腹部动脉能谱CT混合能量与单能量图像的比较研究

目的通过比较腹部动脉能谱CT成像中混合能量重建模式图像与单能量重建模式图像的质量,筛选适宜观察腹部动脉的图像重建模式。方法 80例患者采用GE公司的宝石CT能谱成像技术,获得腹部动脉混合能量图像（140kVp）和40-140keV范围内的单能量图像。对混合能量图像和单能量图像进行感兴趣区CT值的测量,计算腹主动脉、肝动脉的SNR和CNR;各组图像由三名有经验的放射医师采用盲法进行图像质量主观评分。最后进行腹部动脉CT值、SNR、CNR和图像质量主观评分的综合比较。所获数据采用SPSS 19.0软件进行统计学分析。结果随着keV值的降低,腹部动脉CT值逐渐升高,图像噪声同时发生改变。根据腹部动脉图像质量的客观指标（CT值、SNR和CNR）和主观评分,对混合能量图像与各组单能量图像进行综合比较,结果显示50-60keV单能量组腹部动脉图像质量优于混合能量组,同时单能量成像对腹主动脉和肝动脉图像质量的影响存在差别。结论在腹部能谱CT常规增强扫描所获得的腹部动脉不同类型重建图像中,50-60keV单能量重建模式的图像质量优于混合能量重建模式,推荐其作为腹部动脉能谱CT扫描的常规重建模式。     

医学图书馆移动服务模式探讨

探讨医学图书馆移动信息资源服务模式,包括手机微博、二维码、流媒体服务、手机定位导航、支付服务、短信服务、基于浏览器的服务、多种输入形态的移动检索、互动参考咨询、在线书刊展览、信息推送、手机电视、移动应用程序等,以更好地满足读者需求.     

基于工作过程的中药制剂技能型人才培养模式的研究

本文分析了中药制剂技能型人才培养的现状,提出了基于工作过程运用八步教学法的中药制剂技能型人才培养模式,介绍了基于工作过程建立中药制剂技能型人才培养的教学资源库建设方案,描述了采用“八步教学法”的教学理念进行人才培养的方法,并归纳总结了本项目的研究内容、研究前景i研究策略、实施途径及研究意义。     

艾滋病患者服药依从性教育效果研究

目的：探讨艾滋病患者不同方式服药依从性教育的效果,为开展艾滋病患者依从性教育提供参考。方法将符合条件高效抗反转录病毒治疗的120例艾滋病患者随机分成对照组,依从性教育A组、B组共三组,每组40例。其中,对照组由医务人员对患者进行服药依从性教育;A组在与对照组一致的依从性教育的基础上,同时进行同伴教育;B组在与对照组一致的依从性教育的基础上,家属对患者进行依从性教育及关爱。随访1年,比较不同组别患者的服药依从性。结果对照组、A组、B组依从性达到95%以上的百分比分别是82.5%、85%、100%,三组依从性比较差异有显著性（P〈0.01）,B组的依从性优于对照组和A组。结论采用医务人员、家庭成员联合对患者进行服药依从性教育方式成效显著,值得推荐。     

Axial Transmission Method for Long Bone Fracture Evaluation by Ultrasonic Guided Waves: Simulation,Phantom and in Vitro Experiments

Mode conversion occurs when the ultrasonic guided waves encounter fractures. The aim of this study was to investigate the feasibility of fracture assessment in long cortical bone using guided-mode conversion. Mode conversion behavior between the fundamental modes S0 and A0 was analyzed. The expressions proposed for modal velocity were used to identify the original and converted modes. Simulations and phantom experiments were performed using 1.0-mm-thick steel plates with a notch width of 0.5 mm and notch depths of 0.2, 0.4, 0.6 and 0.8 mm. Furthermore, in vitro experiments were carried out on nine ovine tibias with 1.0-mm-wide partial transverse gap break and cortical thickness varying from 2.10 to 3.88 mm. The study confirmed that mode conversion gradually becomes observable as fracture depth increases. Energy percentages of the converted modes correlated strongly with fracture depth, as illustrated by the frequency-sweeping experiments on steel phantoms (100–1100 kHz, r² = 0.97, p < 0.0069) and the fixed-frequency experiments on nine ovine tibias (250 kHz, r² = 0.97, p < 0.0056). The approaches described, including mode excitation, velocity expressions and energy percentage criteria, may also contribute to ultrasonic monitoring of long bone fracture healing.     

湖北省中外合作办学护理人才培养模式的现状及发展研究

尝试从培养模式的角度,分析湖北省中外合作办学护理人才培养模式的现状,找出存在的问题,提出相应的发展建议,以期对中外合作办学护理人才培养的可持续发展提供有益借鉴。     

多孔碳酸钙陶瓷修复骨缺损的实验研究

目的 探讨多孔碳酸钙陶瓷修复骨缺损的可行性。方法 取20只新西兰大白兔，采用兔桡骨干1．5cm缺损的动物模型并植入多孔CaCO3陶瓷，分别于术后2、4、8、12及16周处死后取材，行大体、X线、扫描电镜和组织切片观察。结果 植入材料4周扫描电镜显示材料的骨结合紧密、且无纤维组织界面；组织学观察12周植入材料内有较多板层骨生成、植入材料被吸收，骨缺损得到修复。结论 多孔CaCO3陶瓷具有良好的生物相容性和降解率，是一种替代自体骨修复骨缺损较理想材料。     

Evidence for a dissociation between positive inotropic effect and inhibition of the Na+-K+-ATPase by ouabain, cassaine and their alkylating derivatives

An attempt was made to gain further information on the correlation postulated between NaK-ATPase activity and the contractile state of heart muscle. The efficiency of a new alkylating agent, cassic acid mustard (CAM) on contractile force and on the NaK-ATPase was compared with cassaine (C) and ouabain (S). The ED₅₀ valuess obtained in isolated guinea-pig atria were (× 10^?7 M): C 0.9, CAM 2.7 and S 1.1; the ID₅₀ values resulting from ATPase inhibition experiments were (× 10^?6 M): C 1.0, CAM 24, and S 0.25. Low concentrations of all three drugs stimulated the ATPase activity up to 20%. The time course of stimulation is characterized by a half-life of 5 min at a concentration of 1 × 10^?0 M ouabain. A considerable discrepancy exists between the time courses of onset of the positive inotropic effect and the development of enzyme inhibition. This is most obvious in the case of ouabain: a drug concentration of 1 × 10^?7 M produces a positive inotropic equilibrium within 30 min, whereas the inhibition of the enzyme still continues after a period of more than 60 min. A positive inotropic effect of 80% can be washed out a half lives of 8.3 min for CAM, 2.8 min for C and 4.4 min for S. In contrast to this ready reversibility of the positive inotropic effect, the enzyme inhibition by S is not reversible and persists for more than 30 min upon dilution of the drug-enzyme complex. The data obtained are consistent with the interpretation, that the Na⁺K⁺? ATPase is not the mediator of the positive inotropic action of digitalis and related compounds. It is much more tempting to correlate ATPase inhibition with the toxic effects of these compounds.     

Tendenzen der systemischen Glucocorticoid-(GC)-Therapie

Ohne Zusammenfassung

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