中西医结合治疗支气管哮喘46例疗效观察

目的:观察中西医结合治疗支气管哮喘的临床疗效。方法:将92例患者随机分成治疗组与对照组各46例,2组均静滴抗生素,同时静滴氨茶碱,治疗组加服自拟祛痰平喘汤。结果:2组治疗2周后,治疗组治愈率为76.09%,对照组为47.83%。治疗组在平喘及减少复发次数方面优于对照组。2组比较,差异有显著性意义(p<0.05)。结论:中西医结合治疗本病能迅速改善症状,缩短病程,减少副作用发生,提高临床疗效。     

《伤寒论》对多脏器功能障碍综合征治疗的启示

《伤寒论》以六经为纲,以证候为目,不仅叙述了外感伤寒热病的六经传变发病过程,也充分揭示了机体多系统疾病的发生、发展与结局的内在机制。认为伤寒热病的急性发病规律与六经中不同的传变机制,和现代医学多脏器功能障碍综合征(MODS)相似。其中的急下证、蓄血证、蓄血发黄证等,均与MODS不同的器官损伤密切相关。深入研究《伤寒论》辨治规律与MODS的相关性,对于拓宽MODS的临床治疗途径,具有重要意义。     

辨证掌握穴位注射方法提高穴位注射的疗效

目的:提高中西结合治疗疾病的疗效.方法:在中医辨证的基础上,在腧穴上进行针剂注射.结果:通过针刺和药液渗透,将穴位疗效和药理作用结合在一起,充分发挥其综合效能.结论:用中医辨证理论,穴位注射治疗能疏通经络,调补阴阳.针药结合,提高疗效.     

Calreticulin binding and other biological activities of survival peptide Y-P30 including effects of systemic treatment of rats

Neuron survival-promoting peptide Y-P30, purified from oxidatively stressed neural cell lines, inhibits the appearance of microglia and rescues neurons 1 week after direct application to lesions of the rat cerebral cortex (7). Y-P30 affinity matrices treated with solubilized membranes from a variety of cell lines including human neuroblastoma SY5Y, mouse hippocampal cells HN 33.1, and human promonocytes HL-60, as well as with cerebral cortex tissue from both humans and rats, showed highly specific binding to calreticulin, a ubiquitous calcium binding protein that may be critical for integrin function. Treatment of cultures with 0.1 nM Y-P30 stabilized all these cell types whether differentiated or not, while 1 microM peptide also inhibited the morphological differentiation of the HL-60 cells into macrophages. Western analysis of the medium of SY5Y cell cultures suggested Y-P30-stimulated release of calreticulin, a result consistent with its other biological activities. Likewise, single dose systemic application of Y-P30 in unoperated rats and in rats with cerebral cortex lesions produced significant reductions in cerebral cortex membrane-associated calreticulin. Both direct and intravenous treatment with peptide also reduced cortical neuron atrophy 4 days after these lesions but only direct application consistently inhibited the appearance of ED-1(+) monocyte derivatives. We suggest that in vitro and in vivo mechanisms of Y-P30 effects are similar and involve the targeting of calreticulin. The results also suggest that some of these activities are apparent in the cerebral cortex after systemic application of this peptide.     

Effects of sub-chronic combined treatment with pergolide and caffeine on contralateral rotational behavior in unilateral 6-hydroxydopamine-denervated rats

We studied the synergistic effects of pergolide and bromocriptine with caffeine on turning behavior in 6-OHDA denervated rats. Both pergolide and bromocriptine were synergistic with caffeine, and prevented tolerance to caffeine-induced turning. When caffeine was removed, tolerance to bromocriptine effects was observed for 1 day only, while no tolerance was observed to pergolide. These results suggest that caffeine could be useful in the treatment of Parkinson's disease, preferentially as an adjuvant of mixed dopaminergic agonists like pergolide.     

Chronic cocaine treatment induces dysregulation in the circadian pattern of rats' feeding behavior

The effects of protracted cocaine administration (15 mg/kg i.p., twice a day for 9 days) on the circadian pattern of feeding behavior was studied in individually housed male Sprague-Dawley rats, maintained under a 12:12 light:dark cycle. Water and food were available ad libitum and food intake was measured twice a day before, during and after withdrawal of cocaine (or saline) treatment. Neither total 24-h food intake, nor body mass at the end of the experiment, was significantly different between cocaine-treated and control animals. However, cocaine administration affected the temporal distribution of food consumption. During the dark (activity) phase, rats receiving cocaine injections consumed significantly less food than control animals, and this effect persisted for up to 3 days of cocaine withdrawal. During the light (rest) phase, cocaine administration promoted food consumption and a significantly higher food intake was also observed during the first five cocaine withdrawal days. Continuous monitoring of locomotor activity did not reveal significant changes in the circadian pattern of activity between the two experimental groups during different treatment periods, except for an acute increase in locomotion within an hour after daytime cocaine injection. The results of this study demonstrate that sub-chronic cocaine administration alters the circadian pattern of rats' feeding behavior.     

水处理各环节对血液透析用水质量的影响分析

目的 研究水处理各环节对血液透析用水质量的影响。方法 2003年对湖南地区99家透析中心水处理方式、各部件更换消毒情况以及反渗水生物学及理化特征进行卫生学调查和测定。结果 前处理填料及反渗膜更换时间、消毒间隔时间以及反渗水输送模式对反渗水生物学特性及理化特性均有影响。结论 定期做好水处理消毒及填料更换以及采用闭路循环输送反渗水是保证透析用水水质合格的关键所在。     

治疗免疫性血小板减少症的研究与展望（综述）

目的:对近十年来免疫性血小板减少症的各种疗法进行综述.方法:查阅文献.结果:治疗主要方法有大剂量 IgG,皮 质内固醇,免疫抑制剂,脾切除,中医药等.结论:抗体破坏血小板是血小板减少症的常见原因.     

急性冠状动脉综合症药物治疗（综述）

目的:对急性冠状动脉综合征的治疗进展作一综述.方法:查阅近2～3年国内外最新研究进展进行分析、汇总.结果:近年来,急性冠状动脉综合征的介入治疗一直是一个有争议的课题.一种是保守策略,另一种是早期有创干预策略.近期临床研究一致显示,对中、高危的急性冠状动脉综合征患者宜实行早期有创干预策略.结论:对急性冠状动脉综合征患者宜进行早期诊断,及时危险分层和合理的临床干预.     

成人生长激素缺乏症诊治进展（综述）

介绍成人生长激素缺乏症诊断与治疗方面的一些进展,强调动态试验对于诊断的作用及注意事项,与替代治疗相关的问题涉及剂量、疗程、对代谢的影响及治疗的安全性等.