厄贝沙坦对2型糖尿病肾病微量蛋白尿的疗效观察

目的：观察厄贝沙坦对2型糖尿病肾病微量蛋白尿的疗效。方法：选择2008年6月至2009年12月昭苏县人民医院60例确诊的早期2型糖尿病肾病微量蛋白尿患者随机分为2组,两组在控制饮食、运动疗法外,对照组30例按常规剂量口服降糖药或皮下注射胰岛素,治疗组30例给予常规剂量口服降糖药或皮下注射胰岛素外,再加上厄贝沙坦口服,疗程观察12个月。结果：治疗纽加用厄贝沙坦后尿微量蛋白明显低于对照组,结果差异有统计学意义。结论：口服降糖药或皮下注射胰岛素控制血糖的同时加用厄贝沙坦,可减少早期2型糖尿病患者微量蛋白的排泄,同时还有保护肾脏的功能。     

痰热清注射液对脓毒症小鼠免疫系统影响的研究

目的:观察痰热清注射液对脓毒症小鼠免疫系统细胞因子的影响,并探讨其作用机制,方法:采用盲肠结扎并穿刺术(CLP)制作小鼠脓毒症模型,将成年雄性BALB/c小鼠随机分为6组:假手术组,CLP手术组、阳性药物组(甲基强的松龙),痰热清大、中、小剂量组。以流式细胞微球阵列法检测外周血细胞因子水平,收集样本后计数胸腺和脾脏淋巴细胞,测定T及B淋巴细胞的增殖功能。结果:CLP导致模型小鼠血清TNF-α、IL-1β、IL-6表达水平明显上升,小鼠胸腺和脾脏萎缩明显,淋巴细胞计数和T及B淋巴细胞的增殖功能均下降,而痰热清和甲强龙处理后能有效减少炎性细胞因子反应;缓解胸腺和脾脏萎缩,3种剂量痰热清均对胸腺及脾脏淋巴细胞的超敏反应有不同程度的阻抑作用,直接刺激T,B淋巴细胞的增殖。结论:痰热清能够有效阻抑脓毒症状态下免疫系统的炎症反应,对脓毒症小鼠有明显的保护作用。     

祛痰宁的抗炎,止咳,平喘作用

祛痰宁0.10—0.40g/kg ig给药能明显抑制鸡蛋清引起的大鼠足肿胀;0.05—0.20g/kg ip及0.10—0.40g/kg ig给药时,对巴豆油引起的小鼠耳肿胀有极强的抑制作用;0.10—0.40g/kg ig给药对浓氨水引起的小鼠咳嗽也有明显的抑制作用,但平喘作用不明显;昆明种小白鼠LD_(50)ig为4.64±0.84g/kg,ip为0.58±1.18g/kg。     

Evaluating the Effect of Comprehensive Intervention on Cerebro-Vascular Function in Population at High Risk of Stroke

Background: Today there exists few intervention researches on cerebro-vascular function in populations at high risk of stroke in China. Methods: Patients more than 40 years old, with at least 1 of stroke risk factors were recruited from outpatient department in 3 hospitals. A quasi-experimental design was performed by assigning participants into 3 groups: comprehensive intervention group, health education group, and control group. Participants in the control group received no intervention but were informed of risk factors of stroke. For health education group, a health education class was performed. Except to the health education program, participants in the comprehensive intervention group received an additional health life and behavior guidance. Results: After the intervention, the Cerebro-Vascular Function Scores (CVFS) had significant differences among 3 groups (F = 5.252, P < 0.05). There was a significant increase in CVFS compared to the control group (P = 0.003, 95%CI: 1.552-8.493). Significantly changes in obesity were observed in comprehensive intervention group before and after the intervention (χ² = 9.0747, P = 0.0026). The results of logistic regression showed that comprehensive intervention group had a significant decrease in prevalence of obesity (OR = 0.482, 95% CI: 0.242-0.961) compared to the control group. Conclusion: Health education on stroke in a high-risk population combined with guidance on proper health life and behavior can be effective in preventing stroke.     

慢性肺痈中医诊疗方案再探

王檀教授认为,支气管扩张症当从肺痈进行论治,根据其反复发作的临床特点,当属于慢性肺痈的范畴,多由感染肺热病、肺痨病、小儿麻疹、哮病、肺胀等疾病后迁延不愈所致,以正气不足,肺体受损,痈毒留滞为病机关键。临证根据热毒转盛期、邪减正虚期证候特点辨证论治;缓解期应四诊合参进行辨别,总体治则为急性期清热泻火解毒;平稳期益气养阴或培土生金。此外,预后调养也决定着疾病的转归。     

加减苍附导痰汤联合减肥治疗肥胖型多囊卵巢综合征的疗效观察

目的:评价加减苍附导痰汤联合减肥疗法治疗肥胖型多囊卵巢综合征(PCOS)的临床疗效。方法:选择肥胖型PCOS患者60例,随机分为研究组(30例)和对照组(30例),研究组患者实施减肥疗法联合服用以苍附导痰汤为主的中药治疗,对照组患者仅服用加减苍附导痰汤为主的中药治疗,两组患者均治疗6个月,观察比较两组患者治疗前与治疗后一个月的月经情况、性激素水平(FSH、LH、T)、胰岛素、体重指数、腰围、臀围等。结果:研究组患者在减轻体重的同时,还可显著改善内分泌环境,更有效地调节月经周期,促进排卵,疗效优于对照组。结论:加减苍附导痰汤联合减肥疗法治疗肥胖型多囊卵巢综合征疗效显著,值得临床推广。     

文化品牌在医院文化传承与创新中的功能作用：以新华TV为例

目的：通过探索文化品牌新华TV在医院文化传承与创新中更加有效的功能作用,从而加强医院文化建设,促进医院可持续发展。方法：通过问卷调查法、座谈法与访谈法等研究新华TV在医院文化传承与创新中的功能作用。结果：目前新华TV在受众面、制作团队组成、发挥的作用等方面取得了一定成果,但仍然存在一些不足。结论：探索建立神经反射弧机制、合理扩大受众范围、探索团队四维模式,使新华TV成为医院文化传承与创新的还原剂、润滑剂和氧化剂。