双黄连口服液与雷尼替丁用于口腔溃疡治疗的临床疗效观察

目的口腔溃疡以双黄连口服液及雷尼替丁治疗的效果。方法将84例口腔溃疡患者随机分为研究组与对照组,对照组雷尼替丁治疗,研究组联合双黄连口服液治疗,对比疗效。结果研究组疗效优于对照组(P<0.05)。结论口腔溃疡以双黄连口服液及雷尼替丁治疗效果理想。     

Elf-1在胃癌组织中的表达及其临床意义

目的 探讨转录因子Elf-1在胃癌组织中的表达及其与胃癌临床病理学特征的关系.方法 采用免疫组织化学染色的方法检测70例胃癌组织及相应的癌旁组织、远癌黏膜组织中Elf-1的表达,分析Elf-1表达与胃癌及其临床病理特征的关系.结果 Elf-1在胃癌、癌旁组织、远癌黏膜组织中表达的阳性率分别为88.6%、55.7%、5.0%,Elf-1在胃癌中的表达率明显高于癌旁组织及远癌黏膜组织,差异有显著性(Hc=70.11,P<0.01);Elf-1在胃癌中的表达与分化程度、浸润深度、临床分期及淋巴结转移有关(Hc=-4.81～19.62,P<0.01).结论 Elf-1与胃癌的发生及发展有关,检测Elf-1的表达水平对于胃癌早期诊断及预后评估具有重要参考价值.     

Infectious pathogens and risk of esophageal,gastric and duodenal cancers and ulcers in China: A case-cohort study

Infection by certain pathogens is associated with cancer development. We conducted a case-cohort study of ~2500 incident cases of esophageal, gastric and duodenal cancer, and gastric and duodenal ulcer and a randomly selected subcohort of ~2000 individuals within the China Kadoorie Biobank study of >0.5 million adults. We used a bead-based multiplex serology assay to measure antibodies against 19 pathogens (total 43 antigens) in baseline plasma samples. Associations between pathogens and antigen-specific antibodies with risks of site-specific cancers and ulcers were assessed using Cox regression fitted using the Prentice pseudo-partial likelihood. Seroprevalence varied for different pathogens, from 0.7% for Hepatitis C virus (HCV) to 99.8% for Epstein–Barr virus (EBV) in the subcohort. Compared to participants seronegative for the corresponding pathogen, Helicobacter pylori seropositivity was associated with a higher risk of non-cardia (adjusted hazard ratio [HR] 2.73 [95% CI: 2.09–3.58]) and cardia (1.67 [1.18–2.38]) gastric cancer and duodenal ulcer (2.71 [1.79–4.08]). HCV was associated with a higher risk of duodenal cancer (6.23 [1.52–25.62]) and Hepatitis B virus was associated with higher risk of duodenal ulcer (1.46 [1.04–2.05]). There were some associations of antibodies again some herpesviruses and human papillomaviruses with risks of gastrointestinal cancers and ulcers but these should be interpreted with caution. This first study of multiple pathogens with risk of gastrointestinal cancers and ulcers demonstrated that several pathogens are associated with risks of gastrointestinal cancers and ulcers. This will inform future investigations into the role of infection in the etiology of these diseases.     

腹腔镜下消化性溃疡急性穿孔修补术17例临床分析

目的 探讨腹腔镜下胃十二指肠溃疡穿孔修补术的可行性及操作要点.方法 十二指肠溃疡15例,胃窦部溃疡2例,采用腹腔镜探查证实为急性穿孔并作溃疡穿孔修补术.结果 腹腔镜下手术均获成功,无中转开腹,平均手术时间57.9 min,平均住院时间5.7 d,无手术并发症.结论 腹腔镜下消化性溃疡穿孔修补术创伤小,并发症少,具有集诊断与治疗于一体的优点,是切实可行的治疗消化性溃疡穿孔的手术方法.     

Nurse-led patient education for persons suffering from a venous leg ulcer in outpatient's clinics and homecare settings: A scoping review

Aim of this studyTo provide an overview of the available nurse-led individualized educational interventions, for persons with Venous Leg Ulcer (VLUs) in an outpatient or homecare settings.Materials and methodsFor this scoping review, a search was performed between December 2019 and January 2020. To identify sources of evidence a systematic search was conducted in PubMed, CINAHL, Embase, PsychINFO, Web of Science and LiSSa as well as in clinical trial registers to identify sources of evidence. All types of evidence associated with a nurse led-intervention were included.ResultsFifteen sources of evidence met the inclusion criteria. Educational sessions varied in modality, content and duration. Education sessions were face to face and supported by written materiel. The content focused on compression therapy and exercises. The duration and numbers of sessions varied. The most reported health related outcomes was wound healing.ConclusionThis scoping review provides a broad overview of the available evidence and ongoing research for individualized nurse-led education persons with VLUs. Variability in the literature was found, which suggests that more intervention studies are needed to test and evaluate efficacy of nurse-led patient education.     

石辛含片治疗复发性口疮(胃火上炎证)的随机双盲安慰剂对照多中心临床试验研究

目的:评价石辛含片治疗复发性口疮(胃火上炎证)的有效性与安全性.方法:采用优效性检验、进行随机双盲单模拟、安慰剂平行对照、多中心临床试验设计.试验组和对照组分别给予石辛含片和安慰剂,疗程为5 d.主要疗效评价指标为疼痛初始缓解时间,次要疗效评价指标为全部溃疡愈合率、目标溃疡愈合率、目标溃疡存在时间、溃疡总数、疼痛指数、...     

咽喉反流性疾病的影响因素及治疗效果分析

了解咽喉反流性疾病(LPRD)的影响因素和治疗效果。     

Association between the Dietary Inflammatory Index and Gastric Disease Risk: Findings from a Korean Population-Based Cohort Study

Evidence suggests that diets with high pro-inflammatory potential may play a substantial role in the origin of gastric inflammation. This study aimed to examine the association between the energy-adjusted dietary inflammatory index (E-DII^TM) and gastric diseases at baseline and after a mean follow-up of 7.4 years in a Korean population. A total of 144,196 participants from the Korean Genome and Epidemiology Study_Health Examination (KoGES_HEXA) cohort were included. E-DII scores were computed using a validated semi-quantitative food frequency questionnaire. Multivariate logistic regression and Cox proportional hazards regression were used to assess the association between the E-DII and gastric disease risk. In the prospective analysis, the risk of developing gastric disease was significantly increased among individuals in the highest quartile of E-DII compared to those in the lowest quartile (HR_quartile4vs1 = 1.22; 95% CI = 1.08–1.38). Prospective analysis also showed an increased risk in the incidence of gastritis (HR_quartile4vs1 = 1.19; 95% CI = 1.04–1.37), gastric ulcers (HR_quartile4vs1 = 1.47; 95% CI = 1.16–1.85), and gastric and duodenal ulcers (HR_quartile4vs1 = 1.46; 95% CI = 1.17–1.81) in the highest E-DII quartile compared to the lowest quartile. In the cross-sectional analysis, the E-DII score was not associated with the risk of gastric disease. Our results suggest that a pro-inflammatory diet, indicated by high E-DII scores, is prospectively associated with an increased risk of gastric diseases. These results highlight the significance of an anti-inflammatory diet in lowering the risk of gastric disease risk in the general population.     

胃溃疡患者的循证护理要点及护理效果评价

目的探讨胃溃疡患者实施循证护理的要点及护理效果。方法2017年1月-2018年12月对消化内科80例胃溃疡患者实施研究,按随机数表法分组:常规组(n=40)和循证组(n=40),对常规组患者实施常规护理,对循证组进行循证护理,分析护理过程对患者认知状况、生活质量、依从性、病情恢复状况的影响。结果循证组护理后认知评分、生活质量评分与常规组组间对比更高(P<0.05)。循证组依从性高于常规组(P<0.05)。循证组病情恢复优良率高于常规组(P<0.05)。结论对胃溃疡患者实施循证护理可改善患者认知及依从性,提升患者康复效果及生存质量。