论中药质量评价模式的创新

目前主要依据现代分析手段诸如IR、LC-MS、NMR等对单一指标成分含量测定或建立指纹图谱以及对化学成分进行定性定量分析的化学表征,以及对药物体内代谢成分谱进行表征评价中药质量。本文从质量的本质内涵入手,认为中药质量应该从化学属性和生物属性两个层次评价。提出了以中医药理论为依据,中药的化学表征和药理效应的生物表征相结合的中药质量评价模式     

小切口复位自锁髓内钉固定配合中药熏洗治疗肱骨干骨折

目的 探讨小切口复位自锁髓内钉固定配合中药熏洗治疗肱骨干骨折的临床效果.方法 2007年9月至2010年5月,对27例肱骨干骨折采用小切口复位自锁髓内钉内固定,术后配合中药熏洗.结果 所有患者经过5~21个月(平均12个月)的随访,骨折均愈合,无内固定物断裂及感染等并发症发生.术后疗效评定优19例,良7例,可1例.结论 小切口复位自锁髓内钉固定配合中药熏洗治疗肱骨干骨折疗效满意,是治疗肱干骨折的一种有效方法.     

古代保健饮品相关名目考

古代保健饮品相关名目较多,大致有“茶”、“茶汤”、“药茶”、“汤”、“熟水”、“渴水”、“饮子”等。考证各名目的内涵,既有相同的方面,又各有不同特殊涵义。其中,“茶汤”一词是指一类以茶与其他植物煎液为主,具有保健治疗作用的饮品,既可以指饮用的茶液,也可以指如茶法服用的汤液。“茶汤”最能体现古代保健饮品的原本意义,也符合现代对于保健饮品的理解,可以较为全面而准确地赅括古代保健饮品的内容。     

妇血宁颗粒的质量标准研究

目的:建立妇血宁颗粒的质量标准。方法:采用薄层色谱(TLC)法对方中三七、断血流进行定性鉴别;采用高效液相色谱法测定三七皂苷R1、人参皂苷Rb1、人参皂苷Rg1的含量。结果:TLC斑点清晰,分离度好,阴性对照无干扰;三七皂苷R1、人参皂苷Rb1、人参皂苷Rg1的进样量分别在0.44～4.40(r=0.9998)、0.82～8.20(r=0.9999)、0.74～7.40(r=0.9997)μg范围内与各自峰面积积分值呈良好线性关系;平均回收率分别为98.21%、98.52%、98.76%,RSD分别为0.81%、0.77%、0.91%(n均为6)。结论:所建标准可用于该制剂的质量控制。     

Hepatoprotective effects of Yi Guan Jian, an herbal medicine, in rats with dimethylnitrosamine-induced liver fibrosis

Aims of the study

Yi Guan Jian (YGJ) has long been employed clinically to treat liver fibrosis in traditional Chinese Medicine but the mechanism underlying the regulation has not been clarified in detail. The present investigation was designed to assess the involvement of the fibrosis pathway in dimethylnitrosamine (DMN)-induced liver fibrosis in rats.

Materials and methods

Liver fibrosis was induced by DMN injection (10 mg/kg, i.p., given three consecutive days each week) following 4 weeks. YGJ was oral administered (1.8 g/kg daily via gastrogavage for two weeks). Liver sample were subjected to histological and western blot studies. For evaluation of hepatic fibrosis-related factors, collagen α1-I, tissue inhibitor of metalloproteinase-1 (TIMP-1), and α-smooth muscle actin (α-SMA) mRNA and protein levels were analyzed.

Results

YGJ remarkably prevented body weight loss and DMN damage in the liver, and it inhibited the elevation of serum glutamate oxaloacetate transaminase (GOT), and glutamic pyruvic transaminase (GPT). Oral administration of YGJ extract significantly reduced the accumulation of collagen α1-I, TIMP-1, and α-SMA in liver tissues.

Conclusions

Taken together, these findings indicate that the YGJ Chinese herb showed hepatoprotective and anti-fibrogenic effects against DMN-induced hepatic injury. Our data suggest that the YGJ may be useful in reversing the development of hepatic fibrosis.     

Reduced SARS-CoV-2 infection risk is associated with the use of Seven-Flavor Herb Tea: A multi-center observational study in Shanghai,China

ObjectiveOmicron, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, is responsible for numerous infections in China. This study investigates the association between the use of Seven-Flavor Herb Tea (SFHT) and the risk of SARS-CoV-2 infection to develop precise and differentiated strategies for control of the coronavirus disease 2019 (COVID-19).MethodsThis case-control study was conducted at shelter hospitals and quarantine hotels in China. A total of 5348 laboratory-confirmed COVID-19 patients were enrolled between April 1 and May 31, 2022, while 2190 uninfected individuals served as healthy controls. Structured questionnaires were used to collect data on demographics, underlying diseases, vaccination status, and use of SFHT. Patients were propensity-score-matched using 1:1 nearest-neighbor matching of the logit of the propensity score. Subsequently, a conditional logistic regression model was used for data analysis.ResultsOverall, 7538 eligible subjects were recruited, with an average age of [45.54 ± 16.94] years. The age of COVID-19 patients was significantly higher than that of uninfected individuals ([48.25 ± 17.48] years vs [38.92 ± 13.41] years; t = 22.437, P < 0.001). A total of 2190 COVID-19 cases were matched with uninfected individuals at a 1:1 ratio. The use of SFHT (odds ratio = 0.753, 95% confidence interval: 0.692, 0.820) was associated with a lower risk of SARS-CoV-2 infection compared to untreated individuals.ConclusionOur findings suggest that taking SFHT reduces the risk of SARS-CoV-2 infection. This is a useful study in the larger picture of COVID-19 management, but data from large-sample multi-center, randomized clinical trial are warranted to confirm the finding.Please cite this article as: Zhang SX, Chen XX, Zheng Y, Cai BH, Shi W, Ru M, Li H, Zhang DD, Tian Y, Chen YL. Reduced SARS-CoV-2 infection risk is associated with the use of Seven-Flavor Herb Tea: A multi-center observational study in Shanghai, China. J Integr Med. 2023; 21(4):369–376.     

A systematic review of the efficacy and safety of Rosa damascena Mill. with an overview on its phytopharmacological properties

Rosa damascena Mill. is one of the most famous ornamental plants cultivated all over the world mostly for perfumery industries. Traditionally it has been used as an astringent, analgesic, cardiac and intestinal tonic.The paucity ofauthoritative monographs urged usto summarize its clinical effectiveness and safety with acomprehensive review of the literature.“PUBMED”, “SCOPUS”, “WEBOF SCIENCE” were searched up to April 30, 2017 with search terms:(“Rosa damascena” OR “Damask Rose”). All human studies with any mono-preparation were included. In vitro and animal studies from “PUBMED”were also reviewed and outlined.Of “1000” identified publications, twelveeligibleclinical trials were retrieved. Antimicrobial, anti-inflammatory, antioxidant, anticancer, protective neuronal, cardiac, gastrointestinal and hepatic effectsin 30 in vitro and 21 animal studies were also shown. there are promising evidences for the effectiveness and safety of Rosa damascena Mill in pain relief, but confirmatory studies withstandardized products is suggested.     

挥发油提取过程动力学模型及其参数的确定

目的：探讨中药材挥发油提取过程的动力学模型及其参数。方法：将挥发油的提取过程模拟为人体静注给药经肾脏的消除过程，并采用亏量法和速率法求解其动力学方程。结果：中药材挥发油提取过程的动力学模型为：Vt=Vt^m(I-e^kt),ln(Vt^∞-Vt)=-kt lnVt^∞,lnΔVt/Δt=-ktc lnkeVt.结论：该动力学模型与挥发油实际提取过程相似，可有效指导工业生产。     

痔瘘洗必灵袋泡剂治疗血栓外痔30例

目的:观察痔瘘洗必灵袋泡剂熏洗坐浴治疗血栓外痔的临床疗效。方法:将58例血栓外痔患者随机分为治疗组30例和对照组28例,治疗组给予痔瘘洗必灵袋泡剂熏洗坐浴治疗,对照组给予1:5 000高锰酸钾熏洗坐浴治疗。结果:治疗后,治疗组疼痛评分优于对照组,差异均有统计学意义(P0.05);治疗组有效率96.7%,对照组有效率78.6%,治疗组明显优于对照组(P0.05)。结论:痔瘘洗必灵袋泡剂熏洗坐浴治疗血栓外痔有明显疗效。     

小儿再障中西医结合治疗前后VEGF的表达及意义

目的:研究小儿再障中西医结合治疗效果及治疗前后血管内皮生长因子的变化。方法:32例年龄在1岁～14岁的小儿再障患者,应用中西医结合治疗,按全国统一标准评定疗效,同时观察血清血管内皮生长因子浓度的变化,检测方法为ELISA法。结果:小儿再障经过中西医结合治疗后,总有效率达到78.1%,血清血管内皮生长因子水平逐渐增长,结果具有统计学意义(P<0.05)。结论:小儿再障通过中西医结合治疗效果明显,血管内皮生长因子也逐渐增高。