恒定强磁场联合平阳霉素对口腔颌面部癌细胞体外培养的影响

采用噻唑兰（ＭＴＴ）方法观察０．２５Ｔ的恒定强磁场对４种口腔颌面部癌细胞体外培养的影响。发现磁场对这４种癌细胞均有不同程度的抑制作用，其中腺癌细胞比鳞癌细胞对磁场更为敏感，并且随着磁场作用时间加长，这种抑制作用更明显。平阳霉素对体外培养的人粘液表皮样癌ＭＥＣ－１系细胞生长有较强的抑制作用，而与０．２５Ｔ恒定强磁场联合应用后，抑制作用明显增强，两者有相加作用。     

鼻咽癌CT和MRI检查比较研究

本文对比研究了14例经病理证实鼻咽癌的CT和MRI表现，发现CT对观察骨质破坏方面优于MRI检查，MRI在确定咽后壁、顶壁、颅内侵犯和咽后外组淋巴结转移方面优于CT检查，文内提出了CT检查对上述诸方面诊断意见和检查方法选择。     

Impact of cancer patients’ quality of life on that of spouse caregivers

Goals of work This study aimed to examine the correlation between quality of life (QOL) in cancer patients and that of their spouse caregivers and to identify factors that influence this correlation.Patients and methods This cross-sectional study collected data from 121 cancer patient/spouse caregiver dyads. The Functional Assessment of Cancer Therapy Scale-General (FACT-G) was used to measure patients QOL, and the Caregiver Quality of Life Index (CQLI) was used to measure spouse caregivers QOL. Correlation coefficients between patients and caregivers QOL were computed for four dimensions of QOL, as well as a total score for QOL. Correlations between patients and caregivers total QOL scores were furthered analyzed by three groups of factors: disease-/treatment-related, caregiving-related, and relationship-related variables.Main results Only the social/family and functional dimensions of patient QOL and total score for patient QOL were associated with each dimension of their caregivers QOL and with the total score (r=0.27–0.44). Physical and emotional dimensions of patients QOL did not significantly influence spouse caregivers QOL for any dimension nor for the total score. Factors influencing the association between patients and caregivers overall QOL included cancer diagnosis, length of hospitalization, caregiving intensity and duration, marital satisfaction, and caregiving self-esteem.Conclusions Social and functional aspects of patients QOL play a significant role in determining the QOL of their spouse caregivers. The strength of association between patients and spouse caregivers overall QOL can be moderated by some factors.     

鼻咽癌患者淋巴细胞近端着丝粒染色体随体联合频率的分析

本文对60例鼻咽癌患者用银染及非银染方法比较分析了近端着丝粒染色体随体联合的频率(SAs及Ag-AA),发现每细胞平均出现的SAs及Ag-AA分别为0.55和1.29(P<0.01)。D、G组染色体在随体联合中的比例分别为DSAf0.620及0.597,GSAf为0.380及0.403,具有随机性。G显带证实13、14、21号染色体更多地参与随体联合。     

揿针疗法联合常规医护措施治疗癌性疼痛临床研究

目的:观察在常规止痛和护理措施基础上加予揿针刺激耳穴治疗癌性疼痛的临床疗效。方法:将120例轻、中度癌性疼痛患者随机分为对照组和观察组各60例。2组轻度、中度疼痛患者分别口服布洛芬缓释胶囊、盐酸曲马多缓释片口服,并给予综合护理措施,观察组加予揿针刺激耳穴治疗,2组均连续治疗10 d。比较治疗前、治疗10 d后的疼痛视觉模拟评分法(VAS)评分、抑郁自评量表(SDS)评分、焦虑自评量表(SAS)评分,以全面疼痛评估量表评价治疗前后疼痛对日常活动、情绪、睡眠、步行能力、正常工作、与他人之间的关系、生活享受7个方面的影响。比较2组的疼痛缓解率。结果:治疗后,观察组疼痛缓解率为83.33%,高于对照组的65.00%,差异有统计学意义(P<0.05)。2组VAS、SDS及SAS评分均较治疗前下降(P<0.01),观察组3项评分均低于对照组(P<0.01)。2组日常活动、情绪、睡眠、步行能力、正常工作、与他人之间的关系及生活享受评分均较治疗前下降(P<0.01),观察组7项评分均低于对照组(P<0.01)。结论:在现代医学常规止痛和护理措施的基础上加用揿针刺激耳穴干预癌性疼痛患者,可进一步减轻癌痛,缓解患者的抑郁和焦虑,减轻癌痛对日常生活的影响,提高临床疗效。     

儿童腺样体肥大的X线表现

目的：探讨X线鼻咽侧位平片表现及评价测量腺样体/鼻咽腔（A/N）比值的临床应用价值.材料与方法：病变组213例中,男134例,女79例;正常组46例中,男22例,女24例.均常规摄吸气期鼻咽侧位平片和测量A/N比值.结果：（1）病变组：鼻咽顶后壁软组织增厚,鼻咽腔变窄;全部213例A/N比值≥0.61,101例A/N≥0.71.（2）正常组：A/N比值均＜0.6为正常,鼻咽顶后壁软组织边缘不凸出或轻微凸出.结论：（1）摄吸气时的鼻咽侧位片是观察腺样体肥大的简单而准确的方法;（2）测量A/N比值用以观察腺样体肥大的程度,A/N≤0.60为正常,≥0.61为腺样体肥大,≥0.71者为腺样体显著肥大.（3）测量A/N对选择腺样体刮除术具有一定的临床价值.     

胆固醇、SAAG、CEA和CA199对良恶性腹水鉴别诊断意义

目的探讨癌胚抗原(CEA)、癌抗原199(CA199)、胆固醇(Ch)和血清-腹水白蛋白梯度(SAAG)检测对良恶性腹水的鉴别价值。方法检测54例恶性腹水、48例良性腹水中CEA、CA199、Ch和ALB水平,同时在±0.5h内检测血清ALB,计算SAAG。并计算CEA、CA199、Ch和SAAG诊断性能指标。结果恶性腹水CEA、CA199、Ch和SAAG检测水平明显高于良性腹水,差异有极显著性(P<0.001)。从敏感性和有效率看,均以Ch最高,CA199最低,但CA199特异性为100%。CEA+CA199+Ch联合检测敏感性为90.7%,特异性为100%。结论CEA、CA199、Ch和SAAG检测对良恶性腹水具有鉴别价值,CEA+CA199+Ch联合检测对鉴别良恶性胸腹水具有十分重要的意义。     

颈廓清术在咽喉部癌放疗后颈部残留或复发灶应用的初步探讨

本文报告对4例晚期鼻咽癌及3例晚期喉癌,在根治量放疗已控制原发灶而颈部包块仍不消退或复发的情况下,施行挽救性颈廓清术8侧,有效地改善了病人生存质量;认为,只要各方面处理得当,不应轻易放弃放疗失败病例的手术机会。     

希罗达联合多西他赛或伊立替康治疗晚期胃癌的临床对照研究

目的 比较多西他赛与伊立替康分别联合希罗迭治疗晚期胃癌的近期疗效和不良反应. 方法 65例患者随机分为两组,A组33例应用多西他赛联合希罗达,B组32例联合应用多西他赛、伊立替康和联合希罗达,均化疗2周期以上. 结果 A组有效18例(54.54%),中位无进展生存期(PFS)为6.1个月;B组分别为17例(53.13%)和6.2个月(均P>0.05).A组贫血较重,B组腹泻较重. 结论 两种方案对晚期胃癌患者均有较好疗效且疗效相当,不良反应可以耐受.