不同麻醉和镇痛方法对胸科手术胰岛素抵抗及相关因素影响的研究

目的 研究不同麻醉和术后镇痛方式对胸科手术后胰岛素抵抗(insulin resistance,IR)的影响及相关因素.方法 60例胸科手术患者按随机数字表法随机分为两组:对照组(GA组,n=30),实验组(GEA组,n=30).GA组行全麻+术后静脉镇痛;GEA组行硬膜外麻醉复合全麻+术后硬膜外镇痛.分别于麻醉前、术毕...     

抵抗素与炎症、动脉粥样硬化研究进展

抵抗素最初被认为是联系肥胖与胰岛素抵抗、2型糖尿病的脂肪细胞因子。然而近年来研究发现其在人体主要与炎症有关,抵抗素不仅促进炎症的发生,而且炎症因子也可影响抵抗素的表达。动脉粥样硬化是一种慢性亚临床性炎症,大量的研究表明抵抗素与动脉粥样硬化相关。抵抗素通过局部和全身炎症作用诱导内皮功能失调、巨噬细胞的脂质沉积以及平滑肌增殖迁移,从而促进动脉粥样硬化的发生发展。     

血浆抵抗素与非酒精性脂肪肝胰岛素抵抗关系

目的:探讨非酒精性脂肪肝(NAFLD)血浆抵抗素水平与胰岛素抵抗的关系。方法:对福州总医院2007年6月至2008年4月32例NAFLD患者、29例脂肪肝并2型糖尿病患者和30例正常对照者,采用ELISA方法测定空腹血浆抵抗素,同时检测其身高、体重、腰围、臀围、血压、血糖、血脂、肝功能及胰岛素水平,并计算体重指数(BMI)、腰臀比(WHR)和胰岛素敏感指数(ISI)。结果:非酒精性脂肪肝组腰围、臀围、腰臀比、体重指数、空腹胰岛素(FINS)、丙氨酸氨基转移酶(ALT)、甘油三酯(TG)、低密度脂蛋白(LDL)、抵抗素水平均较正常对照组高,胰岛素敏感指数较对照组低,脂肪肝并2型糖尿病组胰岛素抵抗程度较非酒精性脂肪肝组更严重,抵抗素水平更高。相关分析显示血浆抵抗素与空腹胰岛素呈正相关(r=0.253,P=0.041),与胰岛素敏感指数呈负相关(r=-0.313,P=0.037),而与体重指数、腰臀比、血压、血脂、血糖无相关性。结论:非酒精性脂肪肝存在不同程度胰岛素抵抗,抵抗素水平升高;合并2型糖尿病者胰岛素抵抗更为严重,抵抗素水平更高。     

ST段抬高性急性心肌梗死患者血浆抵抗素浓度的变化

目的揭示ST段抬高性急性心肌梗死（STEAMI）患者血浆抵抗素浓度的变化,探讨其临床意义。方法收集STEAMI患者107例作为观察组、健康体检者40例作为对照组。对照组静脉血体检时获得。STEAMI患者静脉血在入院时、入院后第1、3、5、7和10天获得。ELISA法测定血浆抵抗素浓度。结果STEAMI患者住院期间主要不良心脏事件（MACE）发生29例（27．1％）。STEAMI后血浆抵抗素浓度显著升高。在各个时间点,MACE组血浆抵抗素浓度均显著高于非MACE组（P〈0．05）。ROC曲线显示血浆抵抗素浓度预测MACE有显著意义（曲线下面积=0．776,95％CI=0．721-0．846,P=-0．000）,判定入院时血浆抵抗素浓度23．7ng/mL,对预测MACE有69．0％的灵敏度和65．3％的特异度。结论STEAMI后血浆抵抗素浓度显著升高,有助于早期判断STEAMI患者住院期间MACE的发生。     

贝那普利对急性脑梗死患者血清抵抗素水平的影响

目的观察贝那普利对临床急性脑梗死（ACI）病人血清抵抗素水平的影响及意义。方法选取临床ACI病人62例,随机分为常规治疗组（32例）和贝那普利治疗组（30例）,并以25例非脑血管病患者作为对照组。两组ACI病人均给予常规药物治疗2周;治疗组在常规治疗的基础上加用贝那普利10mg,每日1次口服,治疗2周。所有研究对象均测定治疗前后的血压、高敏C-反应蛋白（hs—CRP）和抵抗素,并评定神经功能缺损程度（NDS）评分。结果两组ACI患者血清hs—CRP和抵抗素水平均较对照组显著升高（P〈0．01）,血清抵抗素水平与NDS呈正相关（r=0．38,P〈0．01）。ACI常规治疗组和贝那普利治疗组病人治疗后的hs—CRP和抵抗素水平均明显降低（P〈0．05）,但是贝那普利治疗组治疗前后的差值更为显著（P〈0．05）;ACI常规治疗组和贝那普利治疗组治疗后的NDS均较治疗前下降,但是贝那普利治疗组NDS的下降更为明显（P〈0．05）。结论贝那普利能降低ACI病人的抵抗素水平,减少病人的炎症反应,并有助于促进病人彳中经功能恢复。     

2型糖尿病合并冠心病患者抵抗素测定及其意义

目的研究抵抗素与2型糖尿病合并冠心病的相关性,探讨抵抗素对2型糖尿病合并冠心病的作用和机制。方法选择正常对照组51例,2型糖尿病组72例和2型糖尿病合并冠心病组75例,测定抵抗素、糖化血红蛋白、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、空腹血糖、空腹胰岛素。结果血清抵抗素浓度与年龄、SBP、DBP、TG呈正相关;与BMI、HOMA—IR等无相关性。结论抵抗素水平的升高与2型糖尿病合并冠心病形成有关。     

RELMs家族及其生物学功能研究进展

1RELMs家族成员及其结构特征自2001年发现小鼠抵抗素(resistin)具有胰岛素抵抗的生物学功能以来[1],RELMs家族成员相继被发现。目前,已发现的RELMs成员包括:小鼠和大鼠resistin、RELMα、RELMβ及RELMγ;猪resis-tin[2];人类resistin和RELMβ[3,4]。RELMs由105-114个氨基酸组成     

抵抗素在类风湿关节炎中的作用

虽然类风湿关节炎的发生与炎症有着密不可分的关系,但肥胖现象越来越多的发生在类风湿关节炎患者身上,随着进一步研究发现,肥胖也是一种初级炎症状态,类风湿关节炎、脂肪、炎症三者之间的关系引起了人们的重视。因此,从与炎症相关的脂肪因子——抵抗素入手,作为构建肥胖与类风湿关节炎疾病关系的桥梁,分析其在类风湿关节炎中的作用。     

Relations of Serum Visfatin and Resistin Levels with Endometrial Cancer and Factors Associated with its Prognosis

Background: The aims of this study were compare the serum visfatin and resistin levels between endometrialcancer (EC) patients and controls and evaluate their power to predict prognosis. Materials and Methods: Thisprospective study was conducted between March 2013 to June 2014 on the Gynecologic Oncology Departmentof the University of Selcuk, Konya, Turkey. A total of 42 EC patients and 42 controls were included and assessedfor differences in serum visfatin and resistin levels, along with prognostic factors. Results: Endometrial cancerpatients had significantly higher visfatin levels than control s (p: 0.011), associated with deep myometrial invasion(p: 0.019). In contrast the serum level of resistin did not significantly differ between EC patients and controls (p:0.362). However, high resistin level in EC patients was associated with increase lymph node metastasis (p: 0.009).On logistic regression analysis, we found that serum visfatin elevation was associated with risk of myometrialinvasion (OR: 1,091; 95%CI: 1.021- 1.166; p: 0.010) and serum resistin with risk of lymph node metastasis(OR: 1.018; 95%CI: 1.000- 1.035; p: 0.046). For myometrial invasion prediction, a serum visfatin level greaterthan 26.8 ng/mL demonstrated a sensitivity and specificity of 66.6 % and 96.4%, respectively. For lymph nodemetastasis prediction, the best cut-off for serum resistin level was 599ng/mL. A serum resistin level greater thanthis demonstrated a sensitivity and specificity of 87.5% and 77.1%, respectively. Conclusions: Our data suggestthat serum visfatin is elevated in patients with EC and serum visfatin and resistin levels could be used to predictthe risk of advance stage lesions.     

Circulating Levels of Adipocytokines as Potential Biomarkers for Early Detection of Colorectal Carcinoma in Egyptian Patients

Background: Early detection of various kinds of cancers nowadays is needed including colorectal cancerdue to the highly significant effects in improving cancer treatment. The aim of this study was to evaluate thepotential value of adiponectin, visfatin and resistin as early biomarkers for colorectal cancer patients. Materialsand Methods: Serum levels of adiponectin, visfatin and resistin were measured by a sandwich-enzyme-linked(ELISA) assay technique in 114 serum samples comprising 34 patients with colorectal cancer (CRC), 27 withcolonic polyps (CP), 24 with inflammatory bowel disease (IBD) and 29 healthy controls .The diagnostic accuracyof each serum marker was evaluated using receiver-operating characteristic (ROC) curve analysis. Results:The mean concentration of adiponectin was significantly higher in CRC and CP groups than IBD and controlgroups (P-value <0.05). Also the mean concentration of serum resistin was significantly elevated in the IBD andcontrol groups compared to CRC and CP groups (P-value = 0.014). However, no significant difference was notedin patients of the CRC and CP groups. On the other hand, the mean concentration of visfatin was significantlyelevated in CRC and control groups compared to CP and IBD groups (P-value = 0.03). ROC analysis curves forthe studied markers revealed that between CRC and IBD groups serum level of adiponectin had a sensitivity of76.7% and a specificity of 76% at a cut off value of 3940, +LR being 3.2 and –LR 0.31 with AUC 0.852, while serumlevel of adiponectin between CP and IBD had a sensitivity of 77.8% and a specificity of 75% at a cut off value of3300, with +LR=3.11 and -LR = 0.3 with AUC 0.852. On the other hand the serum level of visfatin between CRCand CP groups had a sensitivity of 65.5% and a specificity of 66.7 at a cut off value of 2.4, +LR being 1.67 and-LR 0.52 with AUC 0.698. Also the serum level of resistin had a sensitivity of 62.5% and a specificity of 70.3%at a cut off value of 24500, with +LR=2.1 and -LR = 0.53 with AUC 0.685 between control and other groups.On the other hand by comparing control vs CP groups resistin had a sensitivity of 81.8% and a specificity of70.8% at a cut off value of 17700, with +LR=2.8 and -LR = 0.26 with AUC 0.763 while visfatin had a sensitivityof 68.2% and a specificity of 70.8% at a cut off value of 2.7, with +LR=2.34 and -LR = 0.0.45 with AUC 0.812.Conclusions: These findings support potential roles of adiponectin, visfatin and resistin in early detection ofCRC and discrimination of different groups of CRC, CP or IBD patients from normal healthy individuals.