Surgical suture assembled with polymeric drug-delivery sheet for sustained,local pain relief

Surgical suture is a strand of biocompatible material designed for wound closure, and therefore can be a medical device potentially suitable for local drug delivery to treat pain at the surgical site. However, the preparation methods previously introduced for drug-delivery sutures adversely influenced the mechanical strength of the suture itself – strength that is essential for successful wound closure. Thus, it is not easy to control drug delivery with sutures, and the drug-delivery surgical sutures available for clinical use are now limited to anti-infection roles. Here, we demonstrate a surgical suture enabled to provide controlled delivery of a pain-relief drug and, more importantly, we demonstrate how it can be fabricated to maintain the mechanical strength of the suture itself. For this purpose, we separately prepare a drug-delivery sheet composed of a biocompatible polymer and a pain-relief drug, which is then physically assembled with a type of surgical suture that is already in clinical use. In this way, the drug release profiles can be tailored for the period of therapeutic need by modifying only the drug-loaded polymer sheet without adversely influencing the mechanical strength of the suture. The drug-delivery sutures in this work can effectively relieve the pain at the surgical site in a sustained manner during the period of wound healing, while showing biocompatibility and mechanical properties comparable to those of the original surgical suture in clinical use.     

改良缝合法结合克氏针内固定治疗锤状指的疗效分析

目的探讨改良缝合法治疗锤状指的临床疗效。方法对我院2010年6月~2011年7月间收治的23例锤状指患者采用Bunnell双针缝线缝合伸肌腱后,打结固定于指腹的改良缝合法结合克氏针固定的手术方法治疗。术后不用外固定,6w后拔除克氏针开始功能锻炼。结果 1例术后2m因线结反应发生切口感染,锤状指畸形复发;其余患者切口均Ⅰ期愈合。23例患者均获随访,随访时间12~24m。末次随访时,采用Crawford功能评定标准:优12例,良9例,可1例,差1例,优良率91.3%。结论改良缝合法是治疗锤状指简便、有效方法。     

关节镜下半月板前角缝合器在半月板损伤中的临床应用

目的探讨关节镜下使用半月板前角缝合器修复半月板损伤的临床效果。方法对53例半月板前体部损伤患者,应用半月板前角缝合器行关节镜下由外向内缝合术。结果50例患者获随访,时间6～36个月,患者疼痛等症状明显好转。按HSS评分系统,由术前平均（45．2±6．5）分提高至术后平均（88．2±5．8）分（P〈0．05）。结论应用半月板前角缝合器对半月板前体部损伤行由外向内缝合术,损伤小,疗效好,近期效果满意。     

踝关节内侧韧带损伤的治疗

目的 探讨带线锚钉修补踝关节内侧韧带损伤的临床疗效.方法对18例踝关节内侧韧带结构损伤的患者行切开带线锚钉修补手术.结果 18例均得到随访,时间12～24个月.X线片显示胫距关节间隙正常.Baird踝关节功能评分为91～98（93.44±4.91）分,优12例,良6例.结论 带线锚钉修补踝关节内侧韧带损伤操作简单,可以避免踝关节不稳,疗效良好.     

Bending and abrasion fatigue of common suture materials used in arthroscopic and open orthopedic surgery

In orthopedic surgery, the reattachment of tendon to bone requires suture materials that have stable and durable properties to allow time for healing at the tendon–bone interface. The suture, not rigidly restrained within the anchor eyelet, is free to move during surgery and potentially after surgery with limb motion. During such movement, the suture is subjected to bending and frictional forces that can lead to fatigue‐induced failure. We investigated some common contemporary commercial number‐two‐grade suture materials and evaluated their resistance to bending abrasion fatigue and the consequent failure. Sutures were oscillated over a stainless steel wire at low frequency under load. Number of abrasion cycles to failure, changes in suture morphology, and fatigue‐failure method was recorded for each material. Suture structure had a significant effect on abrasion resistance, with braided sutures containing large numbers of fine high tenacity core filaments performing15–20 times better than other braided suture structures. Ultra high molecular weight polyethylene (UHMWPE) core filaments resisted bending abrasion failure better than other core materials due to the load spreading and abrasion resistance of these filaments. Sutures with UHMWPE cores also had high resistance to tensile failure. Limited correlation was observed between tensile strength and abrasion resistance. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:132–138, 2012     

Tetraparesis as clinical correlate of subacute cervical flexion myelopathy

Context: We report the case of a 20-year-old woman who underwent tracheal resection with postoperative chin-to-chest suture for 10 days, presenting with severe tetraparesis at our institution. Similar cases have been reported previously, however, not yet in the pathophysiological context of chronic cervical flexion myelopathy (Hirayama syndrome).

Findings: Extensive myelopathy at cervical level is the consequence of the fixed cervical spine position due to chin-to-chest suture. Predominantly affected young individuals (age range from 20–25 years) without evidence of degenerated spine disease suggest a similar mechanism as described in Hirayama syndrome—displacement of the dura with consecutive compression of the spinal cord vasculature.

Conclusions: Subacute flexion myelopathy represents a serious complication of operative/postoperative fixed cervical spine positions, warranting particular attention by respective surgeons.     

Catastrophic failure of an uncemented acetabular component due to high wear and osteolysisAn analysis of 154 Omnifit prostheses with mean 6-year follow-up

Background?The purposes of this study were (1) to evaluate the wear pattern of the hydroxyapatite-coated “Dual Radius” Omnifit cup, (2) to investigate whether wear is correlated to any demographic or prosthesis-related factors, and (3) to describe micromotion of both the cup and the stem.Patients and methods?154 hips were implanted between 1990 and 1996 and followed for an average of 6 years. Wear was measured according to the “Charnley-duo” method and, in 79 hips, with radiostereometry (RSA). RSA was also used to evaluate micromotion. We analyzed the femoral heads using scanning electron microscopy, energy dispersive X-ray spectroscopy and an atomic force microscope.Result?66 cups were revised and had a mean annual wear of 0.32?mm compared to 0.12?mm in hips not revised. Osteolytic processes were observed in 35 hips but at revision osteolysis was present in 51 cases. 43/66 sockets were loose. Micromotion evaluated by RSA, weight, age, side, size of cup, screws, polyethylene thickness or shelf-life of the polyethylene did not correlate to wear, whereas male gender did.Interpretation?It is still unclear why about half of our cases had an abnormal wear rate. Annual wear exceeding 0.2?mm is prognostic of late failure and should be considered a warning sign.     

子宫网压缝合术在难治性产后出血中的初步应用

目的:探讨子宫网压缝合术在难治性产后出血治疗中的应用价值。方法:回顾分析子宫网压缝合术对5例难治性产后出血患者的临床治疗,评价手术疗效及手术安全性。结果:经子宫按摩、促宫缩药物注射、宫腔纱条填塞、子宫动脉结扎或B-Lynch缝合等措施处理仍无法止血的5例宫缩乏力性产后出血患者,行子宫网压缝合术后,子宫活动性出血5~10分钟内停止,观察30分钟阴道无明显流血关腹,均成功止血并保留子宫。术后5天垂体激素、甲状腺激素、肾上腺激素及女性激素各项数值均在正常范围;磁共振成像(MRI)检查:术后4天宫壁见散在点状信号,未见宫腔积液;术后46天宫壁肌层信号均匀,宫内膜线清晰。超声检查:术后42天子宫前后径3.5~4.5 cm,宫壁肌层回声均匀,复旧形态良好。宫腔镜检查:术后5个月,宫腔无粘连,内膜形态正常,输卵管开口清晰。随访:例5在哺乳期,其余病例停止哺乳后1~2个月月经恢复正常;例2术后20个月再次妊娠,术后29个月经剖宫产诞下1健康女婴。结论:对经子宫按摩、促宫缩药物注射、宫腔纱条填塞、子宫动脉结扎及B-Lynch缝合等措施处理仍无法止血的宫缩乏力性产后出血患者,子宫网压缝合术治疗安全有效,可以考虑作为治疗难治性产后出血的一种止血方式。     

前壁切除联合改良荷包缝合加压固定治疗复发及复杂性耳廓假性囊肿

耳廓假性囊肿是耳廓软骨间的无菌性浆液性渗出性炎症,常表现为耳廓表面出现一个半球形的无痛囊性隆起。目前对耳廓假性囊肿的临床治疗方法多样,缺乏统一,且多疗效欠佳,复发率较高,可遗留耳廓增厚、变形等后遗症[1]。本研究采用前壁切除联合改良荷包缝合加压固定术治疗复发及复杂性耳廓假性囊肿26例,取得满意疗效,现总结报道如下。     

关节镜下治疗前交叉韧带胫骨止点撕脱骨折

正2010年7月~2015年2月,我科采用关节镜下Orthocord线治疗32例前交叉韧带胫骨止点撕脱骨折患者,疗效良好,报道如下。1材料与方法1.1病例资料本组32例,男18例,女14例,年龄13~61岁。根据MeyersMc Keever分型:Ⅱ型16例,Ⅲ型12例,Ⅳ型4例。新鲜骨折29例,陈旧性骨折