52例疤痕子宫妊娠分娩方式的临床研究

目的分析研究疤痕子宫妊娠不同的分娩方式对产妇的影响,选择其合理的分娩方式。方法回顾性分析2004年11月至2012年11月期间我科收治的52例剖宫产术后疤痕子宫妊娠患者的临床资料,观察不同分娩方式的临床疗效。结果阴道分娩27例,占51.92%,再次剖宫产25例,占48.08%。阴道分娩组的新生儿评分与剖宫产组无统计学差异（P〉0.05）。剖宫产组的产后并发症发生率、住院时间都明显高于阴道分娩组（P〈0.05）。结论疤痕子宫再次妊娠并非是剖宫产的绝对指征,符合试产条件的,在严密观察监护下是可以经阴道试产的。     

Formaldehyde and Glutaraldehyde and Nasal Cytotoxicity: Case Study Within the Context of the 2006 IPCS Human Framework for the Analysis of a Cancer Mode of Action for Humans

Formaldehyde and glutaraldehyde cause toxicity to the nasal epithelium of rats and mice upon inhalation. In addition, formaldehyde above certain concentrations induces dose-related increases in nasal tumors in rats and mice, but glutaraldehyde does not. Using the 2006 IPCS human framework for the analysis of cancer mode of action (MOA), an MOA for formaldehyde was formulated and its relevance was tested against the properties of the noncarcinogenic glutaraldehyde. These compounds produce similar patterns of response in histopathology and in genotoxicity tests (although formaldehyde has been much more extensively tested studied). The MOA is based on the induction of sustained cytotoxicity and reparative cell proliferation induced by formaldehyde at concentrations that also induce nasal tumors upon long-term exposure. Data on dose dependency and temporal relationships of key events are consistent with this MOA. While a genotoxic MOA can never be ruled out for a compound that is clearly genotoxic, at least in vitro, the nongenotoxic properties fundamental to the proposed MOA can explain the neoplastic response in the nose and may be more informative than genotoxicity in risk assessment. It is not yet fully explained why glutaraldehyde remains noncarcinogenic upon inhalation, but its greater inherent toxicity may be a key factor. The dual aldehyde functions in glutaraldehyde are likely to produce damage resulting in fewer kinetic possibilities (particularly for proteins involved in differentiation control) and lower potential for repair (nucleic acids) than would be the case for formaldehyde. While there have been few studies of possible glutaraldehyde-associated cancer, the evidence that formaldehyde is a human carcinogen is strong for nasopharyngeal cancers, although less so for sinonasal cancers. This apparent discrepancy could be due in part to the classification of human nasal tumors with tumors of the sinuses, which would receive much less exposure to inhaled formaldehyde. Evaluation of the human relevance of the proposed MOA of formaldehyde in rodents is restricted by human data limitations, although the key events are plausible. It is clear that the human relevance of the formaldehyde MOA in rodents cannot be excluded on either kinetic or dynamic grounds.     

高等中医药院校《中药鉴定学》课程ITPA立体教学模式探讨

《中药鉴定学》是全国高等中医药院校中药学类专业培养方案构架中极具中医药特色的一门核心专业课程.教学组在30多年的教学过程中,积累了丰富的教学经验,针对社会对中药鉴定人才的需求现状,建立了较为完善的《中药鉴定学》ITPA （Interest cultivation-Theory teachingPractice＆amp;Experiment teaching-Assessment）教学模式,即“兴趣培养-理论教学-实践（验）教学-考核评价”教学模式.《中药鉴定学》ITPA教学模式是培养中药鉴定学综合素质人才的有效手段.     

线性爆破模式在晶状体超声乳化术中的应用

目的 观察线性爆破超声能量模式在晶状体超声乳化吸出术中应用的临床效果.方法 将400例（400眼）白内障随机分为连续、脉冲、爆破及线性爆破模式4组,分别采用连续、脉冲、爆破及线性爆破超声能量模式行超声乳化吸出人工晶状体植入术.术中记录4组使用的实际超声时间,计算累计超声能量（平均超声能量与实际超声时间的乘积）,检查术后视力、角膜内皮细胞密度,并观察角膜水肿及手术并发症的发生情况.结果 线性爆破超声能量模式组较其他3组的实际超声时间明显缩短,累计超声能量明显减少,术后第1天视力提高明显,角膜内皮细胞密度损失少,角膜水肿发生率低;其差异均有统计学意义.结论 线性爆破模式是一种损伤轻效果好,一种新型的白内障超声乳化的手术方法.     

药物分析课程“学研并进”的教学模式探索

在药物分析课程中采用"学研并进"的教学模式,理论课讲授概念的同时增加案例教学,注重概念与实验方法的学习;实验课以药物含量测定方法建立与评价为任务,通过实验方案设计、完善、实施和总结不断深化学生对基本概念的理解。     

无支架人工二尖瓣置换术的实验研究

目的　建立犬无支架带腱索人工二尖瓣置换的动物模型。方法　实验动物采用成年杂种犬 ,左侧胸壁切口 ,低温体外循环下经二尖瓣口行带腱索人工二尖瓣置换 ,人工腱索直接与乳头肌缝合。结果　手术过程顺利 ,顺利脱离体外循环 ,术后按人工心脏瓣膜置换术后常规处理 ,实验犬 8例全部长期存活 ,建立了稳定的动物模型。结论　经二尖瓣口行带腱索人工二尖瓣置换可作为该种人工心脏瓣膜的手术植入方式 ,动物模型可用于带腱索人工二尖瓣的实验研究。     

医学模式的转变与图书馆服务功能之拓展

医学模式的转变促进医院图书馆服务功能的拓展,图书馆必须与时俱进开展创新服务,面向读者进行健康教育及素质教育,开展为病人有偿服务及深化读者信息服务,才能确保医院图书馆的生存和发展。     

Mode of action of antimicrobial peptide P45 on Listeria monocytogenes

The mode of action of an antimicrobial peptide produced by Bacillus sp. P45 isolated from the intestine of the Amazonian basin fish Piaractus mesopotamicus was investigated. The antimicrobial peptide was purified from culture supernatants by precipitation with ammonium sulfate and gel filtration chromatography. The peptide has an EC(50) of 300 AU (activity units) ml(-1) and kills all viable cells of Listeria monocytogenes with a concentration of 800 AU ml(-1). A decrease in OD was observed when L. monocytogenes cultures were treated with the peptide, suggesting that cells were lysed. Transmission electron microscopy showed damage of the cell envelope and loss of protoplasmic material. The peptide P45 was bactericidal and bacteriolytic to L. monocytogenes. There is evidence that the mode of action is interfering at cell membranes and the cell wall. The knowledge of the mode of action of antimicrobial peptides is an essential step to consider their utilization in food or clinic.     

小组合作学习在社区健康护理教学中的应用

社区健康护理是以社区为单位,以社会学、管理学、预防医学、人际交流与沟通等知识为基础,运用护理程序的方法,对社区的自然环境和社会环境以及社区人群的健康进行管理的过程。社区健康护理在我国起步较晚。目前,国内外最常用的社区健康护理模式为安德逊的“社区作为服务对象”的模式。     

剑川县217例白族乙型肝炎患者血清乙肝病毒感染模式分析

[目的]探讨白族乙肝患者乙肝病毒感染模式。[方法]对2007~2008年剑川县经医院确诊的和流行病学调查中发现的白族乙肝患者217例进行乙肝病毒血清标志物检测。[结果]检测217例,HBsAg阳性率为97.70%,抗-HBs阳性率为4.15%,HBeAg阳性率为35.48%,抗-HBe阳性率为59.45%,抗-HBc阳性率为84.79%。检出10种感染模式,HBsAg、HBeAg、抗-HBc均阳性者占17.05%,HBsAg、抗-HBe、抗-HBc均阳性者占44.70%。[结论]白族乙肝患者HBV血清感染标志物模式复杂,抗-HBs阳性率很低。