全文获取类型
收费全文 | 226458篇 |
免费 | 18065篇 |
国内免费 | 7245篇 |
专业分类
耳鼻咽喉 | 1268篇 |
儿科学 | 7867篇 |
妇产科学 | 1640篇 |
基础医学 | 19942篇 |
口腔科学 | 3688篇 |
临床医学 | 23652篇 |
内科学 | 56616篇 |
皮肤病学 | 2743篇 |
神经病学 | 26537篇 |
特种医学 | 6521篇 |
外国民族医学 | 4篇 |
外科学 | 17280篇 |
综合类 | 30574篇 |
现状与发展 | 32篇 |
一般理论 | 9篇 |
预防医学 | 20507篇 |
眼科学 | 2417篇 |
药学 | 15740篇 |
192篇 | |
中国医学 | 10693篇 |
肿瘤学 | 3846篇 |
出版年
2024年 | 676篇 |
2023年 | 4769篇 |
2022年 | 8665篇 |
2021年 | 12198篇 |
2020年 | 11469篇 |
2019年 | 8619篇 |
2018年 | 8567篇 |
2017年 | 8464篇 |
2016年 | 8874篇 |
2015年 | 8556篇 |
2014年 | 15987篇 |
2013年 | 17521篇 |
2012年 | 13020篇 |
2011年 | 14224篇 |
2010年 | 11099篇 |
2009年 | 10661篇 |
2008年 | 10644篇 |
2007年 | 10293篇 |
2006年 | 9166篇 |
2005年 | 7584篇 |
2004年 | 6431篇 |
2003年 | 5526篇 |
2002年 | 4660篇 |
2001年 | 4020篇 |
2000年 | 3366篇 |
1999年 | 2885篇 |
1998年 | 2754篇 |
1997年 | 2428篇 |
1996年 | 2181篇 |
1995年 | 1976篇 |
1994年 | 1857篇 |
1993年 | 1599篇 |
1992年 | 1513篇 |
1991年 | 1327篇 |
1990年 | 1058篇 |
1989年 | 891篇 |
1988年 | 842篇 |
1987年 | 765篇 |
1986年 | 647篇 |
1985年 | 767篇 |
1984年 | 649篇 |
1983年 | 395篇 |
1982年 | 462篇 |
1981年 | 392篇 |
1980年 | 298篇 |
1979年 | 259篇 |
1978年 | 199篇 |
1977年 | 171篇 |
1976年 | 139篇 |
1975年 | 56篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Robert F Bonvini Ulrich Sigwart Vitali Verin 《Catheterization and cardiovascular interventions》2007,69(2):274-276
We report the case of a 36-year-old woman admitted for cryptogenic stroke, in whom the Patent Foramen Ovale (PFO) diameter measurement, with a purpose built sizing balloon, performed before the closure procedure, was complicated with the rupture of the inter-atrial septum generating an Atrial Septal Defect (ASD) with a significant left-to-right shunt. This kind of complication may not be easy to handle, changing the initial procedural strategy from PFO to ASD closure technique requiring specific material and operator's technical skill. 相似文献
992.
993.
扎拥 《解放军保健医学杂志》2009,(3):216-218
目的探讨西藏拉萨地区幽门螺杆菌(Helicobacter pyloric,Hp)感染与冠心病及多种危险因素的关系。为该地区冠心病的防治提供依据。方法分为冠心病组46例和非冠心病组51例,应用检测血抗HpIgG及-C-尿素呼气试验方法检测Hp感染情况,并分别测定各组血脂、血糖、餐后2h血糖、C反应蛋白、纤维蛋白原、白细胞总数。结果冠心病组患者血清抗HpIgG阳性率为50.0%(23/46),明显高于非冠心病组的23.5%(12/51),P〈0.05;冠心病患者Hp现症感染率为54.3%(25/46),明显高于非冠心病组的31.3%(27/51),P〈0.05;冠心病组Hp感染患者血脂、空腹及餐后2h血糖、C反应蛋白、纤维蛋白原较非感染患者明显升高(P〈0.05)。结论Hp感染与冠心病相关,可能是拉萨地区冠心病发病的独立危险因素。 相似文献
994.
S. Doğru-Abbasoğlu G. Aykaç-Toker H. A. Hanagasi H. Gürvit M. Emre M. Uysal 《Neurological sciences》2007,28(1):31-34
Abstract Alzheimer's disease (AD) is defined pathologically by the presence of β-amyloid plaques, neurofibrillary tangles and extensive
neuronal loss. Evidence indicates that increased DNA damage may contribute to neuronal loss in AD. Recently, it has been shown
that in AD neurons have a reduced capacity for some types of DNA repair. Polymorphisms in DNA repair genes may be associated
with differences in repair efficiency of DNA damage. Variants of several DNA repair genes, including the base excision repair
gene XRCC1, have been described previously. We hypothesised that Arg194Trp polymorphism of XRCC1 gene may contribute to genetic susceptibility for AD. In order to test this hypothesis, we investigated
Arg194Trp polymorphism at the XRCC1 gene in the DNA samples of 98 patients with AD and 95 healthy subjects. The frequency of the Trp allele was more pronounced among cases (11.2%) compared with controls (5.8%). On combining the homozygous and heterozygous
variants of each codon, the variants seemed to be at twofold risk of AD, although the risk estimates were not statistically
significant (OR=1.95, 95% CI 0.88–4.34, p=0.09). In addition, the 194Trp allele revealed a borderline significance (OR=2.05, 95% CI 0.96–4.37, p=0.056). According to our results, it may be speculated that the polymorphic variants of XRCC1 codon 194 have a role in the
development of AD. 相似文献
995.
F. Mattner D. Sohr A. Heim P. Gastmeier H. Vennema M. Koopmans 《Clinical microbiology and infection》2006,12(1):69-74
Norovirus infections have been described as self-limiting diseases of short duration. An investigation of a norovirus outbreak in a university hospital provided evidence for severe clinical features in patients with several underlying diseases. Clinical outcomes of norovirus infection were defined. Risk-factor analysis targeting underlying diseases and medication was performed using multivariate analyses. In five outbreak wards, 84 patients and 60 nurses were infected (an overall attack rate of 32% in patients, and 76% in nurses). The causative agent was the new variant Grimsby virus. Severe clinical features, including acute renal failure, arrhythmia and signs of acute graft organ rejection in renal transplant patients, were observed in seven (8.3%) patients. In multivariate analyses, cardiovascular disease (OR 17.1, 95% CI 2.17-403) and renal transplant (OR 13.0, 95% CI 1.63-281) were risk-factors for a potassium decrease of >20%. Age >65 years (OR 11.6, 95% CI 1.89-224) was a risk-factor for diarrhoea lasting >2 days. Immunosuppression (OR 5.7, 95% CI 1.78-20.1) was a risk-factor for a creatinine increase of >10%. Norovirus infections in patients with underlying conditions such as cardiovascular disease, renal transplant and immunosuppressive therapy may lead to severe consequences typified by decreased potassium levels, increased levels of C-reactive protein and creatine phosphokinase. In the elderly, norovirus infection may lead to an increased duration of diarrhoea. Therefore patients at risk should be hospitalised early and monitored frequently. Strict preventional measures should be implemented as early as possible to minimise the risk of nosocomial outbreaks. 相似文献
996.
目的 了解衡阳地区性传播疾病(STD)患者病原体感染情况。方法 对2420例可疑STD患者进行检测:淋病奈瑟菌(NG)、解脲脲原体(UU)、人型支原体(MH)采用培养法;沙眼衣原体(CT)、人乳头瘤病毒(HPV)、单纯疱疹病毒(HSV)核酸采用聚合酶链反应(PCR)法;梅毒螺旋体(TP)采用快速血浆反应素环状卡片试验(RPR)和TP-PA法。结果 STD病原体阳性检出率为38.1%(922/2420)。在922例中UU占29.6%,CT20.8%,HPV17.8%,NG17.4%,MH6.3%,HSV4.2%,TP3.9%。结论 衡阳地区STD患者中UU感染率最高,CT和HPV次之,TP感染率最低。 相似文献
997.
998.
R啨sum啨 Objectif D啨tecterparcytom啨triedefluxler啨sidumorbideminimal(RMM)chezlesenfantsatteintsdeB LLAet啨valuersasignificationclinique . M啨thodes 5 8enfantsatte 相似文献
999.
目的 观察应用胫骨横向骨搬移法对犬下肢缺血性疾病动物模型的血管再生效果。方法 将 2 0只犬制成下肢缺血性疾病动物模型 ,建模后 1周对犬的后肢施行胫骨横向骨搬移术 ,即在胫骨内侧嵴开一个 5cm× 1cm骨窗 ,以特制的支架每天 1mm速度向外牵拉。分别于不同时期处死动物 ,通过皮温测定 ,光镜下测量血管密度 ,血管造影等方法来观察血管再生情况。结果 在不同时相点观察到伴随着骨的搬移 ,有明显的毛细血管再生现象 (以第 7~ 2 1天为著 )。结论 应用胫骨横向骨搬移法可对犬下肢缺血性疾病动物模型产生明显的血管再生 ,有明显的治疗效果 相似文献
1000.
目的探讨血清中氨基酸的含量变化与短暂性脑缺血和脑梗死体积大小的关系以及对急性缺血性脑血管病的超早期诊断的意义。方法选择发病6h以内的急性缺血性脑血管病(AICVD)患者80例,其中脑梗死(CI)组57例,短暂性脑缺血(TIA)组23例,CI组中大体积梗死19例,中体积梗死22例,小体积梗死16例,各取血清进行高效液相色谱法分析测定血清Glu和GABA。结果TIA组的超早期血清中L-Glu、GABA含量高于对照组,低于CI组;CI组超早期血清中L-Glu、GABA含量高于对照组和TIA组;超早期梗死灶体积大小与血清中L-Glu、GABA含量呈正相关,含量越高,梗死灶体积越大。结论患者血清中L-Glu、GABA含量高低,对急性缺血性脑血管病的超早期诊断有一定的临床价值。 相似文献