全文获取类型
收费全文 | 20157篇 |
免费 | 1781篇 |
国内免费 | 551篇 |
专业分类
耳鼻咽喉 | 398篇 |
儿科学 | 179篇 |
妇产科学 | 521篇 |
基础医学 | 3315篇 |
口腔科学 | 165篇 |
临床医学 | 2617篇 |
内科学 | 1272篇 |
皮肤病学 | 91篇 |
神经病学 | 7851篇 |
特种医学 | 359篇 |
外科学 | 2362篇 |
综合类 | 1272篇 |
预防医学 | 420篇 |
眼科学 | 172篇 |
药学 | 1001篇 |
3篇 | |
中国医学 | 401篇 |
肿瘤学 | 90篇 |
出版年
2024年 | 76篇 |
2023年 | 428篇 |
2022年 | 696篇 |
2021年 | 955篇 |
2020年 | 960篇 |
2019年 | 788篇 |
2018年 | 787篇 |
2017年 | 760篇 |
2016年 | 608篇 |
2015年 | 608篇 |
2014年 | 1114篇 |
2013年 | 1215篇 |
2012年 | 881篇 |
2011年 | 1038篇 |
2010年 | 828篇 |
2009年 | 826篇 |
2008年 | 912篇 |
2007年 | 837篇 |
2006年 | 803篇 |
2005年 | 659篇 |
2004年 | 567篇 |
2003年 | 563篇 |
2002年 | 487篇 |
2001年 | 385篇 |
2000年 | 343篇 |
1999年 | 318篇 |
1998年 | 285篇 |
1997年 | 247篇 |
1996年 | 222篇 |
1995年 | 219篇 |
1994年 | 227篇 |
1993年 | 160篇 |
1992年 | 217篇 |
1991年 | 179篇 |
1990年 | 181篇 |
1989年 | 166篇 |
1988年 | 135篇 |
1987年 | 130篇 |
1986年 | 129篇 |
1985年 | 207篇 |
1984年 | 184篇 |
1983年 | 140篇 |
1982年 | 146篇 |
1981年 | 137篇 |
1980年 | 134篇 |
1979年 | 122篇 |
1978年 | 98篇 |
1977年 | 78篇 |
1976年 | 79篇 |
1974年 | 50篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
32.
33.
34.
《Brain stimulation》2020,13(6):1668-1677
BackgroundEndovascular delivery of current using ‘stentrodes’ – electrode bearing stents – constitutes a potential alternative to conventional deep brain stimulation (DBS). The precise neuroanatomical relationships between DBS targets and the vascular system, however, are poorly characterized to date.ObjectiveTo establish the relationships between cerebrovascular system and DBS targets and investigate the feasibility of endovascular stimulation as an alternative to DBS.MethodsNeuroanatomical targets as employed during deep brain stimulation (anterior limb of the internal capsule, dentatorubrothalamic tract, fornix, globus pallidus pars interna, medial forebrain bundle, nucleus accumbens, pedunculopontine nucleus, subcallosal cingulate cortex, subthalamic nucleus, and ventral intermediate nucleus) were superimposed onto probabilistic vascular atlases obtained from 42 healthy individuals. Euclidian distances between targets and associated vessels were measured. To determine the electrical currents necessary to encapsulate the predefined neurosurgical targets and identify potentially side-effect inducing substrates, a preliminary volume of tissue activated (VTA) analysis was performed.ResultsSix out of ten DBS targets were deemed suitable for endovascular stimulation: medial forebrain bundle (vascular site: P1 segment of posterior cerebral artery), nucleus accumbens (vascular site: A1 segment of anterior cerebral artery), dentatorubrothalamic tract (vascular site: s2 segment of superior cerebellar artery), fornix (vascular site: internal cerebral vein), pedunculopontine nucleus (vascular site: lateral mesencephalic vein), and subcallosal cingulate cortex (vascular site: A2 segment of anterior cerebral artery). While VTAs effectively encapsulated mfb and NA at current thresholds of 3.5 V and 4.5 V respectively, incremental amplitude increases were required to effectively cover fornix, PPN and SCC target (mean voltage: 8.2 ± 4.8 V, range: 3.0–17.0 V). The side-effect profile associated with endovascular stimulation seems to be comparable to conventional lead implantation. Tailoring of targets towards vascular sites, however, may allow to reduce adverse effects, while maintaining the efficacy of neural entrainment within the target tissue.ConclusionsWhile several challenges remain at present, endovascular stimulation of select DBS targets seems feasible offering novel and exciting opportunities in the neuromodulation armamentarium. 相似文献
35.
36.
Spinal cord stimulation (SCS) is widely used for pain relief in patients with failed back surgery syndrome (FBSS), and muscle weakness is a common finding in patients with chronic pain. We present here a single case report of a 47‐year‐old woman, who, after SCS for FBSS, had continuous improvement in lower leg muscle strength and gait, but only transient and minimal pain relief. To the authors’ knowledge, this is only the second published case report of significant improvement in “motor” function, independent of the analgesic effect following SCS in FBSS. If SCS, in fact, does improve muscle strength, new strategies for the management of patients with chronic pain might be opened up. Further studies are needed to verify this hypothesis. 相似文献
37.
Paolo Mazzone Fabrizio Stocchi Salvatore Galati Angelo Insola Maria Grazia Altibrandi Nicola Modugno Domenicantonio Tropepi Livia Brusa Alessandro Stefani 《Neuromodulation》2006,9(3):221-228
Objectives. Traditional deep brain stimulation (DBS) at the subthalamic nucleus (STN) has proved to be efficacious on core Parkinsonian symptoms. However, very disabling l ‐dopa–induced abnormal involuntary movements (AIMs) and axial signs are slightly affected, suggesting that we target less conventional targets. Our candidates for DBS were the globus pallidus internus (GPi) plus the intralaminar thalamic complex (Pf or CM), given its extensive functional links with basal ganglia nuclei. Materials and Methods. The routine utilization of our innovative stereotactic apparatus allows us to implant, at the same time, both the CM‐Pf complex together with the GPi in six Parkinson disease patients. Both intraoperative and postoperative neurophysiologic assessments helped us recognize functional subregions while optimizing implantation of electrodes. Unified Parkinson disease rating scale (UPDRS) motor scores, AIMs, and freezing were carefully blindly evaluated for each condition. Results. A significant amelioration of UPDRS scores was achieved by simultaneous activation of both targets. CM‐Pf activation was only slightly effective in reducing rigidity and akinesia, but more efficacious on freezing. Not surprisingly, AIMs were peculiarly decreased by the activation of the permanent electro‐catheter in the posteroventral GPi. Conclusions. These findings confirm that, in selected patients, it is conceivable to target structures other than the conventional STN in order to maximize clinical benefit. 相似文献
38.
趾蹼血管分型的临床认识 总被引:2,自引:2,他引:0
目的分析120例足趾移植再造手指病例,对趾蹼间的血管形态和交通情况进行观察,并阐述其临床意义。方法临床观察120例156侧趾蹼,对第一跖骨背动脉和第一趾底动脉在趾蹼间的走向、口径以及两者的交通支情况进行记录并进行分型。结果按孙博的分型方法:Ⅰ型72侧,占46.2%;Ⅱ型57侧,占36.5%;Ⅱ型7侧,占4.5%;Ⅳ型3侧,占1.9%;Ⅴ型15侧,占9.6%;另有2侧(占1.3%)第一跖骨背血管口径〉1mm,虽发出趾背动脉供养蹲趾胫侧和第二趾腓侧,但在趾蹼内与趾底血管无吻合,故称之为孙博Ⅵ型。结论(1)从解剖形态看应增加孙博Ⅵ型较全面;(2)从临床实用角度出发,趾蹼间血管可以简单分为三型:Ⅰ型交通支口径在0.5mm以上。Ⅱ型交通支在0.5mm以下。Ⅲ型无交通;(3)手术中采用第一套或第二套供血系统,首先要看趾蹼间血管的交通支,即按本组的分型属Ⅰ型采用第一套供血系统,Ⅱ、Ⅲ型采用第二套供血系统。 相似文献
39.
Role of intracortical mechanisms in the late part of the silent period to transcranial stimulation of the human motor cortex 总被引:3,自引:0,他引:3
J.P. Brasil-Neto A. Cammarota J. Valls-Solé A. Pascual-Leone M. Hallett L. G. Cohen 《Acta neurologica Scandinavica》1995,92(5):383-386
Transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (TES) of the human motor cortex produce a silent period (SP) following motor evoked potentials (MEPs). The early part of the SP can be explained by decreased alpha motor neuron excitability, whereas the late part is presumably due to suprasegmental mechanisms. In order to determine the level of the suprasegmental contribution to the generation of SPs, we recorded excitatory and inhibitory responses to TMS, TES, and percutaneous electrical brainstem stimulation (PBS) in the voluntarily activated first dorsal interosseous muscle of the hand. Stimulus intensities were set so that PBS and TES induced MEPs with areas equal to or larger than those of MEPs obtained with TMS. This procedure revealed that SPs were 49% and 83% shorter with TES and PBS, respectively, than with TMS. As TMS is more effective than TES or PBS in activating cortical interneurons, these findings support the idea that a significant component of the SP arises from intracortical mechanisms. 相似文献
40.
A new implantable bladder volume-monitoring device based on the impedance measurement of the detrusor muscle is described.
The system is completely autonomous and forms a mixed-signal (analogue/digital) feedback loop with a neuro-stimulator to rectify
bladder dysfunctions (incontinence and retention) through neuromuscular stimulation techniques. A programmable instrumentation
amplifier and a signal processing block, to eliminate the artefacts caused by the patient’s movements, have been designed
and tested. The layout for the signal processing block has been realised in 0.8 μm BiCMOS technology. 相似文献