The Relationship Between Cortical Excitability and Pain Catastrophizing in Myofascial Pain

Pain catastrophizing regularly occurs in chronic pain patients. It has been suggested that pain catastrophizing is a stable, person-based construct. These findings highlight the importance of investigating catastrophizing in conceptualizing specific approaches for pain management. One important area of investigation is the mechanism underlying pain catastrophizing. Therefore, this study explored the relationship between a neurophysiological marker of cortical excitability, as assessed by transcranial magnetic stimulation, and catastrophizing, as assessed by the Brazilian Portuguese Pain Catastrophizing Scale, in patients with chronic myofascial pain syndrome. The Pain Catastrophizing Scale is a robust questionnaire used to examine rumination, magnification and helplessness that are associated with the experience of pain. We include 24 women with myofascial pain syndrome. The Brazilian Portuguese Pain Catastrophizing Scale and cortical excitability were assessed. Functional and behavioral aspects of pain were evaluated with a version of the Profile of Chronic Pain scale and by multiple pain measurements (eg, pain intensity, pressure pain threshold, and other quantitative sensory measurements). Intracortical facilitation was found to be significantly associated with pain catastrophizing (β = .63, P = .001). Our results did not suggest that these findings were influenced by other factors, such as age or medication use. Furthermore, short intracortical inhibition showed a significant association with pressure pain threshold (β = .44, P = .04). This study elaborates on previous findings indicating a relationship between cortical excitability and catastrophizing. The present findings suggest that glutamatergic activity may be associated with mechanisms underlying pain catastrophizing; thus, the results highlight the need to further investigate the neurophysiological mechanisms associated with pain and catastrophizing.     

血清标记物联合检测对急性冠脉综合征短期预后的临床意义

目的　探讨血清标记物联合检测对急性冠脉综合征(ACS) 患者短期预后的临床意义。方法　选取120例非ST段抬高的ACS患者作为观察对象, 均测定入院时肌钙蛋白I(cTnI)、D-二聚体(D-Dimer) 和C-反应蛋白(CRP), 行常规治疗并记录30d内急性心脏事件(死亡、急性心肌梗死、顽固性心绞痛) 的发生情况。将三种血清标记物升高的患者称为A组, 任意两种血清标记物升高的患者称为B组, 仅cTnI单项升高的患者称为C组, 分别比较各组急性心脏事件的发生情况。结果　30d内共有34例患者发生急性心脏事件, 其中A组共6例(75. 00% ); B组共10例(55 .56% ); C组18例(56 .25% ), 急性心脏事件发生率间差异有显著性意义(χ2 =9 52, P<0. 05)。结论　应用血清标记物联合检测, 对ACS患者进行短期预后评价是较优越的方法。     

Reactivity to different saccharin concentrations as a function of testing procedure and alterations in body weight of intact and oophorectomized female rats

Two studies compared saccharin preference in oophorectomized and intact rats. Using a one bottle test, reliable preference difference between surgical groups were found at 0.1%, 0.4% and 0.75% saccharin concentrations. Using a two bottle test, reliable preference differences were found at the 0.4% and 0.75% concentrations. Although several differences were weight related, neither Marks' nor Zucker's hypotheses were supported.     

尿微量清蛋白检测在糖尿病肾病早期诊断中的临床应用

目的:研究尿微量清蛋白检测在糖尿病肾病早期诊断中的临床应用。方法:选取确诊的2型糖尿病患者160例,将80例诊断为糖尿病肾病的患者选作DM肾病组,将80例诊断早期2型糖尿病患者选作DM早期组,再选取相同时间内参加健康检查结果健康的80例选为健康组,对三组患者进行血液、24 h尿液检查,对比所有人的血葡萄糖(Glu)、血尿素(Un)、肌酐(Cr)及尿微量清蛋白(mAlb)的结果。结果:DM早期患者及DM肾病组患者的血葡萄糖、血尿素、肌酐及尿微量清蛋白结果明显高于健康组患者,而DM肾病组患者的血葡萄糖、血尿素、肌酐及尿微量清蛋白结果又明显的高于DM早期组患者,其中以尿微量清蛋白最为突出。结论:尿微量清蛋白检测对肾病有着较高的敏感度,可以积极的应用于临床帮助早期诊断糖尿病肾病。     

义齿固位力测试方法的改进研究

目的 针对现有固位力测试仪的不足,开发一套可操控性强,准确性良好的新型修复体固位力口内测试系统,并应用于临床,对其适用性和准确性加以验证.方法 应用新研制固位力测试系统,以20例下颌总义齿修复患者为测试对象,采用不同角度连续测量下颌总义齿固位力,对数据进行配对t检验(α=0.05).结果 相同受试者、相同施力方向义齿固位力差异无显著性(P＞0.05).相同受试者,不同施力角度,测量结果差异具有显著性(P＜0.05).结论 新型修复体固位力测试仪在临床上可有效地对义齿固位力进行多角度测量.     

Therapeutic trials and muscular diseases

Recent advances in knowledge of muscle diseases has opened new perspectives for clinical trials. Because of the small number of patients available for study and the requirement for homogeneous study groups, multicentric trials must be conducted on a national or international basis. Moreover, because of the variability of clinical course of muscle diseases therapeutic protocols must be preceded by an assessment of the natural history of the disease. Analytic methods available include manual testing, quantitative muscle testing (QMT), functional scales, and evaluation of cardiac and respiratory function. Based on experience acquired with earlier protocols, we present methodologies currently used and the difficulties encountered. We discuss the potential ways for improving therapeutic trials.     

2010至2012年某市艾滋病自愿咨询检测情况的分析

目的通过对2010至2012年许昌市艾滋病自愿咨询检测(Voluntary counseling and testing,VCT)资料进行分析,为指导VCT门诊工作开展提供科学依据。方法下载2010至2012年许昌市疾控中心VCT门诊上报数据,建立数据库,进行统计分析。结果 2010年至2012年共995人接受咨询检测服务,其中男性921人,求询者年龄以20到39岁的青壮年为主,占80.2%。求寻类型以男男性行为人群(men who have sex with men,MSM)为主,其次是非婚异性性行为人群。求询者HIV与梅毒抗体阳性检出率分别为5.94%与11.29%,其中MSM HIV与梅毒抗体阳性检出率均较高。文化程度越低HIV与梅毒抗体阳性检出率越高。结论做好VCT工作能及早发现感染者,及时开始治疗,提高患者生活质量,有效减少艾滋病的传播。     

A Tiered Approach to Life Stages Testing for Agricultural Chemical Safety Assessment

Aproposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the safety of crop protection chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoints and exposure durations that are relevant for risk assessment. The ACSA Life Stages Task Force proposes a tiered approach to toxicity testing that assesses a compound's potential to cause adverse effects on reproduction, and that assesses the nature and severity of effects during development and adolescence, with consideration of the sensitivity of the elderly. While incorporating many features from current guideline studies, the proposed approach includes a novel rat reproduction and developmental study with enhanced endpoints and a rabbit development study. All available data, including toxicokinetics, ADMEdata, and systemic toxicity information, are considered in the design and interpretation of studies. Compared to existing testing strategies, the proposed approach uses fewer animals, provides information on the young animal, and includes an estimation of human exposure potential for making decisions about the extent of testing required.     

情境合作考试在护理专业本科生基础护理操作考核中的应用

目的探讨情境合作考试在护理专业本科生基础护理操作考核中的应用。方法选取某校2010级243名护理专业本科生作为研究对象,实行情境合作考试模式。结束后评价该考试的难度、信度和效度,并用自设问卷调查学生对情境合作考试的评价。结果情境合作考试难度系数为0.775,Cronbach＇sα系数为0.749,与操作考试平时成绩和理论考试成绩的相关系数分别为0.646和0.479（P〈0.01）。78.2%的学生认为情境合作考试优于传统的基础护理操作考试。结论情境合作考试应用于基础护理操作考核具有科学性和可行性。