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101.
Mohamed A. Ibrahim Gamal M. Zayed Fahd M. Alsharif Wael A. Abdelhafez 《Saudi Pharmaceutical Journal》2019,27(2):182-190
In this study, we aimed to optimize theophylline pellet formulations using a two-factor three-level full-factorial design (32) by monitoring the concentration of two pellet excipients, polyvinyl pyrrolidone K30 (PVP) binder solution (X1) and the hydrophilic excipient mannitol (X2). Their impact on pellet characteristics (responses) were evaluated. Increasing PVP concentration in the binder solution resulted in an increase in the wet mass torque value. The effect of mannitol, however, was antagonistic. Moreover, the pellet particle size was significantly influenced by the level of mannitol, PVP solution, and quadratic effect of mannitol. Mannitol significantly antagonized the pellet particle size. Furthermore, increased mannitol concentrations significantly enhanced drug dissolution rate from the pellets, whereas PVP concentration in the binder solution significantly reduced the drug dissolution rate. In conclusion, wet granulations can be controlled by monitoring the composition of the binder solution and pellet composition. 相似文献
102.
103.
目的:观察两种不同的荷包缝合方法在吻合器痔上黏膜环切术(procedure for pro-lapse and hemorrhoids,PPH)中的效果。方法采用改良单荷包缝合法或双荷包双圈缝合法对80例Ⅲ、Ⅳ度痔患者行PPH术,并比较两组的平均手术时间、切除黏膜宽度及完整性、痔团回缩效果、吻合口出血、术后并发症、复发等数据。结果切除环形黏膜的完整性、痔回缩效果、平均住院时间及复发情况两组间差异无统计学意义(P>0.05),但双荷包组切除黏膜宽度优于改良单荷包组(P<0.05),平均手术时间、吻合口出血情况改良单荷包组优于双荷包组(P <0.05);术后疼痛、水肿、切口出血、肛门不适感或狭窄等并发症均差异无统计学意义(P>0.05),但双荷包组中更容易发生术后首次排便出血的情况(P<0.05)。结论对于一般中重度痔患者,采用改良单荷包缝合可以达到良好的治疗效果并明显缩短手术时间,但对于痔团脱出严重的患者仍建议使用双荷包缝合以求切除足够的痔上黏膜,起到更明显的悬吊效果。 相似文献
104.
目的:评价关节镜下缝合固定对合并有外侧半月板移位的早期膝关节骨性关节炎(OA)的治疗效果。方法对8例术前 MRI 检查及术中证实的合并外侧半月板外移的早期膝关节OA 患者进行关节镜下外侧半月板的缝合固定,观察术后治疗效果并进行随访,随访时复查膝关节X 光片观察膝关节 OA 病情进展情况,采用 Lysholm 评分评价手术疗效。结果患者平均随访30个月,术后复查膝关正侧位 X 光片,未见骨性关节炎进展征象。术后膝关节 Lysholm 评分显著高于术前(P <0.05),疗效满意。结论对合并移位的膝关节外侧半月板进行缝合固定,有利于恢复半月板正常功能,可能延缓骨性关节炎的发展。 相似文献
105.
目的用三维有限元方法分析扩弓时上颌复合体应力蓄积至腭中缝完全断裂过程的力学特点,并验证模型有效性。方法建立包含种植钉的上颌复合体有限元模型。设定腭中缝屈服强度,以每5 ms加载0.25 mm水平横向位移为载荷,加载至腭中缝完全断裂,同时以临床1例种植钉辅助扩弓患者扩弓前后CT影像结果进行对比验证。结果 0~17 ms,腭中缝应力主要蓄积于腭骨水平板、种植钉周围、腭中缝中后方及颧颌缝; 18~60 ms,腭中缝中后部出现裂纹并向前后扩展; 61~71 ms,腭中缝中后部、前部、后部依次发生断裂。结论基于断裂力学的种植钉辅助扩弓的三维有限元模型有效,其计算的断裂过程结果更符合临床实际。研究结果为今后更有效研究种植钉辅助扩弓提供力学参考模型。 相似文献
106.
背景:手术治疗肱骨大结节骨折目前普及切开复位钢板螺钉固定,但存在着一些不足。目的:比较切开复位带线锚钉与切开复位钢板内固定治疗肱骨大结节骨折的疗效。方法:回顾性分析2016年1月至2018年12月苏州大学附属第一医院收治的肱骨大结节骨折33例患者的资料,根据内固定方式分为锚钉组(n=7)和钢板组(n=26),分别行切开复位带线锚钉和切开复位钢板螺钉内固定。统计比较2组患者手术时间、切口长度、术中失血量、术后骨折块再移位距离及术后1个月、3个月、末次随访肩关节功能Constant-Murle评分,并记录2组内固定的不良反应情况。结果与结论:①锚钉组手术时间(73.1±10.5)min短于钢板组(98.2±11.9)min,切口长度(7.3±1.1)cm小于钢板组(14.9±1.7)cm,术中失血量(45.0±7.1)m L小于钢板组(141.0±25.9)mL,差异均有显著性意义(P<0.05);②锚钉组术后骨折块再移位距离(3.0±1.8)mm大于钢板组(1.1±2.3)mm,差异有显著性意义(P<0.05);③术后1,3个月及末次随访时,2组之间Constant-Murle评分比较,差异均无显著性意义(P>0.05);④提示与切开复位钢板内固定相比,切开复位带线锚钉内固定治疗肱骨大结节骨折具有手术时间短、创伤小的优势。 相似文献
107.
108.
Vaginal cancer is a rare disease of the lower genital tract. We present the case of a 54-year-old woman with occult vaginal cancer after hysterectomy for cervical intraepithelial neoplasia (CIN) III. Despite persistently negative cytology and colposcopy results, a lesion was finally detected by vagino-recto-abdominal examination and she underwent radical parametrectomy and lymph node dissection. We consider the possibility that transabdominal suturing of the vaginal cuff after hysterectomy may reduce the ability to detect subsequent vaginal lesions, and discuss the benefits of a vaginal suture approach. We recommend that suturing the vagina apex transvaginally instead of transabdominally would benefit patients during follow-up. 相似文献
109.
《Journal of pediatric urology》2014,10(2):284-288
ObjectiveAbsorbable staples facilitate detubularization and reconfiguration of the bowel when performing augmentation colocystoplasty. We compared the outcomes of stapled sigmoid augmentation with standard sutured colocystoplasty.Materials and methodsBetween 2003 and 2011, 108 children underwent bladder augmentation at our institution. Colocystoplasty was used in 30 patients (27.8%). Medical charts of children who underwent stapled (n = 8) or sutured (n = 22) sigmoid augmentation were compared with regard to patient demographics and surgical complications, including anastomotic leak and urolithiasis.ResultsEight children with underwent stapled sigmoid colocystoplasty. Average age at surgery was 8 years (range 4–17 years). Time to detubularize and refashion the bowel segment prior to augmentation was consistently under 5 min. Average length of follow-up was 44 months (range 12–80 months). One patient experienced anastomotic leak. Two of eight children (25%) in the stapled anastomosis cohort developed bladder stones. Twenty-two patients underwent standard sigmoid augmentation during the same time period (average age 8.2 years; range 4–16 years). One of 22 (4.5%) experienced anastomotic leak. Seven of 22 (31.8%) developed cystolithiasis.ConclusionsComplications from stapled sigmoid anastomosis are similar to those from standard colocystoplasty. Use of absorbable staples decreases operating time by avoiding bowel spatulation and suturing, and should be considered in pediatric patients undergoing colocystoplasty. 相似文献
110.
《International journal of oral and maxillofacial surgery》2014,43(1):46-61
The aim was to systematically review the maxillary incisor exposure and upper lip position changes with Le Fort I type osteotomies for advancement ± impaction with rigid internal fixation, taking into account the use of cinch sutures and VY closures. Electronic databases (Cochrane Library, Medline, Embase, and Web of Science) were searched using medical subject headings (MeSH), key words, truncations, and Boolean operators. Hand searching was also undertaken. Of 979 articles identified, 15 were included (11 retrospective, two prospective, and two unspecified). Relevant study details and outcomes were recorded on a spreadsheet, along with an assessment of their quality. In total, these studies assessed 419 patients (266 female, 118 male) with a mean age of 26.4 years (range 14–57 years). Soft tissue changes were assessed on lateral cephalometric radiographs. The mean maxillary hard tissue advancement and impaction ranged between 0.94 and 8.77 mm and −0.56 and 4.2 mm, respectively. The ranges of ratios demonstrated that from pronasale (0.24–0.35) to labrale superius (0.36–1.43), the soft tissues followed the underlying horizontal hard tissue movement increasingly more closely. Alar base cinch sutures and VY closures tended to increase these ratios. The soft tissue response was more variable vertically. None of the studies reported on maxillary incisor exposure change. More good quality prospective studies are needed. 相似文献