光疗前后新生儿的DNA指纹分析

目的：了解光疗对新生儿的ＤＮＡ是否有损伤。方法：采用ＬＥ１１．８小卫星探针，经Ｓｏｕｔｈｅｒｎ印迹法检测接受光疗前后新生儿外周血的ＤＮＡ指纹谱带。结果：２２例接受光疗前后的新生儿ＤＮＡ指纹相比，均未见到任何谱带的改变。结论：光疗未引起新生儿的ＤＮＡ损伤，应用国产蓝光治疗器对高胆红素血症新生儿在４８ｈ内治疗是安全的。     

根面残留牙周组织对延迟再植牙愈合的影响

目的：观察牙根面残留牙周组织对延迟再植牙愈合的影响。方法：选用两只成年猕猴，以右下第二双尖牙为实验组，左侧同名牙为对照组，牙齿拔除后行延迟再植术。实验组牙齿术前刮除根面残留的牙周组织。术后４周、８周采取标本进行组织病理学观察和图像处理分析。结果：实验组牙根吸收率较对照组为低（Ｐ＜０．０５）。结论：刮除延迟再植牙根面的坏死牙周组织能改善预后。     

原发性高血压病患者血浆神经肽Y浓度的改变及其性别差异

用放射免疫分析方法测定原发性高血压病患者与健康志愿者在平板运动试验前后的血浆神经肽Ｙ（ＮＰＹ）浓度。结果显示，男性患者运动前显著高于对照组（１４５±６与１２８±５ｐｇ／ｍｌ，ｐ＜０．０５），运动后无显著改变；女性患者在运动前与对照组无显著差别（１２４±６与１３２±７ｐｇ／ｍｌ），运动后与男、女对照组均升高。     

女性不育症生殖道沙眼衣原体感染的研究

应用直接免疫荧光技术，对１８７例不育妇女和１２６例正常育龄妇女的宫颈沙眼衣原体感染进行了检测，结果表明，不育妇女宫颈衣原体的感染率为２０．３％，明显高于对照组的６．３％；在２０～２４岁年龄组感染率最高，为３０．０％。伴有宫颈糜烂者较无糜烂者偏高，原发不育和继发不育比较无差异。     

Purification of an onco-fetal antigen from mammary carcinoma cells

Summary Mammary carcinoma cell membranes were solubilized by a zwitterionic detergent, 3-(3-cholamidopropyl)-dimethyl-ammonio)-propanesulfonate (CHAPS). The solubilized membrane components were resolved by high pressure liquid chromatography (HPLC) using a styrogel protein column. One of the fractions was found to react specifically with anti-F9-antiserum in a solid-phase immunosorbent assay. Following recycling this fraction was purified to homogeneity and had an N-terminal amino acid residue of lysine. Its molecular weight was estimated to be 15,000 daltons.No comparable fraction could be detected in the solubilized membrane components of nonmalignant mammary tissue.     

大鼠血管中a_1－肾上腺素受体不同亚型的减敏差异

目的：观察α＿１－ＡＲ的减敏过程及其亚型差异。方法：给清醒大鼠持续输注苯肾上腺素（ＰＥ）及离体主动脉和肾动脉用去甲肾上腺素（ＮＥ），持续温育后，测定血压或进行血管收缩功能实验。结果：持续输注ＰＥ后，由ＰＥ介导的升压作用较对照组明显降低，升高相同血压所需的ＰＥ剂量显著增加；离体血管经不同时间和不同浓度的ＮＥ预温育后，α＿１－ＡＲ介导的血管收缩－效应曲线（ＣＲＣ）显著右移，但含α＿（１Ｄ）－ＡＲ的主动脉的右移程度均显著大于含。α＿（１Ａ）－ＡＲ的肾动脉。结论：α＿１－ＡＲ在激动剂持续作用下可产生减敏，且α＿（１Ｄ）－ＡＲ远较α＿（１Ａ）－ＡＲ容易发生。     

枸杞多糖对小鼠胸腺细胞凋亡的调节

目的：以ＤＥＸ诱导小鼠胸腺细胞凋亡为模型，研究中药枸杞多糖（ＬｙｃｉｕｍＢａｒｂａｒｕｍＰｏｌｙｄｓｃ－ｃｈａｒｉｄｅ．ＬＢＰ）及氧化苦参碱（ＯＸＹ）对胸腺细胞凋亡的调节作用。方法：应用ＰＩ法检测亚２倍体细胞，二苯胺法测定胸腺细胞ＤＮＡ片断化％及ＤＮＡ凝胶电泳。结果：ＬＢＰ可抑制ＤＥＸ诱导的ＤＮＡ片断化，其抑制作用具有剂量依赖性，以１ｇ／Ｌ最明显；ＬＢＰ（ｌｇ／Ｌ）尚可阻止ＤＥＸ诱导的胸腺细胞内Ｃａ￣（２＋）升高。结论：ＬＢＰ可抑制ＤＥＸ诱导的小鼠胸腺细胞凋亡，ＯＸＹ对此无明显的调节作用。     

汉语阅读困难儿童脑电功率分析

目的：探讨阅读困难儿童脑电图的特征性标志。方法：对阅读困难儿童在安静状态下的脑电绝对功率进行分析。结果：在某些脑区，阅读困难儿童的脑波各频段均较对照组减少。结论：阅读困难儿童可能存在脑觉醒程度过高，各脑区脑电发育与同龄儿童有差异。     

顺铂壳聚糖微球肝动脉栓塞化疗的动物实验和治疗肝癌的临床研究

报道用国内首次研制的顺铂壳聚糖微球做的犬肝动脉栓塞化疗的实验和治疗肝癌的初步临床应用结果。顺铂壳聚糖微球能引起栓塞动脉分支减少，动物肝和病人肝癌组织坏死和出血，栓塞动脉直径为１００～５００μｍ，微球在动脉内有碎裂，病人对此微球的耐受性好。     

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

The glandular odontogenic cyst (GOC) is now a relatively well-known entity with recent reviews indicating over 100 cases reported in the English literature. The GOC’s importance relates to the fact that it exhibits a propensity for recurrence similar to the odontogenic keratocyst, and that it may be confused microscopically with central mucoepidermoid carcinoma (CMEC). Numerous histopathologic features for the GOC have been described, but the exact microscopic criteria necessary for diagnosis have not been universally accepted. Furthermore, some of the microscopic features of GOC may also be found in dentigerous, botryoid, radicular, and surgical ciliated cysts. The purpose of this multicenter retrospective study is to further define the clinical, radiographic, and microscopic features of GOC, to determine which microscopic features may be helpful for diagnosis in problematic cases, to determine the most appropriate treatment, and to determine if GOC and CMEC share a histopathologic spectrum. In our series of 46 cases, the mean age at diagnosis was 51 years with 71% of cases in the 5th–7th decades. No gender predilection was noted. 80% of cases occurred in the mandible, and 60% of the lesions involved the anterior regions of the jaws. Swelling/expansion was the most common presenting complaint, although some cases were asymptomatic. Radiographically, most cases presented as a well-defined unilocular or multilocular radiolucency involving the periapical area of multiple teeth. Some lesions displayed a scalloped border. Cases also presented in dentigerous, lateral periodontal, and “globulomaxillary” relationships. The canine area was a common location for maxillary cases. All cases were treated conservatively (enucleation, curettage, cystectomy, excision). Follow-up on 18 cases revealed a recurrence rate of 50% (9/18), with 6 cases recurring more than once (range of follow-up: 2 months to 20 years; average length of follow-up: 8.75 years). The mean interval from initial treatment to first recurrence was 8 years, and from first recurrence to second recurrence was 5.8 years. Two cases recurred three times and the interval from second to third recurrence was 7 years (exact interval only documented in one case). All cases exhibited eosinophilic cuboidal (hobnail) cells, a feature not specific for GOC, but necessary for diagnosis, in our opinion. Univariate analysis indicated several features that are most helpful in distinguishing GOC from GOC mimickers in problematic cases, including: (1) the presence of microcysts (P < 0.0001); (2) epithelial spheres (P < 0.0001); (3) clear cells (P = 0.0002); (4) variable thickness of the epithelial cyst lining (P = 0.0002); and (5) multiple compartments (P = 0.006). Stratified analysis indicated that when microcysts are present, epithelial spheres and multiple compartments are still significant, and clear cells are marginally significant in distinguishing GOCs from GOC mimickers. The presence of microcysts (P = 0.001), clear cells (P = 0.032), and epithelial spheres (P = 0.042) appeared to be most helpful in distinguishing GOC associated with an unerupted tooth from dentigerous cyst with metaplastic changes. There were no statistically significant differences microscopically between GOCs that recurred and those that did not. The presence of 7 or more microscopic parameters was highly predictive of a diagnosis of GOC in our series (P < 0.0001), while the presence of 5 or less microscopic parameters was highly predictive of a non-GOC diagnosis (P < 0.0001). Islands resembling mucoepidermoid carcinoma (MEC-like islands) were identified in the cyst wall of three cases, only one of which had follow-up (no evidence of disease at 74 mo.); therefore, at this time insufficient information is available to determine whether GOC and CMEC share a histopathologic spectrum or whether MEC-like islands in GOCs are associated with more aggressive or malignant behavior.