过萌磨牙牙周组织内应力分布的有限元研究

目的：探讨牙齿过萌与其周围生物力学环境变化之间的内在联系。方法：用二维有限元法分析阻萌力减少前后下第一磨牙牙周组织内应力分布的变化。结果：牙周膜内的应力分布随阻萌力的变化而改变，并具有明显的规律性。结论：阻萌力下降所致牙周膜内压应力值的降低或拉应力值的出现与过萌牙牙槽骨的骨质沉积加快必然有着某种内在的联系。     

纤维调节素在牙周损伤愈合中的免疫化学定位和表达

目的:研究纤维调节素在牙周组织损伤愈合过程中的免疫化学定位。方法:损伤成年鼠磨牙周围的牙周组织,跟踪28 d,对纤维调节素和Ⅰ型、Ⅲ型胶原在愈合过程中的免疫组织化学分布进行分析。结果:纤维调节素在结缔组织中的免疫组织化学分布与Ⅲ型胶原相似。在牙周损伤愈合早期,纤维调节素分布于损伤区周围的纤维束,特别是损伤的牙槽骨和牙根表面之间的区域,在移行的牙龈上皮细胞中表达明显。愈合中期,纤维调节素广泛表达于肉芽组织成纤维细胞及其基质。愈合晚期,纤维调节素表达于牙骨质和新骨交界处的主纤维。结论:在牙周损伤愈合过程中,纤维调节素可能参与早期胶原纤维生成和对牙骨质和骨的再附着,在组织愈合的早期活动中起重要作用。     

Biologic Perspectives in Restorative Treatment

One of the primary goals of a long term successful restorative therapy is to establish a physiologic periodontal climate that facilitates the maintenance of periodontal health. The contemporary clinician has a host of alternatives for the restoration of teeth. It is now possible to mimic nature and provide restorations that defy detection but the most challenging procedure in clinical dentistry is fabricating a restoration in gingival harmony. Periodontal health is the basis of all restorative dentistry. Because periodontal disease is a major cause of tooth loss in adults, the clinician must be aware of the biological variables relevant to restorative therapy, basic concepts and clinical modes of therapy available, to be able to develop an appropriate diagnosis and treatment plan. A natural looking prosthesis within a healthy periodontium should represent the ultimate goal. This article addresses the interactions between periodontal tissues and restorative procedures. It reviews the essentials of soft tissue management inherent in restorative dentistry that will increase the probability of a successful restoration.     

正畸牙移动过程中血小板源性生长因子-BB在牙周组织中的表达

目的观察正畸牙移动过程中血小板源性生长因子（platelet—derived growth factor,PDGF）．BB在牙周组织中的表达分布情况,探讨其与牙周组织改建的关系。方法36只Wistar大鼠随机分为加力1d、3d、7d、14d、21d组及对照组。建立正畸牙移动模型,采用苏木素-伊红染色和免疫组化法,对PDGF—BB半定量、定位分析。结果PDGF-BB主要定位于成纤维细胞、成骨细胞、破骨细胞、血管内皮细胞,施力后表达显著增强,压力侧加力第7天达峰值,张力侧加力第14天达峰值,此后表达下降。结论PDGF-BB作为局部调控因子参与了正畸牙周组织改建过程。     

Rapid maxillary expansion causes neuronal activation in brain structures of rats

A correlation between pain sensation and neuronal c-fos expression has been analyzed following experimental rapid maxillar expansion (RME).Adult male Wistar rats were anaesthetized and divided into three groups: animals that received an orthodontic apparatus, which was immediately removed after the insertion (control), animals that received an inactivated orthodontic apparatus (without force), and animals that received an orthodontic apparatus previously activated (140 g force). After 6, 24, 48, or 72 h, the animals were re-anaesthetized, and perfused with 4% paraformaldehyde.The brains were removed, fixed, and sections containing brain structures related to nociception were processed for Fos protein immunohistochemistry (IHC). The insertion of the orthodontic apparatus with 140 g was able to cause RME that could be seen by radiography. The IHC results showed that the number of activated neurons in the different nuclei changed according to the duration of appliance insertion and followed a temporal pattern similar to that of sensations described in clinics. The animals that received the orthodontic apparatus without force did not show RME but a smaller c-fos expression in the same brain structures. In conclusion, we demonstrate that orthodontic force used for palate disjunction activates brain structures that are related to nociception, and that this activation is related to the pain sensation described during orthodontic treatment.     

胰岛素样生长因子在正畸牙牙周组织改建中的作用

背景：正畸牙牙周组织改建主要是牙槽骨的改建。胰岛素样生长因子是牙周组织改建的重要因子,它在细胞的增殖、分化及个体的生长发育中发挥着重要的促进作用。 目的：综述胰岛素样生长因子在牙周组织改建中的作用。 方法：运用计算机检索PubMed,中国知网以及贵州省数字图书馆等数据库,查阅至今有关胰岛素样生长因子在牙周组织改建中作用的中英文文献。关键词“胰岛素样生长因子;牙周组织;改建;insulin-like growth factor;Periodontal tissue;remodeling”。纳入胰岛素样生长因子与牙周组织改建中作用相关的文献进行归纳分析。 结果与结论：胰岛素样生长因子属于胰岛素家族的一类多肽,对牙周膜中的成骨细胞、成纤维细胞以及诱导间充质细胞等,有促进其细胞迁移、增殖、分化、胶原和基质合成、增强碱性磷酸酶活性及在损伤修复中发挥着重要作用。在正畸治疗中,使用适宜矫治力的同时可适当运用能促进牙周组织改建的胰岛素样生长因子,加快正畸牙齿的移动,缩短患者的矫治时间。  中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程     

正畸力作用下牙周炎大鼠张力侧牙周组织中转化生长因子β1基因表达的研究

目的研究炎性牙周条件下牙移动及牙周改建中转化生长因子（transforming growth factor-β1,TGF—β1）基因的表达。方法90只雄性SD大鼠随机分为为正常牙移动组、牙周炎牙移动组,对大鼠上颌第一磨牙近中移动,在0、0．5、1、2、3、5、7、14、21d时间点处死动物,运用原位杂交方法,检测牙移动张力侧TGF—β1 mRNA表达强度及时空分布特点。结果正常及牙周炎大鼠牙周组织中,TGF-β1 mRNA在牙周膜成纤维细胞、成骨细胞和骨髓组织中呈弱阳性表达,正常大鼠牙齿受力2d后,张力侧牙槽骨表面成骨细胞中TGF-β1 mRNA的表达明显增加,5d达到峰值;牙周炎大鼠牙移动5d后,其牙槽骨表面立方形成骨细胞TGF—β1 mRNA的表达明显增加,14d达到高峰期,21d还有较强的阳性信号表达。结论牙周炎可能阻碍正畸力效应下的牙周组织改建。     

Donor–host tissue interaction in allogenic transplanted tooth germ with special reference to periodontal tissue

Objectives

Limited biological evidence exists regarding donor–host interaction in the periodontal tissue during allogenic tooth germ transplantation. This study aimed to clarify donor–host tissue interactions during periodontal tissue healing following tooth germ transplantation.

口腔诊疗中的牙周基本检查评估规范

第四次全国口腔健康流行病学调查报告显示,我国牙周病患病率仍居高不下,牙周炎仍然是成年人牙齿丧失的主要原因。因此,如何早期规范化检查患者的牙周健康状况、确定其病情程度、进行预后的风险评估等尤为重要。中华口腔医学会牙周病学专业委员会组织相关专家,制定了口腔诊疗中的牙周基本检查评估规范,强调牙周健康评估的必要性、重要性和可行性;经中华口腔医学会标准委员会审批通过和正式发布,做为国家行业标准,有助于统一和提高口腔临床医师对牙周危害的认识、诊断和治疗方案设计,对于守护天然牙和提升全民口腔健康状况具有重要和深远的现实意义。     

牙周维护在固定正畸中的临床意义

目的 探讨牙周维护在固定正畸中的临床意义.方法 将该院口腔科近4年固定正畸患者36例随机分为A、B两组.A组为对照组,仅进行家庭常规口腔护理;B组为实验组,在正畸期间定期进行牙周维护.分不同时期观察两组各项矛周指标变化情况 结果 B组固定正畸矫治后与矫治前牙周各项指标比较无明显差异,但比A组牙周各项指标评分低,差异有统计学意义(P＜0.05) 结论 定期牙周维护可以降低患者固定正畸过程中牙周疾病的发生.