型制备后的第3、7、14天时随机分批处死大鼠,取肺组织,行HE染色观察肺的发育程度,并行免疫组织化学染色,对肺组织中转化生长因子β1、转化生长因子βⅠ、Ⅱ型受体行定位、半定量评分,对肺巨核细胞行细胞计数,将各组的测定值进行比较分析。结果:高氧组肺组织中转化生长因子β1、转化生长因子βⅠ、Ⅱ型受体的表达明显强于正常组、痰热清组,有显著性差异(P<0.01)。高氧组的肺巨核细胞计数少于正常组、痰热清组,有显著性差异(P<0.01)。结论:痰热清注射液在新生大鼠高氧肺损伤时对肺组织有保护作用,对支气管—肺发育不良有一定的预防作用。     

补脑振痿胶囊治疗缺血性中风后遗症的临床研究

补脑振瘘胶囊根据张锡纯所创汤剂,研制出的一种新剂型。用于治疗缺血性中风后遗症30例,并与偏瘫复原丸治疗的20例对比研究。结果显示：补脑振瘘胶囊组临床痊愈、显效、有效及有效率均高于偏瘫复原丸组,且治疗效果随疗程的增加而递增,对病程较长的患者疗效明显优于偏瘫原复丸组,肌力改善情况明显优于偏瘫复原丸组。     

丹参酮ⅡA通过诱导C/EBPβ表达促进人源NB4和MR2细胞系分化

目的探索在丹参酮ⅡA(TanⅡA)诱导NB4和MR2细胞分化过程中C/EBPβ(CAAT/enhancer-bindingproteinβ)的表达。方法用TanⅡA干预NB4和MR2细胞120 h,通过形态学和膜表面标志检测NB4和MR2细胞的分化情况明确TanⅡA对NB4和MR2细胞的分化效应;0,0.1,1和10 mg/L TanⅡA干预NB4和MR2细胞,通过RT-PCR及Western blot测定C/EBPβRNA和蛋白水平表达的变化确定C/EBPβ与TanⅡA浓度的关系;通过膜表面标志检测NB4和MR2细胞的分化情况明确TanⅡA浓度与NB4和MR2细胞分化间的关系。结果 TanⅡA能诱导NB4和MR2细胞分化(P<0.05);TanⅡA能从RNA和蛋白水平诱导C/EBPβ表达升高并与浓度成正相关(P<0.05);TanⅡA能通过非剂量依赖的模式诱导NB4和MR2细胞分化,其引起最大分化效果的浓度为1 mg/L。结论 TanⅡA能有效促进NB4和MR2细胞分化;TanⅡA通过上调C/EBPβ的表达发挥分化效应;TanⅡA最强作用浓度为1 mg/L。     

左氧氟沙星联合痰热清注射液治疗急性气管-支气管炎疗效观察

目的：观察左氧氟沙星联合痰热清注射液治疗急性气管-支气管炎的临床疗效。方法：将近年来本院收治的急性气管-支气管炎患者104例随机分为治疗组与对照组,两组各有52例,对照组以盐酸左氧氟沙星注射液治疗,观察组在此基础上加以痰热清注射液治疗,比较两组患者的临床疗效。结果：治疗1个疗程后,治疗组有效率为94.23%,高于对照组的65.38%,差异有统计学意义,P〈0.05。结论：左氧氟沙星联合痰热清注射液治疗急性气管-支气管炎效果确切,显著优于单纯左氧氟沙星治疗,值得临床推广应用。     

A WRIST-WALKER EXHIBITING NO “UNER TAN SYDNROME”: A THEORY FOR POSSIBLE MECHANISMS OF HUMAN DEVOLUTION TOWARD THE ATAVISTIC WALKING PATTERNS

After discovering two families with handicapped children exhibiting the “Uner Tan syndrome,” the author discovered a man exhibiting only wrist-walking with no primitive mental abilities including language. According to his mother, he had an infectious disease with high fever as a three months old baby; as a result, the left leg had been paralyzed after a penicilline injection. This paralysis most probably resulted from a viral disease, possibly poliomyelitis. He is now (2006) 36 years old; the left leg is flaccid and atrophic, with no tendon reflexes; however, sensation is normal. The boy never stood up on his feet while maturing. The father forced him to walk upright using physical devices and making due exercises, but the child always rejected standing upright and walking in erect posture; he always preferred wrist-walking; he expresses that wrist-walking is much more comfortable for him than upright-walking. He is very strong now, making daily body building exercises, and walking quite fast using a “three legs,” although he cannot stand upright. Mental status, including the language and conscious experience, is quite normal. There was no intra-familiar marriage as in the two families mentioned earlier, and there is no wrist-walking in his family and relatives. There were no cerebellar signs and symptoms upon neurological examination. The brain-MRI was normal; there was no atrophy in cerebellum and vermis. It was concluded that there may be sporadic wrist-walkers exhibiting no “Uner Tan Syndrome.” The results suggest that the cerebellum has nothing to do with human wrist-walking, which may rather be an atavistic trait appearing from time to time in normal individuals, indicating a live model for human reverse evolution. It was concluded that pure quadrupeds may sporadically appear due to random fluctuations in genotypes and/or environmental factors (hormonal or nutritional); the human development following the human evolution may be stopped in the stage of transition from quadrupedality to bipedality. That is, the activity of the philogenetically youngest supraspinal centers for bipedal walking responsible for suppression of the older supraspinal centers for quadrupedal gait may be interrupted at the atavistic level due to genetic and/or environmental factors. Consequently, it is assumed that these individuals prefer their natural wrist-walking to move around more quickly and efficiently.