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排序方式: 共有336条查询结果,搜索用时 15 毫秒
61.
62.
目的探讨CK19、CyclinD1、HBME-1、34βE12、TPO、galectin-3在甲状腺乳头状癌(PTC)组织中的表达情况及其临床意义。方法应用免疫组化EnVision法,检测86例PTC、60例甲状腺滤泡性腺瘤(FTA)中CK19、CyclinD1、HBME-1、34βE12、TPO、galectin-3的表达情况。结果CK19和galectin-3表达PTC组织与滤泡性腺瘤比较无明显差异;PTC中CyclinD1、HBME-1、34βE12阳性表达率分别为93.02%、93.02%、90.69%,明显高于滤泡性腺瘤。PTC中TPO表达阳性率为2.33%,滤泡性腺瘤中其表达率为90.00%,两者比较有明显差异(P〈0.01)。结论HBME-1、CyclinD1、34βE12和TPO的联合检测,有助于提高PTC的确诊率,而CK19、galectin-3对鉴别PTC和FTA意义不明确。 相似文献
63.
目的:观察微血管损伤在糖尿病肾病中发病的关键作用。方法:以单侧肾切除并链脲佐菌素尾静脉注射建立糖尿病肾病模型,测定动态观察4、8、12、16、20周肾小管周围毛细血管网(PTC)、血管内膜厚度、肾小球硬化指数、肾小球毛细血管袢、肾小球体积、细胞外基质等指标。结果:随造模时间延长,糖尿病肾病组大鼠肾小球毛细血管袢开放面积减少,肾小球体积增大,肾间质PTC网减少,动脉内膜增厚,肾小球硬化指数、系膜基质增加。与假手术组比较均有统计学意义(P<0.05或P<0.01)。结论:肾间质PTC网与肾小球硬化呈明显负相关,PTC网越少,肾小球毛细血管褂开放面积减少,肾小球硬化更严重;同时PTC网减少导致肾缺血也是肾间质纤维化和肾乳头坏死的原因。 相似文献
64.
65.
Hepatobiliary tuberculosis 总被引:3,自引:0,他引:3
SOL Z ALVAREZ 《Journal of gastroenterology and hepatology》1998,13(8):833-839
Tuberculosis is known to involve the liver in different ways. The term hepatobiliary tuberculosis refers to the localized form of hepatic tuberculosis as a distinct clinical entity, with signs and symptoms related to the hepatobiliary tract. Its clinical features and the different diagnostic aids used in its diagnosis are reviewed. Plain abdominal radiographs showing diffuse hepatic calcifications seen in approximately 50% of cases are almost diagnostic for hepatobiliary tuberculosis. Liver biopsies obtained either by ultrasound, computed tomography or laparoscopy, showing caseating granuloma usually establish the diagnosis. In the absence of caseation necrosis, a positive acid-fast bacillus (AFB) or culture for Mycobacterium tuberculosis is needed to establish the diagnosis. A polymerase chain reaction assay for the identification of Mycobacterium tuberculosis in liver biopsy specimens is a new development. Treatment is similar to that used for pulmonary tuberculosis. Quadruple therapy (using four anti-tuberculosis drugs) is recommended, generally for 1 year. For patients with obstructive jaundice, in addition to anti-tuberculous treatment, biliary decompression should be performed either by stent insertion during endoscopic retrograde cholangiopancreatology, by percutaneous transhepatic biliary drainage or by surgical decompression whenever feasible. 相似文献
66.
67.
68.
Histological analysis of late renal allografts of antidonor antibody positive patients with C4d deposits in peritubular capillaries 总被引:3,自引:0,他引:3
K Aita Y Yamaguchi T Shimizu S Horita M Furusawa K Tanabe S Fuchinoue H Toma 《Clinical transplantation》2004,18(S11):7-12
Abstract: The association of humoral immunity with late renal allograft dysfunction has recently been recognized, and many reports have revealed C4d deposits in peritubular capillaries (C4d in PTC), and the presence of serum antidonor HLA antibody in patients suffering from graft dysfunction, long time after transplantation. In this study, morphological changes in renal allograft biopsies more than 1 year after transplantation in 14 patients with C4d in PTC and serum antidonor antibody were investigated for the presence of chronic rejection (CR). In addition to the light microscope study, an electron microscope study was done to evaluate the multilayering of the peritubular capillary basement membrane (MLPTC). Histologically, only seven of 14 patients met the criteria of CR, and 71.4% (5/7) of CR patients had episodes of acute humoral rejection (AHR), coexisting with acute tubulointerstitial rejection. Peritubular capillaritis was observed in all patients, although it differed in severity. Transplant glomerulitis and interstitial inflammation were also observed in many patients: 71.4% (10/14) and 92.9% (13/14) respectively. MLPTC was observed in 12 patients (85.7%), but the severity of the MLPTC did not reflect the severity of peritubular capillaritis or any other histological features. The long-term outcomes of the patients CR, especially those with episodes of AHR, were poor, and two of them lost their graft functions. On the other hand, patients without CR had relatively favourable outcomes. In conclusion, we confirmed the diverse morphological changes of late renal allografts, which cannot be categorized as chronic humoral rejection (CHR), and such patients who do not have typical morphological changes such as CHR, should be followed-up on a long-term basis in order to clarify the significance of C4d on PTC in late renal allografts. 相似文献
69.
Mary Y. Tadros Amir L. Louka 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(1):4-11
Background
There is no doubt that the role of Different diagnostic imaging is well established in the evaluation of patients who are being evaluated for potential liver transplantation but it plays a huge role in the success of transplanted liver operations. Technical advances in imaging equipment and techniques allow more accurate assessment of postoperative living donor transplantation complications.Objective
To assess the role and importance of different radiological imaging modalities in evaluating and diagnosing recipient complications after living donor liver transplantation.Materials and methods
50 patients who underwent living donor liver transplantation (LDLT) were followed for at least 6?months and submitted for routine investigation including laboratory tests and imaging. The biliary complications were diagnosed with ultrasound (US) but MRCP was more diagnostic over ultrasound in case of location of strictures. Endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous cholangiography (PTC) was used for therapeutic reasons. Stenting was tried in cases of biliary leakage. Doppler US was used in cases of graft rejection. CTA was used in cases whose HA (hepatic artery) couldn’t be detected by Doppler. Conventional angiography was used as a therapeutic tool for restoration of HA patency. This study was held between November 2014 until December 2016.Results
Over 50 patients who underwent living donor liver transplantation. The morbidity rate was 66% (33 patients), where 17 patients passed an uncomplicated course, Biliary tract complications occurred in 13 patients (26%). Vascular complications were found in 8 patients (16%), one had portal vein thrombus and another patient had hepatic artery stenosis and underwent stent. Mild pleural effusion was seen in 30 patients (60%). Moderate to marked pleural effusion was seen in 13 patients (26%), Ascites was considered significant in case of moderate to marked or that persist after two weeks. Six patients complained significant collections, two of them improved by single tapping, whereas two patients required pig tail drainage (7 to14 days).The incidence of rejection was 24% in our study (12 patients) 75% of rejection (nine patients) occurred during the first two months postoperative.One case showed multiple hypodense hepatic focal lesions and the diagnosis was made by histopathology (biopsy) and was lymphoma.Conclusion
The different radiological modalities are a cornerstone in the success of the liver transplantation operation together with curious postoperative follow up are the key for diagnosis of most of the complications including vascular, biliary and collections and even rejection cases. 相似文献70.
目的:探讨乳头状甲状腺癌(papillary thyroid carcinoma,PTC)中脂质代谢相关基因的变化。方法:应用3组新鲜的PTC癌组织及癌旁甲状腺组织,采用RT2 ProfilerTM PCR ARRAY(Qiagen)进行脂质代谢基因的筛选,探讨PTC癌及癌旁甲状腺组织中表达差异较大的基因。采用RT-PCR法在46对PTC癌及癌旁甲状腺组织中对筛选得到的基因表达差异较大的基因进行验证。结果:经过筛选及验证发现,SLC27A6(FATP6)、FABP3在PTC癌组织中的表达高于癌旁甲状腺组织(P<0.05)。结论:PTC癌组织中FATP6及FABP3在mRNA水平上的表达高于癌旁甲状腺组织,上述分子及其参与的脂肪酸代谢可能成为PTC诊治的新靶点。 相似文献