氯沙坦治疗轻中度高血压病疗效观察

目的：观察氯沙坦降压疗效及不良反应。方法：选择56例轻、中度高血压患者,给予氯沙坦50～100mg／d,疗程8周,采用自身对照方法观察患者服用氯沙坦后血压变化、生化指标及不良反应。结果：治疗8周后收缩压、舒张压降低有显著差异性（P〈0．05）。其中显效44例（78．57％）,有效8例（14．28％）,无效4例（7．14％）,总有效率为92．85％。不良反应（5．35％）发生率低。结论：氯沙坦是治疗轻、中度高血压安全、有效、不良反应轻微的理想药物。     

谭新华教授从肝肾论治勃起功能障碍经验浅析

男性勃起功能障碍,中医称为阳痿,随着社会压力的增大,在年轻男性中发病率逐年上升.谭新华教授认为肝、肾二脏的功能失调是导致年轻男性勃起功能障碍的主要原因.治疗用药上常以肝肾为本、两者兼顾,寒温并用、通补兼施,以及注重对患者的心理疏导,各方面综合治疗,在临床治疗中均取得较好的疗效.     

谭新华治疗乳腺癌术后上肢淋巴水肿经验

本文介绍谭新华教授治疗乳腺癌术后上肢淋巴水肿的经验。谭老认为,乳腺癌术后上肢淋巴水肿的基本病机为正气亏虚,毒瘀内结,瘀血化水。治以益气活血为主,兼搜风通络,参以引经药直达病所;并强调需权衡虚实轻重主次,主张内服与外治相结合,方可收到较好疗效。     

An update on obesity: Mental consequences and psychological interventions

Besides physical consequences, obesity has negative psychological effects, thereby lowering human life quality. Major psychological consequences of this disorder includes depression, impaired body image, low self-esteem, eating disorders, stress and poor quality of life, which are correlated with age and gender. Physical interventions, mainly diet control and energy balance, have been widely applied to treat obesity; and some psychological interventions including behavioral therapy, cognitive behavioral therapy and hypnotherapy have showed some effects on obesity treatment. Other psychological therapies, such as relaxation and psychodynamic therapies, are paid less attention. This review aims to update scientific evidence regarding the mental consequences and psychological interventions for obesity.     

The national economic burden of eating disorders in Wales: a clinical population data study

BackgroundEating disorders have the highest morbidity of all mental disorders in the UK and can require admission to hospital. We aimed to provide whole system quantification of inpatient admission and general practitioner (GP) contact costs to the National Health Service (NHS) for patients with eating disorders in Wales.MethodsThe Secure Anonymised Information Linkage (SAIL) databank contains 84% of all electronic data obtained by NHS Wales General Practices since 1990 and all NHS hospital admissions data for Wales recorded since 1998. We obtained data on hospital admissions between Jan 1, 1998, and June 30, 2017, and GP contacts between July 1, 1990, and June 30, 2017, for patients with eating disorders, diagnosed using International Classification of Diseases (ICD)-9 and ICD-10 codes or GP Read Codes in GP or inpatient records and for a matched control cohort. We calculated total costs of hospital admissions and GP contacts between 1990 and 2017, using published unit costs for these patients, irrespective of year of diagnosis.FindingsBetween July 1, 1990, and June 30, 2017, 15 558 individuals were diagnosed with eating disorders within SAIL. 4707 individuals had complete GP records for the 2 year period before and 3 year period after diagnosis and were matched to four controls each. 4222 individuals within the case cohort had a total of 35 849 admissions with total admission costs of £81 218 113 (£17 254 751 per 1000 individuals) over 20 years between Jan 1, 1998, and June 30, 2017. By contrast, in the control cohort, 13 419 individuals were admitted to hospital with a total cost of £39 305 793 (£2 089 845 per 1000 individuals) for the same 20-year period. The cost of GP contacts over 27 years between July 1, 1990, and June 30, 2017, was £177 406 330 (£37 689 894 per 1000 individuals) for the eating disorder cohort (n=4707) and £321 041 292 (£17 069 401 per 1000 individuals) for patients in the control group (n=18 808).InterpretationEating disorders result in high costs to the NHS, particularly for hospital admissions. Therefore, greater investment in prompt recognition and early intervention for individuals with eating disorders, which greatly shorten duration of illness, are likely to be economically justifiable.FundingHealth and Social Care Wales.     

丹参酮B钠盐对局灶性脑缺血/再灌注大鼠海马神经元的保护作用

目的：研究丹参酮B钠盐对局灶性脑缺血再灌注损伤大鼠海马神经元的保护作用。方法：应用线栓法可逆性的阻塞大鼠大脑中动脉,制备大鼠局灶性脑缺血再灌注损伤模型。复灌24h后对大鼠进行神经学评分,并测定脑梗死率和含水量。制备脑组织病理切片,观察丹参酮B钠盐对局灶性脑缺血再灌注损伤大鼠海马组织病理学影响。结果：丹参酮B钠盐能使缺血再灌注后大鼠的神经行为明显改善,显著降低脑梗死率和含水量。脑组织切片病理学检查表明丹参酮B钠盐对缺血再灌注损伤大鼠海马具有明显保护作用。结论：丹参酮B钠盐对大鼠局灶性脑缺血再灌注损伤大鼠海马神经元具有很好的保护作用。     

痰热清注射液对脓毒症小鼠免疫系统影响的研究

目的:观察痰热清注射液对脓毒症小鼠免疫系统细胞因子的影响,并探讨其作用机制,方法:采用盲肠结扎并穿刺术(CLP)制作小鼠脓毒症模型,将成年雄性BALB/c小鼠随机分为6组:假手术组,CLP手术组、阳性药物组(甲基强的松龙),痰热清大、中、小剂量组。以流式细胞微球阵列法检测外周血细胞因子水平,收集样本后计数胸腺和脾脏淋巴细胞,测定T及B淋巴细胞的增殖功能。结果:CLP导致模型小鼠血清TNF-α、IL-1β、IL-6表达水平明显上升,小鼠胸腺和脾脏萎缩明显,淋巴细胞计数和T及B淋巴细胞的增殖功能均下降,而痰热清和甲强龙处理后能有效减少炎性细胞因子反应;缓解胸腺和脾脏萎缩,3种剂量痰热清均对胸腺及脾脏淋巴细胞的超敏反应有不同程度的阻抑作用,直接刺激T,B淋巴细胞的增殖。结论:痰热清能够有效阻抑脓毒症状态下免疫系统的炎症反应,对脓毒症小鼠有明显的保护作用。     

宁夏滩羊KAP1．1基因多态性及其与二毛裘皮重要性状关系的研究

目的：研究宁夏滩羊KAP1．1基因的遗传多态性及其多态位点与滩羊二毛毛股弯曲数、纤维直径及毛股自然长度的关系,寻找可用于辅助选择的分子标记,为下一步分子育种提供理论依据。方法：采用PCR—SSCP技术研究了261只滩羔羊KAPl．1基因的多态性,利用DPS7．05软件分析了2个多态位点不同基因型裘皮性状的最小二乘均值（LSM）,并进行了多重比较。结果：发现KAPl．1基因有两个突变位点sl和s2,其中s1位点有3个基因型,S2位点有5个基因型。在二毛裘皮毛股弯曲数性状上,S1-AA的LSM高于S1-AB、S1-BB,但三种基因型阃无显著差异（P〉0．05）,S2-AB的LSM高于S2-AA、S2-BB、S2-AC、S2-DD,但五种基因型间无显著差异（P〉0．05）;在毛股自然长度性状上,S1-AB的LSM显著高于S1-BB（P〈0．05）,S2-A基因型的LSM板显著高于S2-BB（〈．）;在毛纤维细度性状上,S1-AA的低于S1-AB、．CP001LSNABs1一BB,但三种基因型阃无显著差异（P〉0．05）。结论：本研究发现了宁夏滩羊KAP1．1基因的两个多肽位点S1和S2,其中S1位点有3个基因型,而s2位点有5个基因型,处于高度多态（PIC=0．7078）和高度杂合（h=0．7078）,该位点上遗传多样性很丰富,在品系培育上选择潜力很大;S1位点的AB基因型和s2位点的AC基因型都与滩羊二毛皮的毛股自然长度有明显关系,可作为分子标记用于二毛裘皮较长毛股自然长度潍羊品系定向选育。     

BiPAP无创通气联合痰热清注射液治疗慢性阻塞性肺疾病急性呼吸衰竭疗效观察

目的探讨BiPAP无创通气联合痰热清注射液治疗慢阻肺急性呼衰的临床疗效。方法83例慢性阻塞性肺病急性加重期并发Ⅱ型呼吸衰竭的患者按照入院先后顺序随机分为3组：A组（常规治疗组27例）、B组（在常规治疗组基础上加用BiPAP无创通气28例）、C组（在B组基础上联合痰热清注射液治疗28例）。常规组以消炎、祛痰、平喘、抗感染及持续低流量吸氧对症支持治疗,无创通气组通气模式为压力支持（PSV）加呼气末正压（PEEP）,C组在B组治疗基础上同时给予痰热清注射液20 ml加入5%葡萄糖注射液250 ml静脉滴注,1次/d,疗程10 d。观察3组患者治疗前与治疗后2 h、48 h血气分析、呼吸频率、心率及转归情况比较。结果无创通气加痰热清注射液组在治疗后2 h及48 h后PaO2、PaCO2、pH和呼吸、心率均明显改善（P〈0.05）,而常规治疗组无明显改善。结论 BiPAP无创通气联合痰热清注射液治疗慢阻肺急性加重期并发Ⅱ型呼吸衰竭能明显改善临床症状,降低死亡率,值得临床推广和应用。