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91.
目的 对多激素分泌性垂体泌乳素腺瘤的克隆状态以及激素分泌谱进行分析。方法 对26例女性垂体泌乳素腺瘤患者(单激素分泌性PRL腺瘤7例,多激素分泌性PRL腺瘤19例)进行肿瘤标本的免疫组化分析,并且提取DNA行HUMARA分析。结果免疫组化分析提示本组多激素分泌性垂体PRL腺瘤具有10种不同的激素分泌谱,现代分子生物学HUMARA克隆分析提示11/13例(85%)多激素分泌性垂体PRL腺瘤为单克隆起源。结论 结果提示垂体泌乳素腺瘤除了分泌泌乳素外,还可以分泌多种垂体激素,而且绝大多数多激素分泌性垂体腺瘤的起源是单克隆性的。 相似文献
92.
目的研究抑制素(INH)在体条件下能否通过大鼠的血脑屏障及在垂体或下丘脑的分布。方法采用颈静脉灌流和放射自显影技术,将20只SD大鼠分为4组,每组5只,第1~3组(实验组)颈静脉注射^125 I-INH50μl,第4(对照)组注射等量的生理盐水。第1,2,3组分别于注射后30,60和120min断头处死,取出垂体、下丘脑,以生理盐水洗涤,测量放射性计数,取放射性最大组的垂体与下丘脑组织行放射自显影分析。结果第1组垂体的放射性最高[(1008.00±5.78)Bq],而第2和3组分别为(723.00±4.95)和(491.00±4.90)Bq;1~3组的下丘脑放射性分别为(20.00±1.01),(22.00±0.95)与(19.00±0.73)Bq。第4组垂体与下丘脑的放射性分别为(16.00±1.40),(15.00±0.98)Bq。各实验组大鼠垂体的放射性与对照组差异有统计学意义(P〈0.01),且在注射后30min放射性最大(第1组),60和120min后逐渐降低;而实验组与对照组大鼠的下丘脑放射性差异无统计学意义(P〉0.05);放射自显影结果示,实验组大鼠的垂体组织上有明显的银颗粒,而对照组没有;实验组和对照组大鼠的下丘脑组织上均未见明显的银颗粒。结论^125I-INH能通过大鼠血脑屏障,垂体在注射后30min放射性最大,在大鼠垂体上有INH结合位点或受体,而在其下丘脑没有。 相似文献
93.
Sunil Kumar Saxena S. Gopalakrishnan 《Indian journal of otolaryngology and head and neck surgery》2003,55(4):281-282
Despite the common occurrence of pleomorphic adenoma of major salivary glands, intranasal pleomorphic adenoma are rare. We
present a ease of pleomorphic adenoma of the nasal septum along with a brief review of literature. The histological nature
of this lesion in comparison to other salivary gland tumours and the importance of an accurate diagnosis has been stressed. 相似文献
94.
Branislava Milenkovi? Jelena Stojsi? Dragan Mandari? Ruza Stevi? 《The Journal of asthma》2007,44(9):789-793
We report a case of mucous gland adenoma arising in the left main bronchus which was initially misdiagnosed as asthma and review the previous reported cases of this rare tumor published in the available literature. 相似文献
95.
96.
Chronic renal failure and its treatment in tuberous sclerosis 总被引:2,自引:0,他引:2
BACKGROUND.: Chronic renal failure is rare in tuberous sclerosis, but itsprecise frequency is not known and treatment modalities havenot been evaluated. METHODS.: A questionnaire was addressed to the 260 French dialysis centresand the characteristics of 65 patients with tuberous sclerosisand chronic renal failure were analysed. RESULTS.: In France the approximate prevalence of tuberous sclerosis withend-stage renal failure is 0.7 cases per million and that ofend-stage renal failure in tuberous sclerosis 1 per 100. Tuberoussclerosis with chronic renal failure was more frequent in females(63.1%) and was diagnosed at a mean age of 29 years. Renal impairmentwas the first manifestation of tuberous sclerosis in about halfthe cases. Renal tumours were frequent, with angiomyolipomasin 15 cases (23.1%), cysts in 12 cases (18.5%), and both in35 cases (53.8%). Malignancies were associated in nine cases(13.8%). Nephrectomy was done before dialysis in 21 cases (32.3%),and after the start of dialysis in six cases (9.2%). All butone of the 48 patients with end-stage renal failure were treatedby dialysis; 20 were transplanted, with good results. CONCLUSIONS.: Tuberous sclerosis with end-stage renal failure is rare. Thesepatients require dialysis and renal transplantation, but werecommend binephrectomy after starting dialysis and before transplantation,given the risk of cancer and bleeding related to angiomyolipomas. 相似文献
97.
Primary leiomyosarcoma of the thyroid gland 总被引:1,自引:0,他引:1
Osamu Ozaki Kiminori Sugino Takashi Mimura Kunihiko Ito Seiichi Tamai Yasuhiro Hosoda 《Surgery today》1997,27(2):177-180
Primary leiomyosarcoma of the thyroid gland is extremely rare, and to the best of our knowledge only five well-documented
cases have been reported in the world literature. We herein report a 58-year-old female patient with primary leiomyosarcoma
of the thyroid who was successfully treated by total thyroidectomy with a modified neck dissection. Immunohistochemically,
the tumor cells showed positive reactivity to α-smooth muscle actin and vimentin. Radical surgery was thus considered to be
essential in the treatment of this rare but rather aggressive malignancy. 相似文献
98.
99.
Fanasy P. Deming Ibtisam Al-Hashimi Nasser Haghighat William W. Hallmon David G. Kerns Celeste Abraham Francisco Rivera-Hidalgo 《Journal of oral pathology & medicine》2007,36(3):132-135
Background: Reduction in salivary secretion is the hallmark of Sjögren's syndrome (SS). Calmodulin (CaM) and calmodulin binding proteins (CaMBPs) play a key role in the secretory process of saliva. Recent studies have suggested that SS‐B, an autoantibody associated with SS, is a CaMBP. This finding suggests that CaMBP may contribute to the loss of saliva in SS. To better understand the role(s) of these proteins in SS, the purpose of this study was to compare salivary CaMBPs in Sjögren's patients and controls. Methods: Saliva samples were collected from 20 patients and 20 age‐, race‐, and gender‐matched controls. CaM overlay was used to identify CaMBPs in saliva of patients and controls. Results: Higher number of salivary CaMBPs was observed among patients than controls. Conclusions: The increased number of salivary CaMBPs in SS may suggest a potential role for these proteins in the pathogenesis of the disease. 相似文献
100.
Adenoma malignum (minimal deviation adenocarcinoma) of the cervix responsive to hormonal treatment 总被引:1,自引:0,他引:1
Adenoma malignum (AM) is a rare variant of cervical adenocarcinoma with an unfavorable prognosis despite radiation therapy, surgery, or chemotherapy either alone or in combination. Hitherto, however, the effectiveness of hormonal therapy for this condition has not been evaluated. We report on a patient with cervical AM treated with progesterone before surgery. The progesterone therapy resulted in a complete clinical response and partial surgical response. Later on the treatment was changed to tamoxifen because of side effects of the progesterone treatment. The patient is still without evidence of disease 42 months after the start of the hormonal therapy. The progesterone receptor analysis on the biopsy was clearly positive. This is, to our knowledge, the first case of an AM responsive to hormonal treatment. Furthermore, this is the first case of an AM with bone metastases at the time of primary diagnosis. 相似文献