小型高精度近红外线成像乳腺癌检测仪的研制开发

近年来我国乳腺癌发病率逐年上升,提早检测乳腺癌是非常必要和有效的防范措施,本文介绍了此种新型检测仪的设计思想和结构特点。本检测仪扩大了检测范围以适应不同检测对象的检测要求,而且提高了近红外线成像的检测精度。实验证明本检测仪具有检测安全、操作简易、重复性好等优点。     

Simultaneous determination of Maillard reaction impurities in memantine tablets using HPLC with charged aerosol detector

A gradient high performance liquid chromatographic (HPLC) method using charged aerosol detection (CAD) was developed for the simultaneous determination of impurities formed by the Maillard reaction in memantine tablets. These impurities were a memantine-lactose adduct (ML), a memantine-dimethylamino glycine adduct (DMAG), a memantine-galactose adduct (MGAL), and a memantine-glucose adduct (MGLU). The chromatographic separation was performed on a Synergy Hydro RP column (100 mm × 3 mm, 2.5 μm particles) from Phenomenex with gradient elution using mobile phases consisting of 0.6% (v/v) of heptafluorobuturic acid (HFBA) in two acetonitrile-isopropyl alcohol-water mixtures. The method validation for the impurities included linearity, accuracy by spike recovery, precision, limits of detection and quantitation, and robustness. The method was sensitive for these non-chromophoric impurities down to 0.4-0.6 μg/mL (0.02-0.03% of the memantine drug substance). The effect of mobile phase HFBA concentration on chromatographic resolution and peak shape was investigated, and the effect of sample diluent acidification on method accuracy via spike recovery was studied. The operational simplicity of the CAD detector for routine quality control has been demonstrated.     

基于溴化镧探测器的γ射线空气吸收剂量率的测量方法

目的 针对溴化镧闪烁体探测器,开展了G(E)函数的计算方法研究,最终实现了空气吸收剂量率的测量.方法 首先,基于蒙特卡罗模拟计算方法,模拟计算出溴化镧探测器的γ能谱,给出不同能量的响应函数;然后,利用最小二乘法计算得到了G(E)函数;最后,利用标准点源实验,将溴化镧探测器利用G(E)函数转换测量得到的空气吸收剂量率与理...     

64排螺旋CT肝动脉血管成像的临床初步研究

目的探讨64排螺旋CT血管成像对肝动脉正常解剖和变异的显示及临床指导价值。资料与方法选择60例肝脏占位性病变患者行肝动脉64排螺旋CT血管成像,所有图像均以最小层厚0.67mm、间隔0.33mm重组传送到工作站。采用最大密度投影(MIP)和容积再现(VR)两种方法进行后处理,以Michels分型观察肝动脉的解剖与变异类型。结果正常肝动脉解剖共36例;肝动脉起源变异24例。其中属于Michels分型的有4种共17例,最多的是MichelsⅡ型7例,其次为Ⅲ型4例;Ⅴ型和Ⅸ型各3例。未被列入Michels分型的其他类型共7例(11.7%)。以DSA或手术为对照的26例中,CT血管成像对肝动脉解剖及变异的诊断符合率为100%。结论64排螺旋CT肝动脉血管成像能够准确地证实肝动脉解剖与变异,并能明确肿瘤血管异位侧支来源,为临床手术、介入治疗及肝移植等提供更多信息。     

数字化放射医学影像技术

本文讲述了数字化X射线摄影的分类，X射线探测器的发展状况，并通过传统X射线摄影与数字X射线摄影的对比，阐述了放射医学影像数字化发展的必然道路。     

液相色谱流出峰定量法研究Ⅱ.流出峰与检测峰的数学关系

从记录仪中得出的检测峰不是真实的色谱峰,而是流出峰在流通池内受检测过程影响后所得出的。本文推导了检测峰与流出峰的数学关系,指出检测峰是流出曲线与检测器特性函数(DCF)的卷积,可用快速富里叶变换或专门程序由检测峰得出流出峰,这有利于进行理论研究并可在此基础上建立两种快速的定量法——紫外分光吸收系数法和流出峰法。本文首次提出检测器特性函数的概念。     

AA鸡体内含硒量的试验

从先后饲养45d龄的3群AA鸡中各选择10羽,每羽体重约2kg,公母各半,口腔投人~(75)Seo_2 4 μci/羽,常规饲养24h,屠宰分别取其肌肉、心、肝、毛和粪便各1g,采用“ET-613自动计数~(125)I放免测量仪”测量~(75)Seo_2在鸡体内肌肉、心、肝、毛中的分布和在粪便中~(75)Seo_2的含量。按4μci/羽剂量的放射性~(75)Seo_2引入鸡体内,测量结果,经24h,在肝脏含量最多,而肌肉最少。用放射性~(75)Seo_2制剂,由4μci/羽至8μci/羽的范围内引入量,随着剂量增加所测器官放射性~(75)Seo_2无明显增加,而粪便的放射性~(75)Seo_2则随引入放射性~(75)Seo_2课题的增加而增加。     

Atypical Visual Orienting to Gaze- and Arrow-Cues in Adults with High Functioning Autism

The present study investigates visual orienting to directional cues (arrow or eyes) in adults with high functioning autism (n = 19) and age matched controls (n = 19). A choice reaction time paradigm is used in which eye- or arrow direction correctly (congruent) or incorrectly (incongruent) cues target location. In typically developing participants, the visual orienting reflex is longer for eyes than for arrows. Right side cueing, but not left side cueing, induced a congruence effect for eyes, while this effect was evident for right as well as for left side arrow cues. In participants with autism the overall visual orienting reflex was not different between arrows and eyes and no laterality effect was found for eyes cueing. These findings suggest that, instead of a specific Eye Direction Detector persons with autism might have a general ‘Symbol Direction Detector’.     

无创心血管功能参数检测仪的研制

该研究基于光电容积脉搏波描记术(PPG)和nRF52832微控制器,设计了一种无创心血管功能参数检测仪,其具有使用方便、实时无创检测、低功耗等特点,实现了PPG信号采集、心血管功能参数计算等功能,不仅可应用于临床,更适用于社区及家庭。现主要介绍该检测仪的整体框架方案、硬件设计、算法软件设计。     

用非介入法检测诊断X射线机的管电压和曝光时间

目的 检测诊断X射线机的管电压和曝光时间。方法 采用CsI/光电二极管和单片机技术。结果 研制了一种非介入式kVp计。结论 利用此kVp计可一次曝光立刻得到管电压和曝光时间等信息。