小儿麻甘颗粒联合布地奈德治疗小儿毛细支气管炎的临床研究

目的 探讨小儿麻甘颗粒联合吸入用布地奈德混悬液治疗小儿毛细支气管炎的临床治疗效果。方法 选取2020年6月—2022年5月在周口市中医院就诊的82例毛细支气管炎患儿,按照随机数字表法将所有患儿分为对照组和治疗组,每组各41例。对照组雾化吸入吸入用布地奈德混悬液,0.5 mg/次,2次/d。治疗组在对照组基础上口服小儿麻甘颗粒,1岁以下：0.8 g/次,1～3岁：1.6 g/次,4岁及以上：2.5 g/次,4次/d。两组连续治疗7 d。观察两组的临床疗效,比较两组的主要症状消失时间、肺通气功能和血清指标的水平。结果 治疗后,治疗组的总有效率为95.12%,明显高于对照组的总有效率80.49%,组间比较差异具有显著性（P<0.05）。治疗后,治疗组咳嗽、哮鸣音、气喘、肺部阴影消失时间均明显短于对照组,差异有统计学意义（P<0.05）。治疗后,两组的呼吸频率（RR）显著降低,呼气峰流速值（PEF）、吸呼比（tI/tE）显著升高（P<0.05）;治疗组的RR低于对照组,PEF、tI/tE高于对照组（P<0.05）。治疗后,两组的血清白细胞介素-4(IL-4)、转化生长因...     

小儿热速清糖浆联合对乙酰氨基酚治疗儿童发热的多中心随机双盲双模拟的比较研究

目的 分析小儿热速清糖浆联合对乙酰氨基酚治疗儿童发热的多中心随机双盲双模拟的比较研究。方法 采用多中心随机双盲双模拟的对比试验方法,病例来源于2021年4月—2023年4月牡丹江市第一人民医院、滕州市妇幼保健院、牡丹江妇幼保健院门诊或住院部就诊及招募的外感发热患儿240例,利用SAS统计软件按区组随机化法分为对照1组（80例）、对照2组（80例）、治疗组（80例）。对照1组口服对乙酰氨基酚混悬液,1～3岁,体质量12～15 kg,3 mL/次;4～6岁,体质量16～21 kg,5 mL/次;7～9岁,体质量22～27 kg,8 mL/次;10～12岁,体质量28～32 kg,10 mL/次。若持续发热或疼痛,每隔4～6 h重复用药1次,24 h不可超过4次。同时服用小儿热速清糖浆模拟剂,服用方法同对照2组。对照2组口服小儿热速清糖浆,1～3岁,5～10 mL/次;4～6岁：10～15 mL/次;7～12岁,15～20 mL/次;3～4次/d。同时口服对乙酰氨基酚混悬液模拟剂,其方法同对照1组。治疗组口服对乙酰氨基酚混悬液联合小儿热速清糖浆,服用方法与对照1组、对照2组相同。1个疗程72...     

Monodispersed redox submicrometer particles created by polyaniline-coated polystyrene latex

A spherical electroactive particle, 65 nm in diameter, was synthesized by coating a sulfonated polystyrene latex particle with the electric conducting polymer (polyaniline). It was suspended in acidic solution, and hence its electrochemical properties were obtained by the usual electrochemical techniques. The following behavior is predicted: when the particle comes into contact with the electrode by diffusion, the polyaniline layer takes the same potential as the electrode owing to the electric conduction; consequently, the whole polyaniline layer reacts at the electrode simultaneously as if the number of electrons transferred was very large. The anodic voltammetric peak, due to the oxidation of the radical cation to the dication, was controlled by diffusion of the particle. The diffusion coefficient obtained by the limiting current was half the value evaluated from the Stokes–Einstein relation. The steady-state voltammogram at a microelectrode and a rotating disk electrode showed a ?0.2 V potential shift from the surface waves of the electrochemically synthesized polyaniline film, probably due to stabilization of the radical cation in the colloidal form. The number of the charge relevant to the electrode reaction was n=4.2×10⁵, determined not only by the bulk electrolysis, but also by the analysis of chronoamperometric curves. The overall process is diffusion of the particle composed of n redox sites, followed by n parallel sluggish charge-transfer reactions.     

中西医结合治疗腹泻型肠易激综合征30例

[目的]观察五苓散合痛泻药方加减联合硫糖铝混悬液治疗腹泻型肠易激综合征(IBS)的临床疗效。[方法]将60例IBS患者随机分为两组。治疗组30例,以五苓散合痛泻药方加减联合硫糖铝混悬液治疗;对照组30例,用西药常规治疗;[结果]治疗组和对照组显效率和总有效率比较(P<0.05)有统计学意义。[结论]五苓散合痛泻药方加减联合硫糖铝混悬液治疗腹泻型肠易激综合征临床疗效显著。     

Particle growth in aqueous suspensions: the influence of surface energy and polarity

The aggregation of drug particles in suspensions can cause products to be spoiled. In this paper the role of surface energetics in controlling the dispersion of powders in water is considered, by use of a spreading coefficient. The contact angles, surface energies and the polarities were determined for a series of barbiturate powders. Contact angles were measured using a Wilhelmy plate technique. Aqueous suspensions of each powder were prepared and the change in particle size was monitored over a period of hours and days. By extrapolation the limiting size of the aggregates was calculated and this was related to the original particle size of each powder. The powders were largely hydrophobic in nature, and as such were difficult to disperse in the liquid. It was determined that dispersion was possible only if the negative spreading coefficient of water over the powder did not have a significantly larger value than the dispersion component of the water. This has been explained in terms of the hydrophobic powder tending to interact with the dispersive, rather than the polar, entities in the water. For powders which spontaneously dispersed in the water a good correlation existed between the increase in particle size noted in the suspension and the spreading coefficient.     

High yield formation of o -aminobenzoic acid-7- O -β- d -(β-1,6- O - d -glucopyranosyl)-glucopyranosyl ester in cell suspension cultures of Solanum mammosum

Cell suspension cultures of Solanum mammosum cultivated in modified Murashige & Skoog media could synthesize o -aminobenzoic acid-7- O - β- d -( β-1,6- O - d -glucopyranosyl)-glucopyranosyl ester from o -amino benzoic acid with a yield of about 20% dry weight in 7 days. The maximum production of o -aminobenzoic acid-7- O - β- d -( β-1,6- O - d -glucopyranosyl)-glucopyranosyl ester was 31.8% on dry weight basis.     

基于悬浮芯片技术的56种病原微生物的高通量检测

目的:建立高通量、快速、可靠、经济的病原微生物诊断技术平台。方法:设计和合成针对56种常见病原微生物的探针和阳性对照,采用悬浮芯片技术,对56种病原微生物的阳性标准品进行检测。结果:56种标准品的检测值显著高于阴性对照,各病原微生物的阳性标准品和各探针之间无交叉反应。结论:建立了高通量、快速、可靠、经济的病原微生物诊断技术平台,为突发传染病的病原体诊断提供技术储备。     

HPLC法测定利福昔明干混悬剂中利福昔明的含量

目的：建立高效液相色谱法测定利福昔明干混悬剂中利福昔明的含量限度的方法。方法：采用高效液相色谱法，色谱柱为Kromasil C8，甲醇-乙腈-0．075mol／L磷酸二氢钾溶液-1．0mol／L枸橼酸溶液（50：22．5：22．5：5）为流动相，流速为1．0ml／min，检测波长为240nm。结果：利福昔明在41．02～164．08μg／ml范围内线性关系良好（r=0．99997），平均回收率为99．79％，RSD为1．30％，规定含量限度为90．0％～110．0％。结论：本法准确、灵敏、可靠，能有效地控制该制剂的质量。     

头孢克洛颗粒及干混悬剂溶出度的研究

目的研究测定头孢克洛颗粒以及干混悬剂溶出度的方法。方法采用浆法,以水为溶出介质,转速为50r/min,紫外-可见分光光度法264nm波长处测定吸光度。结果头孢克洛颗粒和干混悬剂在5min的溶出量均不少于80%。结论方法准确可靠,能满足质量控制要求。