4例活体部分小肠移植术后早期并发症的防治经验

目的总结4例活体部分小肠移植术后早期并发症（1月内）的防治办法，为进一步开展活体小肠移植提供经验。方法4例活体部分小肠移植术后1月内，早期并发症重点在于防治吻合血管血栓、出血、感染、排斥反应、移植肠功能障碍等。结果3例移植受体术后1月内分别发生出血倾向、急性排斥反应、感染、移植肠功能障碍等并发症，但经及时准确的诊断与治疗得以好转，移植肠存活及功能均良好。结论注重活体部分小肠移植术后对于早期并发症的预防及治疗，对于患者预后有重要意义。     

MRI在心脏瓣膜病中的诊断价值

目的 探讨多序列MR扫描在心脏瓣膜病中的诊断价值。方法 回顾性分析56例心脏瓣膜病患者的影像学资料，患者分别采用超声心动图（UCG）、二维（2D）黑血及亮血序列、K-空间节段真实稳态进动快速扫描序列（True FISP）对瓣膜病进行定性评价，15例患者还进行小角度快速激发（FLASH）电影序列和流速编码电影（VEC）定量分析，并将MR结果与UCG进行对比。结果 UCG和MRI诊断二尖瓣狭窄（MS）2例，二尖瓣关闭不全（MI）23例；主动脉瓣狭窄（AS）7例，其中二瓣畸形5例；主动脉瓣关闭不全（AI）13例；三尖瓣关闭不全（TI）2例；复合或联合瓣膜病9例。受累心腔的增大和升主动脉的扩张是其主要形态学改变，异常的血液湍流信号是受累瓣膜的直接征象。VEC-MR定量分析与多普勒超声一致性好：6例AS，MR和UCG检查结果相关性分析，相关系数和校正相关系数分别为：R=0，975、Rsq=0．951（P〈0．01），AI9例，分别为R=0．965、Rsq=0．932（P〈0．01）。结论 MR多序列综合扫描可对心脏瓣膜病特别是主动脉瓣疾病进行准确的定性及定量评价。     

A comparative study of acute and chronic diseases induced by two subgroups of Theiler’s murine encephalomyelitis virus

Theiler’s murine encephalomyelitis viruses (TMEV) are divided into two subgroups on the basis of their different biological activities. The GDVII strain produces acute polioencephalomyelitis in mice, whereas the DA strain produces demyelination with virus persistence in the spinal cord. A comparative study of GDVII and DA strains suggested that low host immune responses are responsible for the development of acute GDVII infection and that the persistence of infected macrophages plays a crucial role in the development of chronic white matter lesions in DA infection. All 78 mice infected with GDVII died or became moribund by day 13, while none of 54 mice infected with DA died. In the acute stage, the distribution of viral antigens in the central nervous system (CNS) tissue was similar in both GDVII and DA infections, although the virus titer was higher in GDVII infection. In DA infection, a substantial number of T cells were recruited to the CNS on day 6 when they were virtually absent in GDVII infection. The titer of neutralizing antibody was already high on day 6 in DA infection but was negligible in GDVII infection. Development of chronic paralytic disease from day 35 of the DA infection was accompanied by focal accumulation of viral antigen-positive macrophages in the spinal white matter. In addition, white matter lesions comparable to those in chronic DA infection were induced in the spinal cord within 7 days after intracerebral injection of DA-infected murine macrophages. Received: 26 June 1995 / Revised, accepted: 27 December 1995     

Quantitative observation by enzyme cytochemistry of human rectal adenocarcinoma cells killed by LAK cells

Activity of succinic dehydrogenase(SDH)and acid phosphatase(AcPase)of effector-target cells during the process of LAK cells killing HR8348 cells was estimated by enzyme cyto-chemistry technique.SHD positive granules and AePase gray level were assayed with MIAS-300image analyser.The results showed:(1)After cocultivation of effector and target cells for vari-ous times,the activity of AcPase of HR8348 cells was apparently higher than that of the controlgroup,and it increased following prolonged coincubation.SDH activity of target cells increasedmarkedly within 30 and 60 rain cocultivation,but became low after 90 min treatment.(2)Ac-Pase content within LAK cells at 60,90,120,180 and 240 rain cocultivation was significantlyhigher than that of control group(P<0.01).The phenomenon of high AcPase and SDH activitywithin effector-target cells indicates that the function of the two types of cells was in an activestate.At the early stage of effector-target combining,the increase of SDH with HR8348 cellsmay be related to defensive function of the target cells.Higher AcPase activity of target cells in-dicates the activation of lysosomal enzyme which serves as the material basis for autolysis of thecells.     

肺系疾病从脾胃论治的探讨

本文论述与肺与脾胃在生理，病理诸方面的密切关系；提出了肺系疾病从脾胃治疗的必要性和重要性；讨论了肺病从脾胃论治之常用７法：即健脾化痰法，芳香醒脾法，健脾利水法，通腑降气法，健脾补肺法，养胃益肺法，补益脾肾法等，对肺系疾病的临床治疗有一定的启发作用和应用价值。     

温州市外来流动人口传染病的监测

目的：为了解温州市流动人口传染病的发病情况，加强这些人群的传染病防制和监测工作。方法：我们对温州市1997－2000年甲，乙类传染病报告资料进行调查，整理和分析。结果：（1）流动人口传染病年均报告发病率为44．75／10万；（2）省外流动人口传染病报告发病率（55．55／10万）高于省内（12．03／10万）；（3）流动人口传染病发病率以呼吸道，肠道，血源和性传播疾病为高，而虫媒与自然疫源性疾病和新生儿破伤风相对较低；（4）流动人口中肺结核，乙肝，甲肝和痢疾的发病率较高，其发病数均占总病数的10％以上；（5）流动人口疟疾和新生儿破伤风发病率高于当地人群，而其它传染病发病率则低于当地人群。结论：目前，流动人口传染病问题已日益突出，对社会稳定和经济发展将发生严重影响，采取合适的防制措施对控制流动人口传染病是非常迫切和必要的。     

Periodontal conditions among the middle-aged and the elderly in Hong Kong

Abstract The aim of this study was to describe the periodontal conditions in 372 35–44-yr-old and 537 noninstitutionalized 65–74-yr-old Hong Kong Chinese who were examined clinically for loss of attachment, recession, probing depth, calculus, and bleeding after probing. Community Periodontal Index (CPI) data and treatment need indications were compiled from index teeth or their substitutes. The prevalence of loss of attachment varied considerably in both cohorts according to the definition of the threshold (≥6, ≥9, and ≥12 mm, respectively). The mean numbers of teeth with loss of attachment at the ≥6-mm threshold and at higher thresholds were small. In both age cohorts, about one-fifth of subjects had probing depths ≥6-mm, while al the ≥9-mm threshold only 2–3% were so affected. Although recession was an important component of loss of attachment in the younger cohort, in the older cohort the prevalence and extent of recession were greater than for probing depths at thresholds ≥4 mm. All subjects had one or more teeth with calculus, bleeding, or both, most teeth being so affected. Eighty-four of the 537 65–74-yr-old subjects were excluded either because of edentulousness or because extractions indicated for the remaining teeth would have rendered the subjects edentulous. The distribution of subjects according to their highest CPI score was remarkably similar for the two cohorts. No subjects in either age group were assessed as “healthy” (CPI code 0) or had “bleeding only” (code 1) as their highest score. While most subjects scored CPI code 2 or 3 us their highest score, only 17% of the younger and 15% of the older cohort scored Community Periodontal Index of Treatment Needs (CPITN) code 4. Differences in the mean number of sextants affected by CPI codes between the two cohorts were mainly due to a greater number of excluded sextants in the older cohort. CPI findings for 35–44-yr-olds differed little from those reported in 1984.     

浅谈对传染科护士素质的要求与体会

根据笔者在传染科病房工作中的体会,从六个方面针对传染科工作的特殊性和存在的共性分别阐述了传染科护士在工作中如何高标准、严要求自己,如何对病人做到到位的护理,旨在提高传染科病房的整体护理质量,从而把更多的实惠让利于患者。     

Comparative effects of plateletderived growth factor-BB and insulin-like growth factor-I, individually and in combination, on periodontal regeneration in Macaca fascicularis

Platelet-derived growth factor (PDGF) and insulin-like growth factor I (IGF-I) in combination have previously been shown to enhance periodontal regeneration. The objective of this study was to further characterize the biological effects of this combination of growth factors in non-human primates and compare the effects to those of each growth factor individually. Ligature-induced periodontitis was initiated in 10 cynomolgus monkeys. After periodontal lesions were established, surgery was performed, and either a methylcellulose gel vehicle or vehicle containing 10 μg each of either PDGF-BB, IGF-I or both PDGF-BB and IGF-I was applied to exposed root surfaces. Biopsies were taken 4 and 12 wk after treatment and the extent of periodontal regeneration was assessed by histomorphometry. At both 4 and 12 wk vehicle-treated lesions generally revealed minimal osseous defect fill (ODF) (8.5±2.1% and 14.5±5.7%, respectively) and new attachment (NA) (34.1±5.2% and 26.6±10.5%, respectively). IGF-I treatment did not significantly alter healing compared to vehicle in any parameter at both 4 and 12 wk. PDGFBB-treated sites exhibited significant (p<0.05) regeneration of NA (69.6±12.0%) at 12 wk; trends for PDGF-BB treatment effect were also observed in other parameters at 4 and 12 wk. although these increases were not statistically significant. Treatment with PDGF-BB/IGF-I resulted in 21.6±5.1 % and 42.5±8.3% ODF at 4 and 12 wk, respectively, and 64.1±7.7% and 74.6±7.4% NA at 4 and 12 wk, respectively (all significantly greater than vehicle, p<0.05). The results from this study demonstrated that: 1) IGF-1 alone at the dose tested did not significantly alter periodontal wound healing; 2) PDGF-BB alone significantly stimulated NA, with trends of effect on other parameters; and 3) the PDGF-BB/IGF-I combination resulted in significant increases in NA and ODF above vehicle at both 4 and 12 wk.