文化大革命的起源探析

本文认为毛泽东发动“文革”的根本原因是他希望创造一个“新世界”。建国以来党内“左”倾错误的发展使党提出以“阶级斗争为纲”的口号，毛泽东认为“三面红旗”的正确性不容置疑，任何怀疑、否定“三面红旗”的做法，他都认为是修正主义的表现，赫鲁晓夫情结使他认为党内出现了“睡在身边的赫鲁晓夫”，而中苏论战使“左”倾错误理论化、系统化，在以上因素影响下文化大革命发生了。     

感冒热毒清口服液的研制及临床应用

目的：研制治疗病毒或细菌感染引起的呼吸道感染而无不良反应的纯中药口服液,以满足临床感冒患者的需要,方法：制定感冒热毒清口服液制备工艺,质量标准,临床使用方法。结果：本制剂制备工艺,可行,性质稳定,质量控制方法可靠,结论：感冒热毒清口服液治疗感冒效果好,疗效快,无不良反应,服用方便 ,值得推广。     

运用子午流注纳支法辨治疑难杂病验案6则

介绍十二时辰配属十二经脉的子午流注纳支法在辨治疑难杂病中的应用经验。并举巳时心痛、辰时咳嗽、丑时脊问痛、寅时心悸欲厥、蛛网膜囊肿开窗手术后亥时颌下剧痛、子时汗出浸衣等6则医案。     

毛泽东的书法艺术观

毛泽东的书法理论散见在各类著述中，仔细发掘，甚为可观，且大致构成体系。其书法观概括起来有如下几点：①指出书法是一门艺术；②肯定书法用处大；③支持学术争鸣；④揭示学好书法的必由之路。毛泽东的书法艺术观是鲜明深刻的，闪耀着毛泽东思想的巨大光辉。     

毛德西教授的从医之路和治学经验

目的：总结毛德西教授的从医之路和治学经验。方法：通过跟师学习,收集、整理全国名老中医毛德西的从医历程及其＂读经典,勤临床,拜名师,多总结＂的从医之路和治学经验。结果：毛德西秉承医圣＂勤求古训,博采众方＂和孙思邈＂博极医源,精勤不倦＂之训,临证经验日渐丰富,学术思想日臻完善,对中医的认识日渐升华。＂读经典,勤临床,拜名师,多总结＂,寥寥数语,见证了一代中医临床大家的成长历程,凝聚着中医名家的济世之心。结论：毛德西教授从50多年来从最初的被动接触中医到后来主动学习中医,再到对中医产生浓厚兴趣,先生在学习中体会中医,在体会中思考中医,在思考中传承中医。     

Curculigo orchioides (Xian Mao) modifies the activity and protein expression of CYP3A in normal and Kidney-Yang Deficiency model rats

Aim of the study

In Chinese medicine clinics, traditional Chinese herbs are used to treat disorders of Yin and Yang balance, including Kidney-Yang Deficiency. The activity of the hepatic cytochrome P450 3 A (CYP3A) is closely associated with body status. The aim of the present study is to investigate CYP3A enzymatic activity and CYP3A4 protein expression using a Kidney-Yang Deficiency rat model and furthermore to investigate the intervention effects of the Pungent-hot herb Xian Mao. This work contributes rationale for personalized medicine and enhances our understanding of herb–drug interactions.

Materials and methods

Rats were randomly divided into three groups: the model group, the Xian Mao group and the intervention group (model rats treated with Xian Mao). The model rats were given an intramuscular injection of hydrocortisone for 14 days, and the control rats were given normal saline. The Xian Mao group consisted of normal rats treated with Xian Mao by oral gavage for 7 days. The intervention group was given Xian Mao for 7 days after treatment with hydrocortisone. The activity of CYP3A was detected by using the erythromycin-N-demethylase method. CYP3A4 protein expression level was detected by Western-blot.

Results

CYP3A enzymatic activity in the Kidney-Yang Deficiency rat was decreased by 44% compared to normal animals. The relative CYP3A4 protein expression level of the Kidney-Yang Deficiency rat (mean value 0.663±0.188) was 20% lower than that of normal rat (0.830±0.199). The in vitro data showed that CYP3A activity was significantly (P<0.001) inhibited (decreased by 59%) by Xian Mao concentrations of 1 mg/mL. The in vivo data also showed that CYP3A activity was significantly decreased in the rats treated with the three doses of Xian Mao. The CYP3A4 protein expression was significantly decreased by Xian Mao treatment at the high and intermediate doses (30 and 20 g/kg, respectively) compared with the normal group. However, the intervention group (the Kidney-Yang Deficiency rat treated with Xian Mao at 20 and 30 g/kg) showed an increased CYP3A activity and CYP3A4 protein expression compared with the herb-untreated model rats.

Conclusion

CYP3A enzymatic activity and CYP3A4 protein expression could be inhibited by Xian Mao. The CYP3A activity and CYP3A4 expression in the Kidney-Yang Deficiency model rat were lower than that of normal rat but this deficiency could be rescued by treatment with Xian Mao.     

《医门擥要》主要学术观点的研究

在上期发表的《医门肇要》主要内容的统计分析的基础上，又对《医门擎要》主要学术观点进行了研究整理。提出该书诊断强调四诊合参；治病贵在辨证论治、师古不泥；立法注重三因制宜；五脏之中重在脾肾的学术思想。认为该书具有完整而系统的医学体系和丰富而鲜明的学术观点。深入研究该书对考证以发源于中原地区为主的中医学是如何融入云南民族医药之中的，理清云南民族医药发展脉络，探求其学术渊源等都具有重要理论价值和临床实际应用价值。     

不忘初心送瘟神 科学防治谱新篇——纪念毛泽东主席《七律二首·送瘟神》发表60周年

本文回顾了毛泽东主席《七律二首·送瘟神》发表60周年来,对我国血吸虫病防治工作的巨大推动作用,以及我国所取得的巨大防治成就。《七律二首·送瘟神》的发表,推动了我国血吸虫病防治机制的建立,而当年的“余江血防精神”,在今天仍将是我国从控制走向消除血吸虫病的血防工作源动力。我们纪念《七律二首·送瘟神》发表60周年,就是要不忘伟人的初心,不忘共产党人为人民服务的初心,以不达目标、决不罢休的“余江血防精神”,坚持依法防治、科学防治、因地制宜原则,加速全面推进我国消除血吸虫病进程,为实现健康中国梦的宏伟目标作出我们的贡献。     

The effect of a herbal medicine (Mao-to) for the prevention of interferon-induced psychiatric complications in chronic hepatitis C: a pilot study

OBJECTIVE: To evaluate the efficacy of a herbal medicine (Mao-to) on psychiatric complications caused by IFN, and to examine the relationship between depression and microcirculation. METHODS: Twelve patients with chronic hepatitis C and a past history of IFN-induced depression were enrolled in this study. Their mental state was evaluated by the self-rating depression scale (SDS)> or =40, or M-R of the Cornell medical index (CMI)> or =10. Each patient received a daily dose of 6 million units of IFN-beta for 8 weeks, and Mao-to was given orally four times a day during the IFN-beta course. RESULTS: All patients in this study completed a full course of IFN. Mean CMI scores (M-R) had significantly decreased at the end of the treatment. Mean erythrocyte aggregability and erythrocyte deformability had also significantly decreased at the end of treatment. CONCLUSION: Mao-to might be useful for preventing the incidence of depression in patients with chronic hepatitis C being treated with IFN. The mechanism by which Mao-to prevents depression is suggested to be through the improvement of microcirculation.