Determination of residual Kryptofix 2.2.2 levels in [F]-labeled radiopharmaceuticals for human use

4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (Kryptofix^® 2.2.2) is used in the routine preparation of [¹⁸F]-labeled tracers employed in positron emission tomography (PET) imaging. Confirming the absence of Kryptofix^® in radiopharmaceuticals is a quality control criterion required before they can be released for human use. Analysis of Kryptofix^® levels using the iodoplatinate spot-test can be complicated by false-positive results due to nitrogen containing tracers and/or false-negative results caused by added stabilizers. To overcome this issue, we have developed a universal TLC method for the rapid and reliable determination of Kryptofix^® levels in the wide range of fluorine-18 radiopharmaceuticals we prepare, including complex multi-component formulations.     

Induced abortion in China and the advances of post abortion family planning service

<正>This is a review of current situation of induced abortion and post abortion family planning service in China. Induced abortion is an important issue in reproductive health. This article reviewed the distribution of induced abortion in various time, areas, and population in China, and explored the character, reason, and harm to reproductive health of induced abortion. Furthermore, this article introduces the concept of Quality of Care Program in Family Planning, and discusses how important and necessary it is to introduce Quality of Care Program in Family Planning to China.     

东莞市正常儿童头发中微量元素含量参考值的研究

目的探讨东莞市区幼儿园3～7岁学龄前正常儿童头发中微量元素含量均值,以此作为东莞市区儿童头发中微量元素正常参考值.方法采取在群体自愿参加者中,选出经体检无重要脏器病变,营养一般,身高、体重在均值以上(称正常儿童).在枕后贴发根部剪0.5g头发检测其锌、铁、钙、铜、锰、铅元素含量.结果在1125例受检儿童中(称普查儿,占适龄儿95%).筛选出621例儿童,占总受检儿童的55.2%.这621例正常儿中,他们头发中锌、铁、钙、铜、锰、铅元素的含量分别为:93.473μg/g、29.710μg/g、779.50μg/g、9.773μg/g、3.222μg/g、9.251μg/g.结论检测的结果显示,2003年东莞市区正常儿童与2003年普查儿童相比,正常儿童发中微量元素含量明显升高,但差异无统计学意义.2003年东莞市正常儿童发中微量元素均值与广州市正常儿童相比,显著低于广州市正常儿童.由此可见,正常儿童发中微量元素含量均值受地域影响而有较大差异.东莞市区儿童发中微量元素含量应参照东莞市正常儿童发中微量元素含量均值较为合理.     

中小型图书馆文献编目质量规范控制探讨

分析了中小型图书馆文献编目质量规范方面的问题,对提高编目人员的规范意识、编目数据著录规范、学习与使用标目法与机读目录格式、数据格式标准化及标目规范控制工作范围、制定编目规范控制细则等五个方面进行了探讨.     

医学生素质教育中几对关系的处理

当医学素质教育中广博、个性、创新等观念日益被教育者和教育对象接受的同时，常常又容易陷入另一个误区，即盲目接纳、肯定这些观念，高没有对其进行审慎、辩证的思考，文章通过素质教育中几对观念的辨析，以期对此形成客观、全面的认识。     

Age-specific cerebral perfusion in 4- to 15-year-old children: a high-resolution brain SPET study using 99mTc-ECD

This study addresses the question of whether the normal range for distribution of local cerebral blood flow (lCBF) in adults can be transferred to the 4- to 15-year-old age group. Twenty-three children (age: 4–15 years; mean 11±3 years, group I) and 10 adults (age: 27–56 years; mean 45±10 years, group II) without evidence of cerebrovascular disease or other brain diseases underwent technetium-99m ethyl cysteinate dimer single-photon emission tomography. Counts in cortical and subcortical regions of interest (ROIs) were related to those in cerebellar ROIs (= 100%). Relative cortical activity in group I exceeded that in group II, particularly in left parietal (107.6%±9.8% vs 84.1%±12.4%), left frontal (97.7%±6.7% vs 79.4%±8.9%) and left temporal areas (99.7%±7.4% vs 84.9%±10.1%) and in the cingulate cortex (112.1%±9.1% vs 95.9%±10.1%, P<0.05). Cerebral activity uptake per injected dose was inversely correlated with age in 19 children of group I (r = –0.77, P<0.001). In group I, there was also an inverse correlation between age and the relative local count density in the parietal (r = –0.42 to –0.57), frontal (r = –0.48), temporal (r = –0.42 to –0.58) and occipital cortex (r = –0.44). In these cortical regions relative counts differed when subgroups of children aged 4–10 and 11–15 years were analysed. It is concluded that there are systematic differences between 4- to 15-year-old children and adults with regard to normal lCBF. Diagnostic use of perfusion agents has to consider age-adjusted normal flow maps; normal ranges should be determined separately for the age groups 4–10 and 11–15 years. Received 23 March and in revised form 11 July 1997     

均一吸收体中SPECT重建多解性的探讨

通过对重建图像噪声特性的分析，间接证明ＳＰＥＣＴ的解具有多样性。分别用ＴｒｅｔｉａｋＭｅｔｚ、Ｇｕｌｂｅｒｇ、富谷武浩等推导的３种等价重建方法和Ｂｅｌｉｎｉ等推导的重建方法，经计算机模拟重建衰减均匀分布的图像，先预置相同的重建图像的空间分辨率，再比较它们的噪声特性。两种方法重建图像的噪声分布：前者近图像边缘时增大，而后者减小，从而间接证明在假定均匀衰减条件下，ＳＰＥＣＴ的重建有多解性。     

21世纪加强医学生人文素质培养的思考

医学科学从来就是科学知识与人文精神密切结合的一门学科。现代科学技术越来越多地应用于医学研究和医学实践,大大地促进了医学科学的发展,然而也呼唤着更多的医学人文精神的关怀。如何把医学科学知识与医学人文精神有机地结合起来,是我国医学院校教育的重要课题。