卡培他滨治疗肿瘤引起手足综合征的Meta分析

目的对卡培他滨治疗肿瘤引起手足综合征的系统综述,评估卡培他滨引起手足综合征的发生情况。方法根据关键词检索出文献共689篇,纳入21篇文献进行系统评价。结果针对手足综合征,以相对危险度LnRR为效应指标进行系统评价,与对照组相比,不同给药方案的卡培他滨引起手足综合征的风险不同,以RD为分析指标与LnRR得到的结果相同。结论与对照组相比,Meta分析结果显示卡培他滨不同给药方案发生手足综合征的风险不同。     

多汗症患者焦虑抑郁状态及睡眠情况研究

目的 观察多汗症患者的焦虑、抑郁状态及睡眠情况,探讨多汗症与情绪之间的关系,为多汗症的认知及精神/心理治疗提供依据。方法 招募首都医科大学宣武医院皮肤科门诊多汗症患者,根据性别、年龄、学历、工作环境、工作性质等进行分组,应用焦虑抑郁量表(Hospital Anxiety and Depression Scale, HADS)及匹茨堡睡眠质量指数(Pittsburgh Sleep Quality Index, PSQI)量表评估患者焦虑、抑郁情况及睡眠情况。结果 本研究共纳入163例多汗症患者,焦虑症状阳性47人(28.83%),抑郁症状阳性146人(89.57%),睡眠障碍53人(32.52%),HADS焦虑、抑郁评分分别为(6.47±2.89)及(10.29±2.22)分,显著高于国内常模(P<0.05);PSQI评分(6.21±3.16)分,睡眠障碍者焦虑、抑郁评分分别为(8.13±3.49)及(9.51±2.22)分,焦虑症状阳性者PSQI得分高于阴性者(P<0.05);不同性别、年龄、学历、工作性质人群之间比较,焦虑、抑郁及睡眠情况差异无统计学意义(P>0.05),室内工作者PSQI评分较室外工作者高(P<0.05)。结论 多汗症患者存在明显焦虑、抑郁状态,且抑郁状态更为严重;睡眠障碍患者存在焦虑及抑郁状态,且焦虑患者普遍存在睡眠障碍;室内工作者睡眠质量较室外工作者差。     

白族手掌主线分布的研究

目的研究300名正常白族人的手掌主线分布,为人类学、医学、遗传学提供正常参数。方法在知情同意手续下,捺印调查对象的手纹。结果A主线,Ⅲ型占96%、Ⅴ型2.17%、Ⅰ型1.83%;B主线,Ⅴ型93%、Ⅶ型7%;C主线,Ⅴ型44.5%、Ⅶ型40.67%、Ⅸ型11.67%、O型3.16%;D主线,Ⅸ型47%、Ⅶ型46%、Ⅺ型7%。主线分布以3 5′5″7、3 5′7 9、3 5″7 9为主(占76.67%)。39.67%的个体双手主线对称分布,以3 5′5″7为主(15%)。MLI平均为6.25±1.37,MLIT为22.52±3.00,二者均为男性大于女性(P<0.05),无手别差异(P>0.05)。3.17%的个体缺失c三叉。结论白族人的手掌主线和其他民族有共性又有其特异性。     

广西壮族和苗族人扣手、交叉臂、惯用手、环食指长及拇指类型的研究

目的探讨广西壮、苗族人5项人类遗传学经典指标的规律。方法对聚居于广西的1046名壮、苗族学生进行调查。结果(1)广西壮、苗族R型扣手、R型交叉臂和R型惯用手百分率,民族间差异均无显著性(P>0.05):扣手和交叉臂与性别无关;(2)广西壮族环指长和直型拇指类型百分率均高于苗族,差异有显著性或高度显著性(P<0.05或P<0.001);(3)苗族男性环指长百分率高于女性,壮族女性直型拇指类型百分率高于男性(P<0.05)。结论广西壮、苗族人扣手、交手臂、惯用手、环食指长和拇指类型有其规律性。     

Basilic vein aneurysm and palmar intramuscular hemangioma with peri and inter tendinous growth

In this report, we describe a case of concomitant basilic vein aneurysm and palmar hemangioma with peri- and inter-tendinous growth around the fourth and fifth flexor digitorum superficialis and flexor digitorum profundus tendons.It seems reasonable for physicians and radiologists to keep in mind the possibility of venous aneurysms in the presence of soft tissue hemangiomas; as they can present as palpable mass and be mistaken for other pathologies. Familiarity with clinical and imaging findings of this entity could be helpful to prevent misdiagnosis.     

Hyperhidrosis in sleep disorders – A narrative review of mechanisms and clinical significance

Hyperhidrosis is characterized by excessive sweating beyond thermoregulatory needs that affects patients' quality of life. It results from an excessive stimulation of eccrine sweat glands in the skin by the sympathetic nervous system. Hyperhidrosis may be primary or secondary to an underlying cause. Nocturnal hyperhidrosis is associated with different sleep disorders, such as obstructive sleep apnea, insomnia, restless legs syndrome/periodic limb movement during sleep and narcolepsy. The major cause of the hyperhidrosis is sympathetic overactivity and, in the case of narcolepsy type 1, orexin deficiency may also contribute. In this narrative review, we will provide an outline of the possible mechanisms underlying sudomotor dysfunction and the resulting nocturnal hyperhidrosis in these different sleep disorders and explore its clinical relevance.     

Mydriasis and anisocoria in a pediatric hyperhidrosis patient with interesting findings in the family cat

Here, we report a case of unilateral ocular mydriasis in a pediatric patient with longstanding hyperhidrosis, as well as similar findings in her cat. The patient had been undergoing treatment of her hyperhidrosis with topical glycopyrrolate. This case highlights the potential side effect profile of topical antimuscarinics and the importance of counseling patients on proper precautions.