Accumulation of smooth cisterns,multivesicular bodies and “zebra” bodies in neurons

Summary The ultrastructural and biochemical study of cerebral and liver biopsies from a two-year-old boy with 20 month history of psychomotor retardation, hypotonia and hyporeflexia is presented. Although the case cannot be considered, at the present time, as a separate entity in view of the failure of the biochemical studies of identifying the stored material, the ultrastructural features, which include clustered agranular cisterns of endoplasmic reticulum and numerous multivesicular bodies and zebra bodies in neurons, indicate a storage disorder morphologically different from those reported to date. In the present case, morphological and cytochemical findings suggest that the agranular endoplasmic reticulum may give trise to multivesicular bodies which, in turn, may become dense bodies and zebra bodies.Supported by U.S.P.H.S. Grants NS 05572-06, NS 08933-01, NS 08420-02, NIN FR 75, by the Inex J. Warriner Memorial Grant for Research in Multiple Sclerosis (670-A-1) from the National Multiple Sclerosis Society.     

掌握特点 积极探索 努力克服红包现象

本文剖析了红包现象具有的普遍性、隐蔽性、顽固性、诱惑性这四性的特点及对医院正常管理和全面建设的危害。提出了消除红包现象的具体措施。加强一个教育:即加强医德医风教育,提高医务人员的思想觉悟,增加自觉抵制红包现象的免疫力。引导大家摆正两个关系:即社会效益和经济效益的关系;医疗技术和医德医风的关系。抓好三个环节:即树立典型、加强宣传;严格规章制度,加强检查监督;奖惩分明,狠抓落实。     

Safety evaluation of the mixture of chemicals at a specific workplace: theoretical considerations and a suggested two-step procedure

Procedures for the selection of compounds with high health hazard potential are reviewed, and major aspects of the assessment of health risks associated with exposure to mixtures of chemicals are discussed. Examples are given of additivity and synergism of effects following exposure to mixtures. Using these data from the literature a two-step procedure for the safety evaluation of the mixture of chemicals occurring at a specific workplace is suggested. The first step consists of estimating the relative health risk associated with each chemical; the estimation is based on the ratio between exposure level and degree of toxicity. Those chemicals representing a high risk are then selected for further consideration. The second step comprises the risk assessment, focusing on prediction of the risk associated with exposure to the mixture of selected chemicals. To allow such prediction the (presumable) mode of action of the selected compounds should be considered. A practical way to find out whether exposure to chemicals at a specific workplace is of serious health concern, could be the conduct of both a 4-week toxicity study in rats and 2 different types of genotoxicity studies with the mixture of selected chemicals, using exposure concentrations related to those occurring in practice.     

Anti-hypertensive Action of Labetalol: A Detailed Profile

Abstract: Anti-hypertensive action of labetalol: a detailed profile. G. R. Bellamy, S. N. Hunyor, D. Roffe and J. Massang. Aust. N.Z. J. Med., 1982, 12 , pp. 467–472.
Continuous, ambulatory blood pressure (BP) and self measured home recordings were used to study the response of ten mild to moderate hypertensives taking a twice daily labetalol dosage. Testing of cardiovascular reflexes was carried out 12 hours after a dose of drug.
The mean 24 hour BP was reduced from 145/80±14/7 (SD) mmHg to 130/71±11/6 (p<0001) and home BP from 147196 ± 1519 to 134/84±10/9 (p<001). The predominant effect of labetalol was evident during the waking hours. A residual 9-5% BP reduction was seen 12 hours after a dose compared to an 11% lowering effect over the entire 24 hours (NS). No symptomatic hypotensive episodes were noted.
Significant inhibition of heart rate and BP rise during dynamic exercise (P<001) and reduction of post-release BP "overshoot" (P<001) in Valsalva's manoeuvre indicated a beta adrenoceptor blocking effect. There was however a reduction in the rate of rise of BP during static handgrip (

This study has demonstrated the efficacy of a twice daily regimen of labetalol in continuously lowering BP. The mode of action of the drug during exercise (static and dynamic) and Valsalva's manoeuvre would indicate a predominant beta adrenoceptor blocking action.     

A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat

Prolonged treatment with high doses of Pyrethrins results in thyroid gland tumors in the rat. To elucidate the mode of action for tumor formation, the effect of Pyrethrins on rat thyroid gland, thyroid hormone levels and hepatic thyroxine UDPglucuronosyltransferase activity was investigated. Male Sprague-Dawley CD rats were fed diets containing 0 (control) and 8000 ppm Pyrethrins and female rats diets containing 0, 100, 3000 and 8000 ppm Pyrethrins for periods of 7, 14 and 42 days and for 42 days followed by 42 days of reversal. As a positive control, rats were also fed diets containing 1200-1558 ppm sodium Phenobarbital (NaPB) for 7 and 14 days. The treatment of male rats with 8000 ppm Pyrethrins, female rats with 3000 and 8000 ppm Pyrethrins and both sexes with NaPB resulted in increased thyroid gland weights, which were associated with follicular cell hypertrophy. Thyroid follicular cell replicative DNA synthesis was increased by treatment with Pyrethrins and NaPB for 7 and/or 14 days. Treatment with Pyrethrins and NaPB increased hepatic microsomal thyroxine UDPglucuronosyltransferase activity and serum thyroid stimulating hormone levels (TSH), but reduced serum levels of either thyroxine (T4) and/or triiodothyronine (T3). The effects of Pyrethrins in female rats were dose-dependent, with 100 ppm being a no-effect level, and on cessation of treatment were essentially reversible in both sexes. The concordance between the effects of Pyrethrins and NaPB suggests that the mode of action for Pyrethrins-induced rat thyroid gland tumors is similar to that of some other non-genotoxic inducers of hepatic xenobiotic metabolism.     

Measuring Lifetime Drinking Histories

This paper is based on the session "Measuring Lifetime Drinking Histories" that was held on Tuesday May 13,1997 at the International Workshop on Consumption Measures and Models for Use in Policy Development and Evaluation. The session chair was Paul Lemmens; presenters were Marcia Russell, Ronald Knibbe, and Paul Lemmens; and panel discussants were Robin Room, John Searles, Linda Sobell, and Richard Wilsnack.     

微无创医学人才培养体系的创建与实践

大型医疗器械产业的飞速发展使医学治疗技术有了突破性进展,微无创医学成为未来医学发展的趋势。重庆医科大学为适应医学发展需求,积极进行微无创医学人才培养,在培养理念和目标定位、课程体系与教学内容构建、教学团队建设以及实践创新能力培养等方面进行探索和实践,为微无创医学领域填补了人才空白。     

重庆市某三甲医院新进人员岗前培训影响因素及对策

目的：通过对重庆某三甲医院开展新进人员岗前培训6年经验的总结,找出影响岗前培训效果的相关因素,并进一步完善医院对新进员工的岗前培训体系。方法：采用问卷方法对医院2007年-2012年参加岗前培训的新员工进行匿名调查,并使用Excel进行数据录入和统计。结果：培训学员对培训内容的总体满意度达到93.44%,对培训时间安排总体满意度达到83.19%,对培训教师的表现总体满意度达到94.81%。结论：新进人员岗前培训的内容设计、时间安排以及培训教师的表现等相关因素对培训效果有一定的影响,可以通过对这些因素的分析,帮助医院不断改进岗前培训安排,不断完善岗前培训体系。     

激光闭合联合点式剥脱术与激光闭合联合泡沫硬化剂注射术治疗下肢静脉曲张的临床疗效比较

目的比较激光闭合联合泡沫硬化剂注射术与激光闭合联合点式剥脱术治疗下肢大隐静脉曲张的疗效。方法选取大隐静脉曲张患者380例,采用激光闭合联合点式剥脱术和激光闭合联合泡沫硬化剂治疗术。比较手术时间、术后恢复时间、术后并发症、CEAP分级及复发等指标。结果激光闭合联合泡沫硬化剂注射术在手术时间、术后平均恢复时间等方面均较激光闭合联合剥脱术有所缩短,且差异有统计学意义（P〈0．05）。两种手术方式CEAP分级均较术前明显降低,再通率均较低,但组间无显著差异。结论与激光闭合联合剥脱术相比,激光闭合联合泡沫硬化剂注射可以缩短手术时间、术后恢复时间,减少术后并发症,并且能同样达到较好的治疗效果。     

274例巨大儿临床分析

目的探讨预测巨大儿的相关因素及分娩方式选择,降低母婴并发症。方法回顾分析2010年1—12月在该院分娩的巨大儿274例作为观察组,并随机选取同期分娩的274例正常体重儿作为对照组。结果观察组孕妇在孕周、孕产次、产前体重指数、剖宫产率等明显大于对照组,两组分娩并发症亦有显著差异。结论做好巨大儿的预防,选择合适的分娩方式,有助于减少巨大儿的发生,降低母婴并发症。