绝经后阴道出血96例临床分析

目的:分析绝经后阴道出血的病因并探讨其对策。方法:对96例绝经后阴道出血患者的临床资料进行回顾性分析。结果:恶性肿瘤占17.70%(17例),绝经年限越长,恶性肿瘤所占的比例越大。结论:绝经后阴道出血患者的年龄和绝经年限与恶性肿瘤发生率间有较明显的正相关关系,因此绝经后阴道出血可视为一种危险信号,更要提高警惕,采取必要的检查手段,积极治疗良性疾病,预防发生恶性肿瘤,做到早期发现,早期治疗。     

细小病毒H—1对正常仓鼠肝肾脏器功能及形态的实验研究

目的探讨细小病毒H-1对成年仓鼠肝肾脏器的影响.方法采用正常成年金黄仓鼠腹腔内注射细小病毒H-1(5×106pfu、1×108pfu两组),动态观察动物血清肝肾功能及病理形态变化.结果反映肝功能的血清学指标如SGPT和SCOT、反映肾功能的指标如BUN和肌肝(Cr)在实验动物组与对照动物组之间无显著性差异(P＞0.05).病理组织学及超微结构观察发现动物在接种PVH-1的当天、3d及7d时,肝脏组织学无明显变化,第14d极小部分肝脏呈现轻度炎症表现;可见散在分布的少数肝细胞气球样变性、点状坏死.电镜下可见少数肝细胞胞浆疏松、线粒体肿胀.但是在接种后第30d及第90d肝脏组织学已无明显炎症性变化.电镜下可见肾小球结构清晰、系膜细胞形态正常.结论本实验证实细小病毒H-1对成年健康仓鼠肝细胞有一过性、轻微损伤,对肾脏无明显不良反应.     

侧脑室-腹腔分流术治疗正常压力脑积水28例

目的 探讨正常压力脑积水的手术治疗。方法 采用中、低压分流管行侧脑室-腹腔分流术。结果 本组28例，术后均得到6个月～3年随访，18例患者恢复正常生活，8例患者生活自理，2例患者术后症状无明显改善。结论 侧脑室-腹腔分流术是治疗正常压力脑积水最有效的方法。     

单胺氧化酶与胚胎植入关系的研究进展

单胺氧化酶是一种参与胺类物质代谢的酶,其底物主要包括5-羟色胺、肾上腺素和去甲肾上腺素等生物活性胺。单胺氧化酶通过对其底物的代谢发挥生理作用,主要参与神经活动调节。然而在对胚胎植入和子宫内膜容受形成的研究中发现,在人子宫内膜容受窗期其亚型之一单胺氧化酶A表达明显上调,提示单胺氧化酶与胚胎植入有密切关系。随研究深入,越来越多的研究证实单胺氧化酶参与胚胎着床的调控,但其具体作用及作用机制目前还不清楚。综述有关单胺氧化酶与胚胎植入的相关研究。     

325例子宫内膜诊刮临床病理分析

目的 通过对诊刮的子宫内膜作临床病理分析，讨论内膜诊刮的病因及病理检查的临床意义，方法 复习３２５例３０岁以上内膜诊刮病理切片，观察各年龄组与内膜病变的特点，并根据诊刮原因分析各组与病理诊断结果的关系。结果 临床诊刮以不规则阴道出血为多，大部分为功能失调内膜，良性增生性疾病各年龄组相比较无显著性差异（Ｐ〉０．０５），而恶性肿瘤在６０岁以上与６０岁以下两者相比发生率明显升高（Ｐ〈０．００１）。育龄期     

卵巢对促性腺激素的反应性与内膜对胚胎容受性

胚胎的种植是一个复杂的程序化过程,需要胚胎与子宫内膜发育协调一致才能够顺利完成.超排卵方案在体外受精-胚胎移植(IVF-ET)中的应用增加了获卵数目,便于获得优质胚胎,以保证临床妊娠率.但仅有优质胚胎是不够的,要达成临床妊娠,另一个关键的制约因素是子宫内膜的容受性.     

正常阑尾的16层螺旋CT表现

目的:应用16层螺旋CT多方位(MPR)重建技术,分析评估正常阑尾在多层螺旋CT的显示率及其形态表现。材料和方法:随机选择89例无阑尾手术史,因为腹部病变等而行16层螺旋CT平扫的患者作回顾性正常阑尾分析。在AW4.1工作站采用层厚1.25mm作多方位图像重建。结果:89例患者,CT图像显示阑尾84例。正常阑尾显示的敏感性为94%。正常阑尾平均直径为(5.5±1.1)mm(3-10mm),直径超过6mm者为16例,占19%。结论:应用多层螺旋CT平扫,利用多方位重建,可满意地显示大部分阑尾的全貌。正常阑尾的直径为3-10mm,因此将阑尾直径≥6mm作为诊断阑尾炎的标准时,必须结合阑尾炎的其他CT征象,否则可能会出现假阳性结果。     

弱智儿童Stroop效应实验研究

目的探讨弱智儿童色一词干扰效应现象，智力落后是否影响Stroop效应。方法用于实验走三套板块，每套板块含四块纸板。第一套板块（称属A条件），用于封颜色读名实验；第二套板块（称为B条件），用于封黑字读名实验；第三套板块（称为C条件），用于读用不同颜色写的但与颜色相矛盾的字读名实验。被试按实验要求，依次进行A、B、C条件实验。主试用记时器记绿被试在不同实验条件下的读名时间及误差次数．结果读字名比封读色名速度快。Stroop效应（C条件）现象，在弱智儿童中表现得比正常儿童更为强烈，结论智商低下会出现更明显Stroop效应。     

The relation between coronary flow rate, plasma endothelin-1 concentrations, and clinical characteristics in patients with normal coronary arteries

BACKGROUND: Coronary slow flow (CSF) is characterized by delayed opacification of epicardial arteries in the absence of occlusive disease. In the present study, we aimed to investigate the relation between coronary flow rate, plasma endothelin-1 (ET-1) concentrations, and clinical characteristics in patients with normal coronary arteries. METHODS: The study population included 77 patients with angiographically normal coronary arteries who underwent coronary angiography on suspicion of ischemic heart disease due to typical chest pain or ischemic findings on treadmill exercise test or myocardial scintigraphy. Based on the Thrombolysis In Myocardial Infarction frame count (TFC), patients were grouped into those with normal coronary flow and those with slow coronary flow. RESULTS: Forty-eight (61.5%) patients were found to have CSF. Plasma ET-1 concentrations were significantly higher with the presence of CSF (P=.03). There were significant differences between plasma ET-1 concentrations, and mean TFC, TFC for left anterior descending coronary artery (LAD), TFC for left circumflex coronary artery (CX), and TFC for right coronary artery separately in patients with and without CSF (P=.033, P<.001, P<.001, P<.001, and P<.001, respectively). Mean TFC, TFC for LAD, and TFC for CX, and ET-1 concentrations were significantly higher in smokers than in nonsmokers (P<.001, P<.001, P=.004, and P=.033, respectively). However, logistic regression analysis suggested that ET-1 concentration was not an independent determinant of CSF. CONCLUSIONS: Although there is a significant relation between ET-1 concentrations and coronary flow rate, ET-1 concentrations are not sufficient to determine the presence of CSF. Smoking is strongly associated with CSF, TFC, and increased ET-1 concentrations.     

Binding of ovine uterine serpin to lymphocytes.

PROBLEM: The endometrium of the sheep produces a progesterone-induced member of the serpin superfamily of serine proteinase inhibitors that can inhibit lymphocyte proliferation and reduce natural killer cell activity. Present results indicate that this molecule, called ovine uterine serpin (OvUS), can bind specifically to lymphocytes. METHOD OF STUDY/RESULTS: Biotinylated OvUS bound to peripheral blood lymphocytes in a dose-dependent and saturable manner. Binding was inhibited by OvUS, but not by several other proteins, including serpin-enzyme complex (alpha 1-antitrypsin-trypsin). Heparin blocked binding when added to the binding reaction or when used to pretreat lymphocytes. Both lymphocytes and Madin-Darby bovine kidney (MDBK) cells also bound fluorescein isothiocyanate-labeled OvUS. CONCLUSIONS: Results suggest that OvUS can interact with lymphocytes and other cells through binding to a cell surface molecule. Such binding may indicate that inhibition of lymphocyte activation by OvUS involves 1) binding of OvUS to a cell surface receptor or 2) competitive inhibition of binding between OvUS and a co-activation molecule required for lymphocyte activation.