MAC行结肠镜检查的临床研究

目的研究电子结肠镜检查治疗中应用异丙酚、芬太尼进行监测麻醉(MAC)时的可行性和安全性。方法240例结肠镜检查患者分两组:MAC组(n=140)静脉注射异丙酚、芬太尼后进行结肠镜检查,对照组(n=100)按常规进行结肠镜检查。比较:①MAC组和对照组患者的不良反应,检查前、中、后血压、心率、呼吸频率及血氧饱和度的变化;②MAC组患者镇静状态(RAMSAY法)、苏醒后的记忆和感受。结果①MAC组躁动的发生率为2.1%,而对照组为57%(P<0.001);MAC组患者检查中血压、心率及血氧饱和度平稳,而对照组中BP、HR都有不同程度升高;②MAC组患者10%达到2级镇静状态,70%达到3级镇静状态20%达到4级镇静状态,清醒时间为(3.9±2.5)min,全部MAC组无并发症发生,对结肠镜检查过程无记忆及不良感受。结论异丙酚、芬太尼应用于无痛结肠镜检查安全、有效。     

Laryngitis after inhalation of liposomal amikacin

A 56‐year‐old woman with pulmonary Mycobacterium avium complex disease was started on inhalation liposomal amikacin. One month later, she developed hoarseness and was diagnosed with laryngitis. The laryngitis healed immediately after treatment discontinuation, and no recurrence occurred even after resuming intermittent inhalation.