Efficacy and safety of acupuncture combined with Chinese herbal medicine in the treatment of type 2 diabetes mellitus: A protocol for a systematic review and meta-analysis

Background:Diabetes has become a global public health problem and danger to human health. Diabetes is the main cause of blindness, kidney failure, heart attack, stroke, and lower limb amputation. According to the latest epidemiological survey and research, the overall prevalence of diabetes in mainland China is 11.2%, of which type 2 diabetes mellitus (T2DM) accounts for more than 90% acupuncture combined with Chinese herbal medicine have been widely used in the treatment of T2DM. However, we have not found a meta-analysis of their synergistic effects. Therefore, this systematic review and meta-analysis aims to evaluate the efficacy and safety of acupuncture combined with Chinese herbal medicine in the treatment of T2DM.Method:From inception up to September 20, 2021, the PubMed, Web of Science, Embase, AMED, Cochrane Library, CNKI, VIP, CBM, and Wanfang databases will be searched. The publication date or language will not be limited. We will apply a combination of medical keywords, including “acupuncture”, “Chinese herbal medicine”, and “type 2 diabetes mellitus”. We will also check other ongoing and unpublished studies in the clinical trial registry. At the same time, we will manually search all reference lists from relevant systematic reviews to find other eligible studies. We will use Review Manager software (REVMAN v5.3 Cochrane Collaboration) to meta-analyze the selected literature. The study for acupuncture combined with Chinese herbal medicine in the treatment of T2DM was a randomized controlled study. Two researchers will independently review the research selection, data extraction, and research quality assessments. Finally, we will observe the outcome measures.Results:This study will generate evidence-based data on the treatment of T2DM with acupuncture combined with Chinese herbal medicine and will provide new ideas and treatment modalities to investigate in future research.     

咳喘平与病毒唑联合应用体外对呼吸道合胞病毒抑制作用的研究

目的了解咳喘平、病毒唑及二者联合应用时对呼吸道合胞病毒(RSV)的体外抑制作用。方法观察不同药物浓度下RSV对Hep-2细胞的致病作用。结果病毒唑完全抑制RSV复制的最小浓度为7·8μg/ml,咳喘平为13·75mg/ml,两药联合应用时,病毒唑和咳喘平完全抑制RSV的最小浓度分别减少到1·95μg/ml和3·44mg/ml,比单独用药浓度降低了4倍。结论两种药物对RSV都有体外抑制作用,联合应用时效果最强。     

The Changes in Endogenous Metabolites in Hyperlipidemic Rats Treated with Herbal Mixture Containing Lemon,Apple Cider,Garlic, Ginger,and Honey

An herbal mixture composed of lemon, apple cider, garlic, ginger and honey as a polyphenol-rich mixture (PRM) has been reported to contain hypolipidemic activity on human subjects and hyperlipidemic rats. However, the therapeutic effects of PRM on metabolites are not clearly understood. Therefore, this study aimed to provide new information on the causal impact of PRM on the endogenous metabolites, pathways and serum biochemistry. Serum samples of hyperlipidemic rats treated with PRM were subjected to biochemistry (lipid and liver profile) and hydroxymethylglutaryl-CoA enzyme reductase (HMG-CoA reductase) analyses. In contrast, the urine samples were subjected to urine metabolomics using ¹H NMR. The serum biochemistry revealed that PRM at 500 mg/kg (PRM-H) managed to lower the total cholesterol level and low-density lipoprotein (LDL-C) (p < 0.05) and reduce the HMG-CoA reductase activity. The pathway analysis from urine metabolomics reveals that PRM-H altered 17 pathways, with the TCA cycle having the highest impact (0.26). Results also showed the relationship between the serum biochemistry of LDL-C and HMG-CoA reductase and urine metabolites (trimethylamine-N-oxide, dimethylglycine, allantoin and succinate). The study’s findings demonstrated the potential of PRM at 500 mg/kg as an anti-hyperlipidemic by altering the TCA cycle, inhibiting HMG-CoA reductase and lowering the LDL-C in high cholesterol rats.     

正交试验优化“柴胡-白芍”药对提取工艺的研究

目的:优选出柴胡-白芍药对的最佳提取工艺。方法:采用正交设计法,通过高效液相色谱法以柴胡皂苷a、d和芍药苷等苷类成分的含量为指标综合评价,优化提取工艺。结果:最佳提取工艺为加10倍量70%乙醇,提取2次,每次1.5 h。结论:优选的提取工艺稳定,可行。     

论滑寿对《内经》、《难经》研究的贡献

滑寿,字伯仁,一字伯休,晚号樱宁生。元末明初著名医家,著有《十四经发挥》、《诊家枢要》、《读素问钞》、《难经本义》等医学著作,为中医学的发展作出了巨大贡献。《十四经发挥》为针灸学著作,《诊家枢要》则是脉诊专著。《读素问钞》是分类整理、择要类编《素问》之作,开节要类编《素问》之先河。《难经本义》则考证《难经》条文出处,详加点校,求其本义,使《难经》医理彰显于世,成为注释《难经》的典范之作。本文通过对《读素问钞》和《难经本义》两书的分析探讨,论述了滑寿对《内经》、《难经》研究的贡献。     

中草药茶饮料饮品凉茶的功效及安全性研究评述

目的：探讨中草药茶饮料饮品凉茶的功效及安全性。方法：从具有较浓厚的岭南文化内涵的凉茶的发展状况、保健功能、药理作用、安全性及毒理研究等方面进行评述。结果：凉茶存在成分不确定、毒副作用尚不明确以及缺乏科学评价体系等问题。随着凉茶产品的逐渐增多和扩大,凉茶的功效如何、凉茶长期应用是不是有毒性亟需系统的实验或临床研究证实。结论：目前亟需进行对凉茶的功效、毒理评价及安全性进行深入研究。     

微型钢板内固定配合中药熏洗治疗掌指骨骨折76例

目的：观察微型钢板内固定配合中药熏洗治疗掌指骨骨折的临床疗效。方法：76例患者均采用微型钢板内固定配合中药熏洗。结果：经治疗后,按TAM标准评定功能：优56例,良7例,优良率82．9％。结论：微型钢板内固定配合中药熏洗治疗掌指骨骨折疗效较好。     

中药离子导入配合药物治疗小儿支气管肺炎疗效观察

目的观察中药离子导入配合药物治疗小儿支气管肺炎的疗效。方法将164例肺炎患者随机分为两组,治疗组在常规药物治疗基础上加电脑中频药物导入治疗,对照组采用常规药物治疗,进行疗效比较。结果治疗组总有效率明显优于对照组（P〈0.01）。结论中药离子导入配合药物治疗小儿支气管肺炎有显著疗效。     

择时定喘膏穴位贴敷治疗小儿咳喘疗效观察

目的观察择时定喘膏穴位贴敷治疗小儿咳喘的疗效。方法将120例住院患者随机分为四组,时间选择在三伏、冬至当日穴位贴药（A组）,时间选择在三伏穴位贴药（B组）,时间选择在冬至当日（C组）,不择时间（D组）。观察四组患者治疗前后的症状、体征,计算各组总显效率、有效率,并做统计学处理,比较其疗效。结果四组之间总有效率和显效率相互比较,依次为A组〉B组〉C组〉D组,其中A组、B组疗效最为明显。结论夏季三伏中药定喘膏穴位贴敷能有效地预防咳喘和减轻临床症状与体征。     

滋阴养血润肠通便法治疗老年骨折合并便秘34例

[目的]观察滋阴养血润肠通便法治疗老年骨折便秘疗效。[方法]治疗34例,采用滋阴养血润肠通便方药,5天为1个疗程,一般治疗3～5个疗程。[结果]治疗34例,痊愈10例,显效11例,有效9例,无效4例。[结论]滋阴养血润肠通便法具有明显优势。