Nitroglycerin patch for the treatment of chondrodermatitis nodularis helicis: a new therapeutic option

Chondrodermatitis nodularis helicis (CNH) is an inflammatory process that affects the skin and cartilage of the ear. At present, there are many treatment options, although they are not always effective. Based on previous studies where nitroglycerin 2% gel was used, we propose the use of nitroglycerin patches. The purpose of this study was to evaluate the effectiveness of nitroglycerin patches in treating CNH. We performed a prospective study in 11 patients diagnosed with CNH treated with nitroglycerin patches 5 mg, 12 hours a day for 2 months. The therapeutic effectivity was determined by the improvement in the appearance and symptoms of the lesion. Seven of 11 patients (63.6%) had a complete response. One of 11 patients (9%) did not respond completely and surgical treatment was performed. Two of 11 patients (18.1%) stopped the treatment because of headache. One of 11 patients (9%) did not complete the treatment because the said patient forgot to apply the patch every night. Transdermal nitroglycerin has demonstrated efficacy in the treatment of the symptoms and lesional appearance of CNH noninvasive manner. The success rate is comparable with other published methods and the rate of adverse effects is acceptable.     

透皮贴剂市场研究及其新进展

目的：对透皮贴剂进行市场研究及分析，并介绍国内透皮给药研究的最新进展，为透皮贴荆的销售市场及其新药研究提供参考。结论；透皮给药系统具有广阔的市场和开发前景。     

妥洛特罗贴剂治疗婴幼儿哮喘30例的疗效

目的观察妥洛特罗贴剂治疗婴幼儿哮喘的临床疗效。方法选择在江西省儿童医院呼吸科住院治疗的婴幼儿哮喘患儿60例,按随机数字表法分为观察组和对照组,每组30例。2组在常规治疗的基础上,观察组给予妥洛特罗贴片（阿米迪贴剂）0.5 mg.贴-1,每日20：00～21：00贴于前胸或后背处,每日更换部位;对照组给予硫酸特布他林2.5 mg＋生理盐水2 mL予6 L.min-1氧气驱动雾化吸入,2次.d-1。2组均5 d为1个疗程。观察2组患儿咳嗽、喘息、哮鸣音消失时间,住院时间,气道阻力的变化及药物的不良反应。结果 2组治疗5 d后咳嗽、喘息、哮鸣音消失及住院时间的比较差异均无统计学意义（均P〉0.05）;2组治疗后气道阻力与治疗前比较均有明显下降（均P〈0.05）;2组治疗前后气道阻力变化的比较差异均无统计学意义（均P〉0.05）。观察组出现局部皮肤瘙痒1例,通过更换妥洛特罗贴片的粘贴部位完成治疗,无全身不良反应。结论妥洛特罗贴剂治疗婴幼儿哮喘与特布他林雾化吸入治疗临床效果一致,且无严重不良反应发生,是一种安全有效的新型哮喘治疗药物。