Experimentally induced infection by oral anaerobic microorganisms in a mouse model

A mouse model was developed to study the abscessogenic potential of pure and mixed cultures of oral anaerobes associated with infections of endodontic origin. Maximum subcutaneous lesions were seen on their backs between 3 and 14 d after inoculation. Strains of Fusobacterium nucleatum, Peptostreptococcus anaerobius, and Veillonella parvula were pathogenic in pure culture. A mixed culture of F. nucleatum with either Porphyromonas gingivalis or Prevotella intermedia was significantly more pathogenic than F. nucleatum in pure culture. Histopathological examination of tissue sections from control mice injected with India ink in the medium demonstrated a pathway of particulate migration from the backs of the mice to their abdomen.     

腹腔镜下腹部子宫悬吊术治疗不孕症32例临床分析

5年来（1989～1993）对患有子宫内膜异位症（EM）和盆腔炎性疾病（PID）的32例不孕症患者应用腹腔镜技术进行诊断与手术，并施行腹腔镜下腹部子宫悬吊术，术后针对病因用药物治疗。随访2～6年，总妊娠率56．3％（18／32）；活产率53．1％（17／32）；流产率3．1％（1／32）。其中EM术后妊娠率85％（11／13），PID46％（6／13），两组间差异极其显著（P＜0．01），说明EM组术后妊娠率极显著地高于PID组。提示：对于输卵管通畅的EM和PID不孕患者，腹腔镜下腹部子宫悬吊术不仅可以纠正后位子宫，防止术后再度粘连，消除或减轻疾病引起的症状，还可提高术后妊娠率，为EM与PID的不孕患者提供了一个新的腹腔镜手术，方法简单，容易掌握，不需增力。设备与器械，值得推广与应用。     

Interstitial cystitis in persistent posthysterectomy chronic pelvic pain.

OBJECTIVES: Hysterectomies may be performed unnecessarily in women with chronic pelvic pain if the diagnosis of interstitial cystitis is not considered. The objectives of this study were to investigate the prevalence of interstitial cystitis in patients with posthysterectomy chronic pelvic pain and to evaluate the efficacy of various therapies for interstitial cystitis. METHODS: A study was performed of 111 patients with chronic pelvic pain whose pain persisted after hysterectomy. Patients were screened with the Pelvic Pain and Urgency/Frequency symptom scale, and underwent Potassium Sensitivity Testing. Patients were treated with dietary changes alone or in combination with cystoscopic hydrodistention or oral pentosan polysulfate, or both of these, for 3 to 6 months. RESULTS: Of the 111 patients enrolled, 79% (n=88) were diagnosed with bladder dysfunction consistent with interstitial cystitis. For patients treated with dietary modification alone (n=33), the mean score on the Pelvic Pain and Urgency/Frequency questionnaire improved 15.4%, from 13.18 at baseline to 11.15 at follow-up. For patients treated with pentosan polysulfate or cystoscopic hydrodistention, or both, plus diet changes (n=78), Pelvic Pain and Urgency/Frequency scores improved 34.2%, from 15.01 to 9.87. CONCLUSION: In this study, nonsurgical treatment for interstitial cystitis resulted in a marked improvement in symptoms that had not improved with surgery. Without determining the origin of bladder pain, gynecologists should not proceed to hysterectomy in patients with chronic pelvic pain.     

肛周脓肿细菌感染菌群分布研究

①目的探讨肛周脓肿厌氧与需氧茵的菌群分布。②方法选择31例肛周脓肿患，对其脓液中的厌氧茵和需氧菌进行培养鉴定。③结果肛周脓肿感染患中男27例，女4例；感染中共分离出51株细菌，其中厌氧菌30株，需氧菌21株。厌氧菌总检出率为96．8％，需氧菌总检出率为67．4％。单纯厌氧菌感染检出率为32．3％，单纯需氧菌检出率为32％。、厌氧和需氧菌混合感染捡出率为64．5％。在所分离出的30株厌氧菌中，脆弱类杆菌占80％，消化链球菌占13％，普通类杆菌和产黑色素类杆菌各占33％21株需氧菌中，大肠杆菌占71％，肺炎克雷伯菌、产气肠杆菌、阴沟肠杆菌各占9．5％。④结论肛周脓肿男性患病率高于女性；细菌感染菌群分布以脆弱类杆菌和大肠杆菌为主；感染类型以厌氧和需氧菌混合感染居多。     

Pelvic neuroblastoma—Implications for a new favorable subgroup: A Children's cancer group experience

Background: The survival in neuroblastoma is influenced by patient age, disease stage, tumor site, and several biologic factors. This study was undertaken to determine if primary pelvic lesions are associated with an unusually favorable outcome. Methods: Nine hundred eighty-six patients registered on Children's Cancer Group studies from 1980 to 1993 were reviewed, and 41 (4.3%) were found to have pelvic tumors. Survival was analyzed, and correlations among age, stage of disease, surgical resectability, histopathology, serum ferritin, and N-myc oncogene amplification were evaluated. Results: Age at diagnosis was comparable between patients with pelvic and nonpelvic tumors. Disease distribution was similar, with stages III and IV comprising 78% (32 of 41) of pelvic lesions compared with 73% (692 of 945) for nonpelvic tumors. There was no outcome difference in favorable stages (I, II, and IV-S), with 3-year progression-free survival rates of 88% and 82% for pelvic and nonpelvic sites, respectively. However, in stages III and IV, the 3-year progression-free survival was 70% for pelvic lesions compared with 47% for nonpelvic tumors (p=0.04). Some favorable biologic factors were more common in children with pelvic lesions. Conclusions: The pelvis is an unusual primary site for neuroblastoma but represents a more favorable prognostic subgroup, which is most evident in advanced-stage disease. Presented at the 47th Annual Cancer Symposium of The Society of Surgical Oncology, Houston, Texas, March 17–20, 1994.     

肝癌经肝动脉栓塞术后癌灶化脓性感染的诊断和治疗

报道了７例肝癌经肝动脉栓塞术（ＴＡＥ）后合并感染、脓肿的病例。发生此一严重并发症的机率约为１．４％（７／４９５）。诊断主要依靠临床症状及ＣＴ、Ｂ超影像。在ＣＴ导向下的有效引流和对残癌组织用无水酒精冲洗则是最主要的治疗方法。其转归大概可分为：（１）脓肿痊愈、肿瘤姑息；（２）脓肿痊愈，活癌子灶仍存；（３）死于无法控制的感染。     

Prostatic abscess: CT and sonographic features

Prostatic abscess is not a common condition, but delay in the diagnosis may result in serious complications such as rupture of the abscess into the rectum or urethra resulting in a high morbidity. We present a case of clinically unsuspected prostatic abscess where computed tomography and transrectal sonography established the diagnosis. Correspondence to: A. A. Ghiatas     

Renal abscess in healthy children: report of three cases

We report three cases of renal abscess in otherwise healthy boys. One had a history of blunt trauma and two of antecedent skin infection. All presented with flank pain and fever. Urine and blood cultures were sterile. The diagnosis was made using ultrasound and computerized axial tomography. The first patient had recurrent renal abscess, following surgery and a short course of antibiotics. Eventually all responded well to long-term antibiotics only.     

肝脓肿的CT诊断

目的分析不同病理演变时期肝脓肿的CT表现,提高对肝脓肿的诊断水平。方法回顾分析经临床病理证实的50例不同发病时期肝脓肿的CT平扫及三期强化特点,并与肝癌、肝转移瘤、肝血管瘤等对照分析。结果按照肝脓肿病变发展阶段不同,其CT表现可分3种。早期肝脓肿(10例,有2种表现形式:小房腔性和团块状肝脓肿),典型肝脓肿(38例)和纤维肉芽肿性肝脓肿(2例)。结论肝脓肿在不同病理演变时期CT平扫表现不同,动态三期强化扫描有助于提高肝脓肿诊断符合率。