枳术丸煎剂与枳术汤对大鼠P物质的影响

目的探讨枳术丸与枳术汤对正常大鼠血浆P物质(SP)及肠组织SP的影响。方法正常大鼠分5组,灌胃给药7 d后采集标本,放免检测血浆及肠组织SP含量。结果枳术丸与枳术汤均能升高大鼠血浆SP及肠组织SP含量,呈一定的量-效关系,但枳术丸与枳术汤二者无显著差异。结论升高血及胃肠组织SP含量是枳术丸与枳术汤促进胃肠运动作用的机制之一。     

护肝宁片、葡醛内酯片治疗药源性肝损伤

目的：评价护肝宁片与葡醛内酯片治疗药源性肝损伤的疗效。方法：将77例药源性肝损伤患者随机分成护肝宁组39例，葡醛内酯组38例，分别给予护肝宁片及葡醛酯片治疗8周，观察第4周末及第8周末ALT、GGT。结果：第4周末ALT、GGT两组恢复正常率比较，差异有统计学意义（P〈0.105），第八周末比较，差异无统计学意义（P〉0．05）。结论：护肝宁片、葡醛内酯片治疗药源性肝损害均有效，而护肝宁片起效更快、疗程更短，值得临床上推广应用。     

睿祺片对胎鼠大脑皮层神经元内钙离子水平的影响

目的:探讨睿祺片对胎鼠大脑皮层神经元内游离钙离子水平的影响。方法:取妊娠16-17d Wistar大鼠的胚胎大脑皮层,培养4-5d随机分为睿祺片组及空白对照组,应用激光共聚焦扫描显微镜测定胎鼠大脑皮层神经元原代培养在加入睿祺片水溶液后细胞内钙离子水平的变化。结果:睿祺片组可降低神经细胞内游离钙离子浓度,空白对照组无此变化。结论:睿祺片可降低神经细胞内游离钙离子浓度,这可能是其改善记忆的作用机制之一。     

白癜风浓缩丸和澳能乳膏治疗白癜风临床观察

目的 观察白癜风浓缩丸与澳能乳膏治疗白癜风的疗效.方法 治疗组服用白癜风浓缩丸和局部外用澳能乳膏治疗白癜风28例,并与对照组服用白癜风丸和局部外用澳能乳膏治疗白癜风26例作对照观察.结果 两组疗效比较,两组总有效率有显著性差异(P＜0.05),治疗组优于对照组.结论 白癜风浓缩丸与澳能乳膏合用,疗效好,副作用少,是治疗白癜风有效的方法.     

口服避孕药在无排卵患者辅助生育技术中应用的观察

目的 :观察无排卵患者在体外受精 胚胎移植周期中 ,应用口服避孕药 (OC)能否减少促性腺激素激动剂(GnRH a)起始的激动作用所引起的功能性卵巢囊肿。方法 :对 78例无排卵性不孕的患者 ,采用A组 (n =52 )口服避孕药和B组 (n=2 6)卵泡期长方案进行超促排卵。结果 :给药 2周后A组的E2 水平 1 4 3 .78± 68.8pmol/L显著低于B组2 4 0 .8± 1 31 .8pmol/L(P =0 .0 0 1 ) ;A组喷鼻时间为 4 87± 1 .33天 ,较B组 1 6 .85± 2 .65天明显短 (P =0 .0 0 0 ) ;囊肿发生率A组 0 ,显著低于B组 1 9 2 % (5/ 2 6) (P =0 .0 0 1 ) ;其余各项无显著性差异 (P >0 .0 5)。结论 :OC联合GnRH a和卵泡期长方案对于无排卵性不孕患者均能获得较好的促排卵效果 ,但前者比后者囊肿形成率低、喷鼻时间缩短。     

Maintenance of ovulation inhibition with the 75-microg desogestrel-only contraceptive pill (Cerazette) after scheduled 12-h delays in tablet intake

BACKGROUND: In contrast to traditional progestagen-only pills (POPs), the desogestrel-only pill Cerazette consistently inhibits ovulation. This study was performed to test the hypothesis that desogestrel alone will keep inhibiting ovulation even when pills are taken 12 h late, indicating that delays in tablet intake of up to 12 h do not jeopardize contraceptive efficacy. METHODS: Women aged between 19 and 40 years with confirmed ovulation were admitted to this open-label pharmacodynamic study. They were treated with Cerazette for 56 days with three tablets to be taken 12 h late, having been randomized to a regimen with scheduled late tablets on Days 39, 42 and 49 (Group A) or on Days 11, 14 and 21 (Group B). The occurrence of ovulation during treatment was determined by measuring progesterone serum levels every 2 days. RESULTS: One of the 103 treated subjects ovulated during treatment. The ovulation incidence thus amounts to 1.0% (two-sided 95% confidence interval 0.02-5.29%). There was no apparent relationship between these ovulations and scheduled late tablets. The minimum time to first posttreatment ovulation was 7 days, whereas it took 17.2 days on average from last tablet intake until ovulation. CONCLUSIONS: Ovulation inhibition with Cerazette is maintained after 12-h delays in tablet intake and return of ovulation takes at least 7 days. These properties distinguish Cerazette from all other POPs.     

Association between birth control pills and voice quality

OBJECTIVES/HYPOTHESIS: The objective was to extend our knowledge of the effect of birth control pills on voice quality in women based on various acoustic measures. STUDY DESIGN: A longitudinal comparative study of 14 healthy young women over a 36- to 45-day period. METHODS: Voices of seven women who used birth control pills and seven women who did not were recorded repeatedly approximately 20 times. Voice samples were analyzed acoustically, using an extended set of frequency perturbation parameters (jitter, relative average perturbation, pitch period perturbation quotient), amplitude perturbation parameters (shimmer, amplitude average perturbation quotient), and noise indices (noise-to-harmonics ratio, voice turbulence index). RESULTS: Voice quality and stability were found to be better among the women who used birth control pills. Lower values were found for all acoustic measures with the exception of voice turbulence index. Results also provided preliminary indication for vocal changes associated with the days preceding ovulation. CONCLUSION: In contrast to the traditional view of oral contraceptives as a risk factor for voice quality, and in keeping with the authors' previous work, the data in the present study showed that not only did oral contraceptives have no adverse effect on voice quality but, in effect, most acoustic measures showed improved voice quality among women who used the birth control pill. The differences in the noise indices between groups may also shed light on the nature of the effect of sex hormones on vocal fold activity. It was suggested that hormonal fluctuations may have more of an effect on vocal fold regulation of vibration than on glottal adduction.     

Ovulation and risk of epithelial ovarian cancer

Incessant ovulation is thought to be one of the primary causes of epithelial ovarian cancer. However, the effects of ovulation at different ages and of the various exposures or events that suppress ovulation have not been established. We used data from an Australian case-control study of 791 ovarian cancer cases and 853 controls to examine the effect of ovulation on ovarian cancer risk. The total number of lifetime ovulations was calculated using information provided in a monthly contraceptive/reproductive calendar, as well as incorporating other information such as average menstrual cycle length. An increase of 1 year's worth of ovulation was associated with a 6% increase in risk of ovarian cancer (95% confidence interval [CI] = 4-8%). Ovulations in the 20-29-year age group were associated with the greatest risk, with a 20% increase in risk associated with each year of ovulation during this age period (95% CI = 13-26%). When the effects of different exposures that suppress ovulation were compared, there was an indication that some factors may have a greater effect than others. These findings support the theory that incessant ovulation is a major contributor to the occurrence of ovarian cancer and suggest that ovulations during the 20s may be those most associated with disease risk.     

Weight gain on the combined pill--is it real?

Britain has one of the highest teenage pregnancy rates in Western Europe at 8.8 per 1000 live births. Adolescents are very preoccupied with body image and fear weight gain with use of the combined oral contraceptive (COC) pill. Compliance with contraception continues to be a major issue. Is there a real evidence of weight gain? Or are there discrepancies between adolescent perceptions of weight gain with COC use and available scientific evidence? We carried out a comprehensive literature search and did not find evidence for the purported weight gain with use of low dose COCs. Adolescents need reassurance by gynaecologists, general practitioners, family planning doctors and mass media to remove such misperceptions. This will contribute in some way to reduce the high unintended pregnancy rates.