高频部分液体通气对吸入伤犬呼吸循环功能的影响

目的　观察高频部分液体通气 (highfrequencypartialliquidventilation ,HFPLV)对吸入性损伤犬肺力学、氧合和血流动力学参数的影响。　方法　 16条犬经吸入蒸气 ,造成重度吸入性损伤模型 ,并随机分为对照组和治疗组。两组动物致伤后均行高频喷射通气 (highfrequencyjetventila tiot,HFJV) ,治疗组同时经气管导管缓慢注入氟碳液体 (3ml/kg体重 ) ,行HFPLV治疗 ,于通气后3 0、60和 90min时测定两组动物血气、肺顺应性、气道阻力及血流动力学参数。　结果　治疗组PaO2 呈进行性上升 ,在各时相点与致伤后比较差异有显著性意义 (P <0 .0 5 ) ,而对照组各时相点与致伤后比较差异无显著性意义 (P >0 .0 5 ) ;治疗组PaCO2 也逐渐增高 ,于 60、90min显著高于致伤后水平 (P <0 .0 5 )。与对照组比较 ,治疗组各时相点的PaO2 稍有升高 (P >0 .0 5 ) ,PaCO2 于 90min显著增高 (P <0 .0 5 ) ,而两组动 /静态气道阻力、肺顺应性和血流动力学参数比较 ,差异均无显著性意义 (P >0 .0 5 )。　结论　HFPLV与单纯HFJV相比 ,更有利于吸入性损伤的动脉氧合 ,对血流动力学参数无明显不利影响     

高效液相色谱法测定毛支清口服液中黄芩苷含量

目的建立毛支清口服液中黄芩苷含量的测定方法。方法选用Venusil MP C18分析柱（4.6 mm×250 mm,5μm）,甲醇-水-磷酸（60∶40∶0.2）为流动相,检测波长为280 nm,流速为1.0 ml/min。结果黄芩苷进样量为0.5~3.0μg时与峰面积具有良好的线性关系,回归方程为：Y=3.00×106X-415 373,r=0.999 6,平均回收率为103.0%,相对标准偏差为1.117%。结论所建立的高效液相色谱方法简便、准确、灵敏度高、分离效果好,可作为毛支清口服液的质量控制标准。     

改进抽吸中药针剂产生泡沫和药液流洒的对比研究

目的探讨改进抽吸中药针剂产生泡沫和药液流洒的临床效果。方法教材中抽吸药液方法为传统法,临床实用抽吸药液方法为改进法。由技术相当的专业护理人员进行抽取中药针剂,抽吸2 mL醒脑静注射液500次,抽吸10 mL清开灵注射液500次。比较两种方法抽吸中药针剂产生泡沫和药液流洒情况。结果改进法抽吸醒脑静注射液产生泡沫次数和药液流洒总量明显小于传统法,差异均有高度统计学意义（均P〈0.01）。改进法抽吸清开灵注射液产生泡沫次数和药液流洒总量明显小于传统法,差异均有高度统计学意义（均P〈0.01）。结论改进法不仅可以明显减少泡沫产生,还可以减少药液流洒,减少药液浪费,是一种安全有效的抽吸方法,值得临床推广使用。     

Ion transfer voltammetry of tryptamine,serotonin, and tryptophan at the nitrobenzene/water interface

The transfer of the cationic forms of tryptamine and serotonin across the nitrobenzene (NB)/water (W) interface was studied by cyclic voltammetry. Well-defined voltammetric waves were observed within the potential window. The standard potentials of the transfer were determined from the midpoint potentials of the voltammograms. The transfer of the cationic form of tryptophan across the NB/W interface was also observed using an acidic aqueous solution.     

婴幼儿带状疱疹6例

报告6例婴幼儿带状疱疹。男1例,女5例;年龄5个月~3岁;病程3~5 d。皮损符合带状疱疹特征,红斑、水疱呈簇集带状单侧分布,其中耳带状疱疹1例。在常规抗病毒综合治疗同时给予液氮冷喷擦拭和复方紫草油外用,疗效显著。     

改良封管液在血液透析中的应用效果

目的 探讨改良封管液在长期性双腔透析导管血透患者中的应用效果.方法 将180例使用长期性双腔透析导管行血液透析的患者随机分为实验组和对照组,每组各90例.实验组于透析结束后采用尿激酶10000U＋氨苄西林钠1g ＋肝素50mg＋NS,进行封管,对照组于每次透析结束后采用纯肝素50mg＋NS进行封管.3个月后观察2组患者导管相关性感染和血栓的发生率.结果 3个月后,实验组患者导管相关性感染发生率为0 00%.对照组为8.89%（χ2=6.41,P〈0.05）;实验组患者血栓的发生率0 00%,对照组为6.67%（χ2=4.31,P〈0.05）,实验组患者导管相关性感染和血栓发生率均低于对照组.结论 改良封管液不仅可以较好地预防导管相关性感染,同时还可以降低血栓的发生率.     

Liquid scintillation counting of polycarbonates: A sensitive technique for measurement of activity concentration of some radioactive noble gases

This work explores the application of the liquid scintillation counting of polycarbonates for measurement of the activity concentration of radioactive noble gases. Results from experimental studies of the method are presented. Potential applications in the monitoring of radioactive noble gases are discussed.     

HPLC法测定双丹口服液中丹皮酚的含量

目的建立高效液相色谱法测定双丹口服液中丹皮酚含量的方法。方法采用Zorbax SB-C18(4.6mm×250mm,5μm)色谱柱,甲醇-水(65∶35)为流动相,流速1.0mL.min-1,检测波长为274nm。结果丹皮酚线性范围为0.214~1.069μg,平均回收率为98.36%,RSD为0.36%。结论该方法简便、可靠、准确,可用于该制剂的质量控制。     

Evaluation of free radical scavenging and antityrosinase activities of standardized longan fruit extract.

The protective effects of fruits and vegetables against chronic diseases have been attributed to the antioxidant properties of some secondary metabolites present in these foods. Plant polyphenols have been reported to exhibit bioactive properties, and in particular antioxidant activities. Longan seeds are found to contain high levels of some beneficial polyphenolic compounds such as corilagin, gallic acid and ellagic acid. The present study examined the free radical scavenging activity of longan seed extract by using three different assay methods. Longan extracts contained corilagin ranging from zero to 50.64 mg/g DW, gallic acid from 9.18 to 23.04 mg/g DW, and ellagic acid from 8.13 to 12.65 mg/g DW depending on the cultivars. Dried longan seed extracts of cultivar Edor contained high levels of gallic acid and ellagic acid and also exhibited the highest radical scavenging activities when comparing fresh seed and dried pulp extracts. For scavenging activity of DPPH and superoxide radicals, longan seed extract was found to be as effective as Japanese green tea extract while dried longan pulp and mulberry green tea extracts showed the least scavenging activities. In the ORAC assay, both fresh and dried longan seed also had higher activity than dried pulp and whole fruit. However, the results demonstrate that three polyphenolics may not be the major contributors of the high antioxidant activity of longan water extracts but this high activity may be due to other phenolic/flavonoid glycosides and ellagitannins present in longan fruit. In addition, longan seed also showed tyrosinase inhibitory activity with IC(50) values of 2.9-3.2 mg/ml. Therefore, the preliminary observations suggest that longan seed extract could be another potential source of potent natural dietary antioxidants and also in an application as a new natural skin-whitening agent.     

液体口服制剂分剂量准确性分析

目的:探讨液体口服制剂分剂量的准确性。方法:对我院目前使用的液体口服制剂进行调查,并对苯海拉明合剂、氯雷他定糖浆、盐酸班布特罗口服液、丙戊酸钠糖浆4种液体口服制剂按3种常用分剂量方法取样,将取样结果进行准确性统计分析。结果:药品取样量越小,准确性越低;不同的取样标准取样体积相对标准差不同,以药瓶刻度线为取样标准的准确度最低。结论:应改进液体口服制剂分剂量包装。