米非司酮应用于子宫内膜异位症患者的疗效观察123例

目的探讨米非司酮应用于子宫内膜异位症的疗效。方法 123例子宫内膜异位症患者被随机分为实验组(n=63)和对照组(n=60),两组均给予手术治疗,实验组在手术治疗基础上给予米非司酮治疗方案。结果实验组总有效率为95.2%,痊愈率为84.1%,对照组总有效率为56.7%,痊愈率为43.3%,实验组效果显著优于对照组(P<0.01)。结论手术治疗联合米非司酮应用于高血压脑出血,能提高手术效果,降低复发率,值得在临床上应用和推广。     

丁香郁金配伍的药理研究

丁香郁金配伍属中药配伍禁忌“十九畏”之一，本文就二者单独使用和配伍后的抗炎、镇痛、止泻、抗溃疡等指标进行了动物药效学试验。二药配伍后镇痛、抗炎及止泻作用有下降趋势；抗溃疡作用不受影响；对试验动物胸腺指数和脾脏指数无明显影响。实验结果，二者配伍似属“相恶”。     

2种清洗设备洗涤医用器械的质量分析

目的通过观察全自动清洗消毒器与超声波清洗机洗涤不同类医用器械的质量,找出不同器械的最佳洗涤方法,为制订各种器械洗涤流程提供依据。方法将回收器械随机分为A洗涤法和B洗涤法。A洗涤法:将回收器械直接放入全自动清洗消毒器内按程序进行清洗、消毒和干燥。B洗涤法:将器械放入超声波机内按程序加酶浸泡、超声波清洗、冷水热水喷淋清洗消毒、上油烘干。比较2种洗涤方法的洗涤效果。结果A洗涤法洗涤后齿类器械剩余残留物为0.52‰,非齿类器械剩余残留物为0.07‰,2种器械洗涤效果差异有统计学意义(!2=28.189,P=0.000),洗涤齿类器械效果差;B洗涤法洗涤齿类器械剩余残留物为0.04‰,非齿类器械剩余残留物为0.01‰,2种器械洗涤效果差异无统计学意义(!2=1.008,P=0.313)。而2组洗涤法洗涤齿类器械效果有统计学意义(!2=44.097,P=0.000);非齿类器械洗涤后剩余残留物对比不明显,洗涤效果差异无统计学意义(!2=2.667,P=0.102)。结论采用超声波清洗机清洗齿类器械洗涤效果佳;而采用全自动清洗消毒器洗涤齿类器械洗涤效果差,但洗涤非齿类器械洗涤容量大,效果好。     

医院统计在医院要素分配中的作用

目的 为支持医院内部要素分配调整改革，医院统计应展开与要素分配有关的项目进行统计，为医院要素分配向高、精、尖、绩效好的医务人员倾斜提供统计数据。方法 应用ExCEL软件的合并功能对病人信息和病案信息进行深层次的挖掘、提取、重新整合统计，制成简明易懂的统计报表给予反馈公布，作为医师提取个人奖酬、职称晋升或聘任竞岗的考核依据。结果通过统计作用实现了劳动价值创造，调动了广大医务人员的积极性，促使医院经营理念成为引导个人自觉行为的杠杆，实现了医院提高综合竞争实力的整体效应。结论 要素分配中统计工作应遵循公平、合理、反映医院经营理念的原则和利用网络科技实现高效管理并且应与改革同步，深化统计内涵，完善医院的统计方法。     

麻疹发病的影响因素分析

目的探讨我区麻疹发生的影响因素并测算我区当前使用的麻疹疫苗效力。方法按单纯随机抽样方法选择实验室证实的临床诊断麻疹病例;按照同性别、同班级或互为邻居、年龄相差在2岁范围内的规定标准选择对照,进行1∶2配比病例对照研究,并采用卡方检验和多因素条件Logistic回归统计处理方法分析其主要影响因素。结果麻疹疫苗效力(VE)为79.39%;麻疹疫苗接种史在病例组与对照组之间有统计学意义(χ2=26.04,P<0.05),麻疹发病的比值比(OR值)为0.21,95%的可信区间为0.12-0.50;进入Logistic回归方程的变量为麻疹疫苗接种史、家长对预防接种的态度、家庭经济收入,其回归系数分别为4.75,3.10,2.97。结论我区目前使用的麻疹疫苗效力为79.39%,对接种人群有很好的保护作用;未接种麻疹疫苗者的比重在病例组明显为高;不做预防接种是引发麻疹最大的危险因素,家长对预防接种的态度和家庭经济收入对麻疹的发病有统计学关联。     

Independent component analysis and clustering improve signal-to-noise ratio for statistical analysis of event-related potentials

OBJECTIVE: To evaluate the effectiveness of a new method of using Independent Component Analysis (ICA) and k-means clustering to increase the signal-to-noise ratio of Event-Related Potential (ERP) measurements while permitting standard statistical comparisons to be made despite the inter-subject variations characteristic of ICA. METHODS: Per-subject ICA results were used to create a channel pool, with unequal weights, that could be applied consistently across subjects. Signals derived from this and other pooling schemes, and from unpooled electrodes, were subjected to identical statistical analysis of the N170 own-face effect in a Joe/No Joe face recognition paradigm wherein participants monitored for a target face (Joe) presented amongst other unfamiliar faces and their own face. Results between the Joe, unfamiliar face and own face conditions were compared using Cohen's d statistic (square root of signal-to-noise ratio) to measure effect size. RESULTS: When the own-face condition was compared to the Joe and unfamiliar-face conditions, the channel map method increased effect size by a factor ranging from 1.2 to 2.2. These results stand in contrast to previous findings, where conventional pooling schemes failed to reveal an N170 effect to the own-face stimulus (Tanaka JW, Curran T, Porterfield A, Collins D. The activation of pre-existing and acquired face representations: the N250 ERP as an index of face familiarity. J Cogn Neurosci 2006;18:1488-97). Consistent with conventional pooling schemes, the channel map approach showed no reliable differences between the Joe and Unfamiliar face conditions, yielding a decrease in effect size ranging from 0.13 to 0.75. CONCLUSIONS: By increasing the signal-to-noise ratio in the measured waveforms, the channel pool method demonstrated an enhanced sensitivity to the neurophysiological response to own-face relative to other faces. SIGNIFICANCE: By overcoming the characteristic inter-subject variations of ICA, this work allows classic ERP analysis methods to exploit the improved signal-to-noise ratio obtainable with ICA.     

鸡精促进产后乳汁分泌效果的临床观察

目的观察鸡精用于产后乳汁分泌的临床效果。方法产后每日早晚各服白兰氏鸡精70ml，共服3d，并与对照组、中药材催乳组对比。结果鸡精有促进早泌乳与增加泌乳量的作用。结论鸡精用于产妇有滋养身体，恢复产妇体力，促进早泌乳和增加泌乳量的作用，且饮用方便，效果好，无不良反应。     

髋臼骨折的手术治疗

目的：探讨髋臼骨折的手术治疗效果和影响疗效因素。方法：对31例髋臼骨折患进行切开复位由固定治疗。结果：平均随访18个月(6～36月)，根据Matta评分标准优16例，良8例，一般4例，差3例。1例术后发生深部感染，1例术后18个月发生股骨头坏死。结论：髋臼骨折，特别是有移位的髋臼骨折应及时手术治疗。手术医师的经验、骨折类型、手术时机和入路会影响髋臼骨折的疗效。     

中药药性量化方法对补虚药功效归类预测的研究

目的对中药药性依其重要性进行更深层次的多值量化分析,将比定性的文字表述和简单的二值量化表示更有意义.方法以补虚药为研究对象,药性为基本特征,在对其进行二值量化和多值量化的基础上,采用应用人工神经网络和决策树等数据库知识发现技术,进行对补虚药功效归类判别结果的影响研究.结论结果表明药性的不同量化方法对补虚药的功效归类预测有一定影响,多值量化比二值量化具有更为理想的判别结果.     

Synthesis of 9-Halo Prostaglandin Derivatives and Their Effect on Uterus Contraction

Four 9-halo prostaglandin derivatives were designed and synthesized. Their structures were confirmed by IR, ^1HNMR, MS, etc. The effect on uterus contraction of rats was studied in vitro. It was found that compound β-Br seemed to be the most sensitive and β-Cl somewhat less, while α-Cl and α-Br had almost no action as compared with oxytocin (1 IU/ml).