国产美满霉素、阿齐霉素、克拉霉素治疗非淋菌性泌尿生殖道炎疗效观察

目的 为观察国产美满霉素、阿齐霉素、克拉霉素治疗NGU疗效。方法 使用国产美满霉素、阿齐霉素、克拉霉素治疗并观察272例NGU患者。结果 阿齐霉素、克拉霉素和美满霉素治愈率分别为74.58％、78.12％和51.72％。结论 阿齐霉素、克拉霉素治疗NGU效果优于美满霉素,且副作用较小,是目前治疗NGU的较好药物。     

小鼠生殖道解脲支原体感染动物模型的建立与形态学研究

目的:建立小鼠生殖道解脲支原体感染的动物模型,为进一步研究中医药抗支原体感染的疗效机制提供动物模型。方法:BALB/C小鼠46只,随机分为4组。采用注射外源性雌激素(苯甲酸雌二醇),阴道接种解脲支原体标准菌株的方法,建立小鼠生殖道解脲支原体感染的模型。结果:给支原体菌液浓度为2.5×105ccu/mL的小鼠全部感染成功。感染后小鼠有生殖道支原体感染的症状表现。组织病理学检查提示解脲支原体感染可逆行波及上生殖道器官。结论:通过组织形态学观察证明UU具有致病性,可造成生殖道炎症改变,并成功建立了解脲支原体感染雌性小鼠致生殖道炎症的模型。     

UAA-AAUS guideline for M. genitalium and non-chlamydial non-gonococcal urethritis

Non-chlamydial non-gonococcal urethritis (NCNGU) is defined as urethritis with neither Neisseria gonorrhoeae nor Chlamydia trachomatis. Possible causative agents of NCNGU include Mycoplasma genitalium, Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis, Trichomonas vaginalis, and so on. Among these microorganisms, the pathogenicity of M. genitalium and T. vaginalis to the male urethra has been confirmed so far.The Asian Association of Urinary Tract Infection and Sexually Transmitted Infection (AAUS) belonging to the Urological Association of Asia (UAA) had developed the guidelines regarding NCNGU and the present guidelines were updated from previous edition. Relevant references were meticulously reviewed again and latest studies were collected. In addition to the levels of evidence, the recommendation grades were defined using the modified GRADE methodology. Herein, we present the new edition of the UAA-AAUS guidelines for M. genitalium and non-chlamydial non-gonococcal urethritis.     

1995-2005年海岛地区性病疫情分析

目的 分析浙江省玉环县1995-2005年11年性传播疾病(STD)的流行趋势及特点,为制定有效的防治策略提供依据.方法 对玉环县11年8种法定报告STD监测资料进行统计分析.结果 11年8种监测STD中,除性病性淋病肉芽肿外,其余7种均有报告,累计报告STD 8479例,年平均发病率197.47/10万,年平均增长率为12.68%.结论 玉环县STD发病呈增长趋势,其中梅毒和非淋球菌性尿道炎(NGU)的增长较为显著,加强STD防治知识的普及,提倡安全性行为,是控制STD蔓延的有效措施.     

An Unusual Cause of Pelvic Pain and Fever: Periurethral Abscess from an Infected Urethral Diverticulum

Background

The evaluation of patients with pelvic pain is a common task for emergency physicians. Accurate diagnosis of the underlying cause of pelvic pain in women is often difficult given the diversity of pathology that can generate pelvic pain.

Objective

To report a rare but clinically significant cause of acute pelvic pain in women.

Case Report

We describe a rare case of a periurethral abscess secondary to an infected urethral diverticulum in a 41-year-old woman. She presented to our Emergency Department with pelvic pain, dysuria, and fever of 4 days duration.

Conclusion

Physical examination, imaging studies, and surgery aided in confirming the diagnosis of a periurethral abscess.     

5种治疗淋菌性尿道炎方法的成本-效果分析

目的 :探讨不同药物治疗方法对相同疾病的经济效果。方法 :选择146例淋菌性尿道炎病人 ,用5种不同的药物治疗 ,分别为A组阿奇霉素 ,B组克拉霉素 ,C组头孢克洛 ,D组头孢曲松和E组大观霉毒 ;A、B、C3组均为口服给药 ,疗程7d ;D、E组为肌肉注射给药 ,疗程3d。运用药物经济学的成本 -效果分析方法进行评价。结果 :5种方法的总成本依次为297 70、219 88、134 81、501 55、265 57元 ,其有效率分别为95 4 %、91 7 %、100 %、100 %、98 1 %。结论 :C组方法为最佳治疗方案。     

复发性NGU患者及UU／Mh正常携带者焦虑抑郁情绪调查分析

目的了解复发性尿道（阴道）炎（NGU）患者及正常携带焦虑抑郁情绪的发生情况。方法以200例慢性NGU患者为试验A组，以200例同期就诊的UU／Mh正常携带者为试验B组。采用焦虑自评量表（SAS）和抑郁自评量表（SDS）分别对两组进行测评分析，测量病人的焦虑值50分以上为焦虑状态，测量病人的抑郁值》53分以上为抑郁状态。结果①试验A组焦虑情绪发生率为55．5％（111／200），试验B组焦虑情绪发生率为54．5％（109／200）；②用SDS量表测定试验A组的抑郁绪发生率为53．5％（107／200），试验B组抑郁情绪的发生率为50．5％（101／200）。结论复发性NGU患者及UU／Mh正常携带者都存在着明显的心理差异，焦虑和抑郁情绪的表现都很突出。在诊疗过程中既要对患者进行有效的药物治疗，又应积极发现其焦虑抑郁情绪等心理症状，加强相应的心理治疗。特别是针对UU／Mh正常携带者，临床医生对其下性病的诊断的时候要慎重，以免给患者造成不必要的心理疾病。     

司帕沙星治疗非淋球菌性尿道炎66例

目的：评价司帕沙星对非淋球菌性尿道炎中支原体、衣原体感染的疗效。方法：６６例非淋球菌性尿道炎病人中支原体感染５１例,衣原体感染１５例（男性３９例,女性２７例;年龄３２ａ±ｓ９ａ）。用司帕沙星２００ｍｇ,ｐｏ,ｑｎ×６ｄ。结果：对支原体感染有效率为９１％,痊愈率为６９％。衣原体感染有效率为９３％,痊愈率为７３％。３６例病人的血药浓度在０．３９～１．８ｍｇ／Ｌ之间。结论：司帕沙星治疗支原体、衣原体感染疗效好、不良反应少、服用方便。     

非淋菌性尿道炎(NGU)患者的支原体培养及药敏试验

目的了解NGU的支原体培养及其药敏试验结果。方法采用法国梅里埃(BioMerieux)MycoplasmaIST(支原体鉴定药敏)试剂盒进行操作。结果解脲脲原体(Uu)及人型支原体(Mh)阳性率分别为25.9%、13.1%。混合感染6.4%。药敏以红霉素耐药率最高(93.6%),其次为氧氟沙星(69.3%)。其它抗生素亦有不同程度的耐药。结论1.Uu,Mh平衡培养有利于提高检测阳性率2.合理使用抗生素应参考药敏结果。     

Novel multiplex real-time PCR system using the SNP technology for the simultaneous diagnosis of Chlamydia trachomatis, Ureaplasma parvum and Ureaplasma urealyticum and genetic typing of serovars of C. trachomatis and U. parvum in NGU

To explore the possibilities of a novel multiplex real-time PCR system for rapid diagnosis, genetic typing of serovars and clinical application in NGU, we developed a multiplex real-time PCR system for the simultaneous diagnosis of Chlamydia trachomatis, Ureaplasma parvum and Ureaplasma urealyticum and molecular detection of serovars of C. trachomatis and U. parvum in NGU using the SNP technology and TaqMan-LNA probe. In 57 pathogen-positive clinical specimens, we identified the following C. trachomatis serovars: D (20.05%, 12/57), E (36.84%, 21/57), F (19.30%, 11/57), G (8.77%, 5/57), H (5.26%, 3/57), J (3.51%, 2/57), and K (5.26%, 3/57). In 115 pathogen-positive clinical specimens, we identified the following U. parvum serovars: 1 (0.87%, 2/115), 3 (55.65%, 64/115), 6 (20.87%, 24/115) and 14 (21.74%, 25/115). Our fast pathogen diagnosis and serotyping assay using real-time TaqMan-LNA PCR may improve our ability to study the pathogenesis and epidemiology of NGU.