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21.
用20只Wistar大鼠以PHA—L免疫组织化学顺行追踪技术研究了下丘脑室旁核及其邻近区域对脑室系统室管膜的传出联系。在脑室系统某些部位的室管膜层或其下方见有丰富的标记纤维并见许多膨结和终末膨突。这些纤维似乎参与形成室管膜上、下丛,构成脑—脑脊液神经体液回路的重要环节。 相似文献
22.
久泻宁动物毒性试验研究 总被引:1,自引:0,他引:1
目的 (1)观察久泻宁一日内小鼠灌胃1~3次后的毒性反应和死亡情况,测定最大耐受量;(2)观察久泻宁给大鼠连续灌胃3个月,对机体产生的毒性反应、严重程度及可逆性,确定无毒剂量。为人拟用量提供参考。方法 (1)久泻宁小鼠灌胃,一日2~3次,观察急性毒性反应.测定最大耐受量;(2)久泻宁高、中、低三个剂量组和一个对照组,大鼠连续灌胃3个月,观察外观行为和体质量变化。试验期结束。每组取1/2动物活杀。检测血常规、血液生化、病理组织;1/2动物停药进行3周的恢复期观察后。同法检测上述指标。结果 久泻宁小鼠灌胃给药的最大耐受药量为750g/kg(含生药)。相当临床日拟用量(2.5g/kg)的300倍;大鼠连续3个月灌胃给药的无毒剂量为125g/kg(含生药).相当临床拟用量50倍。结论 久泻宁无明显毒性,安全范围大。临床日拟用量2.5g/kg、疗程1个月是安全的。 相似文献
23.
六味地黄汤对实验性糖尿病大鼠心、肝、肾组织中过氧化氢酶活性和过氧化脂质含量的影响 总被引:7,自引:0,他引:7
用四氧嘧啶诱导雄性Wistar大鼠为模型进行研究.结果发现,四氧嘧啶大鼠血糖明显升高,且心、肝、肾组织中过氧化氢酶活性较正常组明显降低,过氧化脂质含量在心、肝组织中明显增高,过氧化脂质与过氧化氢酶比值在心、肝、肾组织中均明显高于正常组,表明糖尿病状态下大鼠心、肝、肾组织中均自由基生成增多,氧化损伤加重.经六味地黄汤治疗后,血糖明显下降,但心、肝、肾组织中的过氧化氢酶活性无改变;而心肌中过氧化脂质含量和过氧化脂质与过氧化氢酶比值则明显降低,过氧化脂质含量和过氧化脂质与过氧化氢酶比值在肝、肾组织中无变化,表明六味地黄汤能明显清除心肌中自由基,抑制心肌中脂质过氧化,且此作用并不是通过提高过氧化氢酶活性来达到. 相似文献
24.
刺激视上核对大鼠痛阈及电针镇痛的影响 总被引:2,自引:1,他引:1
以钾离子透引起的大鼠甩尾反应为痛指标,观察了电和化学刺激视上核(SON)对大鼠痛阈(PT)和电针(EA)镇痛的影响。电刺激SON后,PT明显高于假刺激组(P<0.05~0.001),电刺激SON后电针足三里,镇痛效应明显提高,并有明显的量效关系。电刺激SON的近旁部位(0.5—1mm)对PT及电针镇痛无明显影响。SON内注射L-谷氨酸(L-Glu)后痛阈和电针镇痛效应都明显对照组,也有明显的量效关 相似文献
25.
Age-related Changes in Excitability and Recurrent Inhibition in the Rat CA1 Hippocampal Region 总被引:1,自引:0,他引:1
Costas Papatheodoropoulos George Kostopoulos 《The European journal of neuroscience》1996,8(3):510-520
In hippocampal slices from male Wistar rats aged 1–34 months, we recorded the synaptic field potential responses of the CA1 neurons to stimulation of Schaffer collaterals. Eight electrophysiological indexes were extracted from input/output curves and compared in 11 age groups from 1 to 30 months. Neuronal excitability presented a U-shaped curve of development with a minimum at ˜7–8 months of age. There was a significant continuous increase in neuronal excitability, i.e. a decrease in excitatory postsynaptic potential (EPSP) producing both the threshold and half-maximal population spike from middle age (8–10 months) to senescence (30 months). Synaptic efficiency also increased in old rats to reach a maximum during senescence, i.e. both the current for threshold EPSP and that for half-maximal EPSP reached a minimum in senescence, although the earlier developmental patterns of these two indexes were non-linear. The duration of the field EPSP elicited with maximal stimulation presented an abrupt decay after the first month. Aged animals presented a relatively small maximal population spike. Recurrent inhibition was most prominent on neuronal excitability rather than synaptic strength. Measured as the percentage change in the half-maximal EPSP and half-maximal population spike, recurrent inhibition was found to decrease during the first 7–10 months of life and remained small in later development. 相似文献
26.
作者选择乙基纤维素、聚乙烯醇等高分子材料制成涂膜剂,用大鼠皮进行双氯灭痛药膜的体外透皮速率测定。结果表明,氮酮与丙二醇可以促进药物渗透。不同的高分子材料可影响药物的扩散与释放,从而影响其透皮速率。与无膜无促透剂处方相比,药物在乙基纤维素中的透皮速率没有增加,在聚乙烯醇膜中的透皮速率有显著增加。 相似文献
27.
Kazushi Tsuda Keizo Kimura Hiroki Shima Ichiro Nishio Yoshiaki Masuyama 《Clinical and experimental pharmacology & physiology》1992,19(7):531-535
The present study was designed to investigate the presynaptic alpha 2-adrenoceptor function to inhibit norepinephrine (NE) release in blood vessels of reduced renal mass salt hypertensive rats (Na-loaded HT). Isolated perfused mesenteric vasculatures were prepared from Na-loaded HT and normotensive control rats (NT-control), and the NE release and vascular responsiveness were examined. Periarterial nerve stimulation caused a significantly greater release of NE and pressor responses in Na-loaded HT than in NT-control. Yohimbine, a potent alpha 2-adrenoceptor antagonist, demonstrated the facilitatory effects on NE release during nerve stimulation. The effects were significantly attenuated in Na-loaded HT compared with NT-control. These results demonstrate that vascular sympathetic nervous activity might be enhanced in Na-loaded HT. Furthermore, the increased NE release from vascular adrenergic neurons in Na-loaded HT could partially depend on impaired presynaptic alpha 2-adrenoceptor-mediated modulation, which might contribute to the pathogenesis and maintenance of this form of salt-dependent hypertension. 相似文献
28.
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30.
Thrombin Inhibition in discordant xenograft rejection 总被引:1,自引:0,他引:1
Beth-Ann Lesnikoski Daniel Candinas Ichiro Otsu Rainer Metternich Fritz H. Bach Simon C. Robson 《Xenotransplantation》1997,4(3):140-146
Abstract: Microvascular thrombosis and the associated platelet and endothelial cell activation are prominent observations in xenograft rejection. This pathological picture could be related to the excessive generation of thrombin in the context of either inflammation or putative inter-species molecular incompatibilities between activated coagulation factors and their natural anticoagulants. Relatively selective thrombin Inhibition with the serine protease inhibitor SDZ MTH 958 (MTH-958) are independent of heparinoids and anti-thrombin III. MTH-958 has been shown to significantly prolong porcine cardiac function during perfusion with human blood in an ex vivo model. The aim of this study was to validate the role of thrombin generation in a rodent model of discordant xenograft rejection in vivo. The effect of thrombin inhibition with MTH-958 was tested in both hyperacute rejection (HAR) and delayed xenograft rejection (DXR) after decomplementation with cobra venom factor (CVF) in normal Lewis (Lew) rats and Intrinsic C6 deficiency In PVG (C6-/PVG) recipient rats. Recipient rats received heterotopic guinea pig cardiac xenografts and were treated with titrated doses of MTH-958 until the time of graft rejection. Plasma samples at selected time points were examined to confirm effective thrombin inhibition, and rejected grafts were analyzed by immunohistology. MTH-958 significantly improved graft survival in HAR albeit the extent of prolongation was not marked, but the agent failed to prolong survival In CVF-treated Lew rats. In C6-/PVG rats receiving MTH-958, a significantly reduced graft survival time was observed when compared with C6-/PVG controls. The grafts from MTH-958-treated animals showed dense deposits of C3, IgM, and IgG with fibrin levels similar to controls. The thrombin antagonist tested could prolong xenograft survival during HAR but had no benefit in DXR. The relative non-specificity of the serine protease inhibitor MTH-958 with the potential activation of alternative pathway of complement via the inhibition of factor I could account for the failure to prolong xenograft survival in DXR. The pathogenetic significance of thrombin generation in this situation remains to be determined by the use of more selective and pharmacologically acceptable I anti-thrombin agents. 相似文献