“偏瘫宁”制剂及其临床应用

目的：观察中西药配伍合剂“偏瘫宁”治疗缺血性脑血管病的临床疗效。方法：对300例缺血性脑血管病患者进行了“偏瘫宁”疗效观察，并与采用脉通治疗的30例结果对比，结果：临床症状和肌力恢复程度，治疗后有明显改善，总有效率为96．7％，而对照组脉通治疗的有效率为80．0％，两者相对比，有显著性差异（P＜0．05），结论“偏瘫宁”对缺血性脑血管病有较好的临床疗效，毒副作用小，可推荐临床应用。     

Child Food Insecurity Is Associated with Energy Intake among Fourth- and Fifth-Grade Girls

BackgroundFood insecurity is associated with poor diet and obesity among adult women, but evidence among children is mixed, and few studies have examined differences between boys and girls.ObjectiveThis study examined the relationship between self-reported food insecurity and dietary intake among boys and girls.DesignCross-sectional survey data were used from the Children’s PowerPlay! Campaign evaluation.Participants and settingIn all, 3,547 fourth- and fifth-grade students (9 to 11 years old) from 44 San Diego-area elementary schools in 2012 completed diary-assisted 24-hour recalls and a questionnaire that included five questions from the Child Food Security Assessment.Main outcome measuresIndividual dietary components (including total energy, nutrients, and sugar-sweetened beverages), Healthy Eating Index-2010 scores, and meal patterns (such as meal sizes and missed meals) were derived from 24-hour recalls.Statistical analysesMultivariable linear and logistic regression models were used to estimate the relationships between food insecurity and diet characteristics.ResultsGirls with the highest food insecurity consumed 135 total kilocalories (P<0.005) and 60 snack kilocalories (P<0.05) more per day than girls with no food insecurity. These relationships were absent among boys.ConclusionsFood insecurity among girls in grades 4 and 5 was associated with higher energy intake. Findings support the need for further research to better understand the nature of this relationship and its implications for energy balance.     

艾灸配合苍龟探穴针刺治疗神经根型颈椎病疗效观察

目的观察艾灸配合苍龟探穴针刺治疗神经根型颈椎病的临床疗效。方法将60例神经根型颈椎病患者随机分为治疗组和对照组,每组30例。治疗组采用艾灸配合苍龟探穴针刺治疗,对照组采用单纯针刺治疗。治疗2个疗程后,观察两组治疗前后症状体征积分,并比较两组临床疗效。结果治疗组总有效率为90.0%,对照组为83.3%。两组疗效比较,差异具有统计学意义(P0.05)。两组治疗后症状体征积分与同组治疗前比较,差异均具有统计学意义(P0.05)。治疗组治疗后症状体征积分与对照组比较,差异具有统计学意义(P0.05)。结论艾灸配合苍龟探穴针刺是一种治疗神经根型颈椎病的有效方法。     

Persistent neutrophil dysfunction in an adult. Combined defect in chemotaxis, phagocytosis and intracellular killing

Impaired phagocytosis and killing of bacteria by neutrophils were demonstrated repeatedly in a 65 year old man. He had staphylococcal pyarthrosis and osteomyelitis. Phagocytosis and intracellular killing of Staphylococcus aureus by neutrophils of the patient were impaired, but no significant defect was noted when Candida was used as the test organism. Production of ¹⁴CO₂ from glucose-1-¹⁴C, glucose-6-phosphate dehydrogenase levels, nitroblue tetrazolium reduction test and myeloperoxidase levels were all normal in his neutrophils. The monocyte bactericidal capacity for Staph. aureus was normal. Despite normal migration demonstrated by the skin window technic and by the presence of numerous neutrophils in the joint aspirate, studies of neutrophil chemotaxis revealed an impaired response to chemotaxin, and an inhibitor of chemotaxis of normal neutrophils was also found in his serum. However, his serum generated chemotaxin normally. This neutrophil dysfunction appears to differ from that found in chronic granulomatous disease of childhood and other known defects of neutrophil function.     

谭新华教授辨治精囊炎经验

谭新华,教授,主任医师,博士研究生导师,享受国务院政府特殊津贴专家,湖南省名中医,全国首批、第三批老中医药专家学术经验继承工作指导老师。从事中医医疗、教学、科研工作50余年。治学重理论与实践结合,衷中参西;倡笃学务实,法古纳新;医德高尚、医术精湛,擅长外科疑难杂病的诊治,尤其对男科疾病的中医药诊治有较深研究和造诣。精囊炎是男性较常见的感染性疾病之一,病因病机复杂,缠绵难愈,谭师对于精囊炎的诊疗,疗效卓著,现将其诊疗经验介绍如下。     

藏药——三味檀香散药理学研究进展

三味檀香散由广枣、檀香、肉豆蔻3味药组成,是藏医及蒙医治疗心热病的常用方。对其进行深入研究具有现实的临床及开发意义。本文从药效学、药代动力学、毒理学三方面综述三味檀香散的研究进展。     

丹参酮ⅡA对肠缺血再灌注大鼠肺损伤的保护作用

目的：研究丹参酮ⅡA（tanshinone ⅡA）对肠缺血再灌注的大鼠肺损伤的保护作用及其可能的作用机制。方法：采用肠系膜上动脉夹闭 1 h-灌注 2 h 的方式复制肠缺血再灌注（ischemia reperfusion,IR）大鼠损伤的模型;将 SD 大鼠随机分为假手术组、模型组及丹参酮ⅡA （5,10,20 mg/kg ）组,各组于缺血前 20 min 舌下静脉给药,测定再灌注后大鼠血清及肺组织中 SOD 活力、MDA 和 NO 水平,并在光镜下观察肺组织形态学的变化。结果：模型组与假手术组相比,前者大鼠血清及肺组织中的 SOD 活力降低,MDA 和 NO 水平升高,经镜检发现大鼠肺脏组织中有明显的组织形态学的损伤;丹参酮ⅡA 组与模型组相比,前者呈剂量依赖性地增强大鼠 SOD 活力,降低 MDA 及 NO 水平,减轻大鼠肺组织中形态学的损伤。结论：丹参酮ⅡA对肠 IR 所致肺组织损伤有显著的剂量依赖性地保护作用,可能与其自由基清除作用、减轻中性粒细胞聚集及活化、抑制大量 NO释放有关。