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Daniel Herwartz Andreas Pack Thorsten J. Nagel 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(23)
The low 18O/16O stable isotope ratios (δ18O) of ancient chemical sediments imply ∼70 °C Archean oceans if the oxygen isotopic composition of seawater (sw) was similar to modern values. Models suggesting lower δ18Osw of Archean seawater due to intense continental weathering and/or low degrees of hydrothermal alteration are inconsistent with the triple oxygen isotope composition (Δ’17O) of Precambrian cherts. We show that high CO2 sequestration fluxes into the oceanic crust, associated with extensive silicification, lowered the δ18Osw of seawater on the early Earth without affecting the Δ’17O. Hence, the controversial long-term trend of increasing δ18O in chemical sediments over Earth’s history partly reflects increasing δ18Osw due to decreasing atmospheric pCO2. We suggest that δ18Osw increased from about −5‰ at 3.2 Ga to a new steady-state value close to −2‰ at 2.6 Ga, coinciding with a profound drop in pCO2 that has been suggested for this time interval. Using the moderately low δ18Osw values, a warm but not hot climate can be inferred from the δ18O of the most pristine chemical sediments. Our results are most consistent with a model in which the “faint young Sun” was efficiently counterbalanced by a high-pCO2 greenhouse atmosphere before 3 Ga.The amount of carbon that degassed from a solidifying magma ocean on the infant Earth 4.5 Ga ago was probably similar to the amount of CO2 that is now present in the atmosphere of Venus (pCO2 ∼90 bar) (1). Subsequently, dynamic carbon cycling between the early Earth’s atmosphere (atmospheric reservoir [RA]), the ocean (RO), and the oceanic crust (ROC) reservoirs stabilized a primordial Earth–atmospheric pCO2 to about 1.5 bar (2). Decreasing pCO2 over the Earth’s history reflects the net transfer of large masses of carbon out of the atmosphere-ocean-oceanic crust (RA+O+OC) system into the mantle and the emerging continental crust reservoir (RCC), the latter providing a long-term sink for carbon in the form of inorganic carbon (carbonate rocks) and organic material (organic matter–rich shales, coal, oil, and gas) (1, 2).Early carbon-cycle models predicted high Archean pCO2 to account for the faint young Sun paradox (2, 3), whereas direct pCO2 estimates from the end of the Archean now imply much lower atmospheric pCO2 [∼0.01 to 0.1 bar (4)]. However, a compilation of evidence from the sedimentary record implies much higher pCO2 between 3.2 to 3.0 Ga compared to the 2.9 to 2.7 Ga interval (5). These authors state that even several bars pCO2 are feasible between 3.2 to 3.0 Ga, which is not in conflict with much lower Neoarchean pCO2 estimates (Fig. 1) or paleo-atmospheric pressure estimates at 2.7 Ga [<2 bar (6) and <0.5 bar (7)]. A fundamental drop in atmospheric CO2 mixing ratio is also reflected in the observation that >3 Ga, Archean mafic crust (greenstones) is commonly characterized by very intense carbonatization and silicification that is unparalleled in their modern analogs (8–12). Such observations provide evidence for deep-time paleo-pCO2 fluctuations with a drastic pCO2 drop starting around 3 Ga ago (5, 13).Open in a separate windowFig. 1.Constraints on the RA+O+OC size over time with implications for pCO2. A illustrates the size of the RA+O+OC carbon reservoir and its distribution between the oceanic crust (ROC in gray), ocean water (RO in dark blue), and the atmosphere (RA in light blue). Transition of this carbon to the long-term RCC and the mantle (green) decreases the size of the RA+O+OC reservoir, which was still large at 3.2 Ga (see SI Appendix) and minimal at the onset of the global glaciations at 2.4 Ga. B shows two recent pH curves over Earth’s history to illustrate how the pH-dependent distribution of carbon between RA and RO may translate into pCO2 at a given time. (C) The panel summarizes pCO2 estimates [adopted from Catling and Zahnle (4)] and proposed pCO2 evolution curves illustrated as dashed lines: a (2), b (18), and c (proposed here). Qualitative evidence to construct curve c comes from rare evidence for glaciers (44) and lower degrees of carbonatization of oceanic crust at 3.5 Ga compared to 3.2 Ga (13), suggesting a transient interval of somewhat low pCO2 in the Paleoarchean. Low pCO2 is indicated prior to the onset of cold climates later in the rock record. The black bar at 4.5 Ga is derived from carbon-flux arguments and the primordial carbon reservoir (1, 2). The black bar at 3.2 Ga applies the same carbon-flux arguments to translate the high carbonate content observed in the oceanic crust in Pilbara into tentative pCO2 estimates (SI Appendix), which are most consistent with curve a (2).Today, carbonatization, which is the formation of carbonates during alteration of the oceanic crust, mainly occurs in relatively cool, off-axis hydrothermal systems over the first 20 Mya after crust formation at midocean ridges (14–16). Elevated degrees of carbonatization in oceanic crust from the Cretaceous and Jurassic are assigned to higher dissolved inorganic carbon at the time (14). Hence, higher pCO2 (i.e., a larger RA+O+OC) directly translates into higher degrees of carbonatization. While carbonate is mainly observed as vein fillings in the upper 300 m of oceanic crust today (14, 15), it extensively replaces glass and igneous minerals in Archean greenstones down to depths of 2 km below the ancient seafloor (8–10, 17). The amount of CO2 fixed in 3.2-Ga-old oceanic crust from Pilbara, Australia is estimated at 1.2 × 107 mol ⋅ m−2 (±10%) (17)—a remarkable figure that is about two orders of magnitude more compared to today (SI Appendix). Much lower degrees of carbonatization in oceanic crust are already observed at 2.6 Ga, suggesting a drastic Mesoarchean drop in pCO2 (13) (Fig. 1A).The qualitative evidence from the sediment record (5) and from the degree of carbonatization and silicification of oceanic crust (13) has not been included in proposed pCO2 curves (4, 18) because the quantitative conversions into absolute pCO2 require some assumptions (SI Appendix). Nevertheless, pCO2 during the early Archean may have been as high as initially predicted by Kasting (2), followed by a pronounced Mesoarchean drop (13) to levels consistent with available paleo-pCO2 estimates toward the Neoarchean (4) (stippled line “c” in Fig. 1C). Further decreasing pCO2 toward modern levels partly reflects increasing ocean pH (Fig. 1) rather than a shrinking RA+O+OC (SI Appendix). Hence, only small effects of carbonatization on the δ18Osw value are expected for post-Archean seawater (16). Here, we focus on the very high carbonatization (8–10, 13) and silicification (11, 12) fluxes before the Mesoarchean pCO2 drop, and we model the respective effects on ancient δ18Osw. 相似文献
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Summary Defence against oxidative damage by UV-generated free radicals in both guinea pig and human skin has been found to be mediated by the ubiquitous thioprotein, thioredoxin reductase. Human keratinocytes contain approximately 5% thioredoxin reductase in their total acidic protein fraction and also express membrane-associated enzyme activity in cells cultured in synthetic medium. The thioredoxin reductase/thioredoxin system has been shown to reduce superoxide anion radicals through hydrogen peroxide to water. However, both UVA and UVB radiation, below the minimal erythemal dose, generate a sufficiently high concentration of oxygen radicals to deactivate thioredoxin reductase considerably. In albino guinea pigs, enzyme deactivation was up to 70% for UVA and 66% for UVB (n=10 animals/protocol). The application of sun blockers SPF4, SPF8 and SPF15 to albino guinea pig skin offered no significant protection for the deactivation of thioredoxin reductase by either UVA or UVB radiation. In the human population (n=15), thioredoxin reductase was deactivated by 54% with UVA and 36% with UVB radiation, although the degree of enzyme inhibition depended on skin phototype (I–VI, Fitzpatrick Classification). SPF24 offered considerable protection for thioredoxin reductase against both UVA and UVB for skin types I and II. However, SPF24 yielded no significant protection with UVA for skin types III–VI, and enhanced the enzyme inhibition with UVB additively. These results indicate that UVB photo-oxidation of oxybenzone (the UVA filter in SPF24) may deactivate thioredoxin reductase in more pigmented members of the population by Michael addition of oxybenzone semiquinone to the thiolate active site of this enzyme. 相似文献
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孙思邈,自号孙真人,唐初著名医学家,总结唐以前临床经验和医学理论,著《备急千金要方》及《千金翼方》二书。孙氏学识渊博,品德高尚,其学术思想是多方面的,如重视医德与医术相结合,将医为仁术的精神具体化;重视对药学和方剂学的研究,被后世誉为药王;研究伤寒的观点和方法对后世启发颇多;提倡食治与养性、养老等。此外,孙思邈在针灸学研究方面亦十分突出,他保存了唐以前重要的针灸文献史料,并首绘彩色《明堂经图》;明确指寸取穴法,勘定穴位,发展经穴理论;完善针灸治疗大法,重视针灸预防与治疗作用;临证重视诊脉刺灸,治疗疾病针、灸、药并重,对后世针灸学的发展具有重要贡献,今以《备急千金要方》及《千金翼方》二书中的针灸内容为据,探讨孙思邈在针灸学方面的主要学术贡献。 相似文献
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M.?Shyam?Kumar P.?K.?Datta S.?Dutta GuptaEmail author 《Journal of natural medicines》2009,63(2):195-199
In this study, lyophilized crude and methanolic extracts of aloe gel from different germplasms (S24, RM, TN, OR, and RJN)
of Aloe vera L. were tested for their ultraviolet (UV) opacity potential. UV absorption profiles, sun protection factor (SPF), and percentage
blocking of UVA and UVB were considered to test UV opacity potential. Both the extracts showed UV absorption and followed
the same path in the wavelength range of 250–400 nm in all the germplasms. Methanolic extract showed a stronger absorptivity
than the crude lyophilized extract. Among the tested germplasms, maximum UV opacity property with a SPF of 9.97% and 79.12%
UVB blocking was obtained with RJN, whereas a poor response was evident in TN with a SPF of 1.37% and 28.5% UVB blocking at
4 mg/ml methanolic extract. To our knowledge the present work for the first time documents UV opacity properties of A. vera L. gel and opens up new vistas in Aloe gel characterization. 相似文献