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81.
A. Pianetti L. Salvaggio M.R. Biffi W. Baffone F. Bruscolini S. de Donato A. Albano 《European journal of epidemiology》1997,13(6):725-727
The serum -tocopherol levels were determined in a group of 182 patients with hematological neoplasms: 87 lymphoid or myeloid leukemias, 65 lymphomas and 30 myelomas. The levels did not differ from those of controls, when compared either globally or for diagnosis. Low -tocopherol serum levels were observed in 6 patients (3.3%). 相似文献
82.
Joseli Lannes-Vieira Jochen Gehrmann Georg W. Kreutzberg Hartmut Wekerle 《Acta neuropathologica》1994,87(5):435-442
We have investigated the T cell receptor (TCR) repertoire in the inflammatory infiltrates of T line-transferred experimental autoimmune encephalomyelitis (EAE) of the Lewis rats. Using a panel of TCR V-specific monoclonal antibodies (mAbs) and immunocytochemistry, we studied the nature of the T cells entering the central nervous system (CNS) after transfer of either myelin basic protein (MBP)-reactive, or MBP-reactive but non-encephalitogenic T cell lines. All the MBP-specific T cell lines predominantely used the V8.2 TCR chain. T cell lines specific for the tuberculin purified protein derivative (PPD), using TCR V genes different from V8.2, served as controls. We first studied the time course of T cells entering the CNS. In all recipient rats, small, but significant numbers of -TCR-expressing infiltrate cells appeared in the CNS within the first 24 h after T cell transfer. In animals injected with either type of MBP-reactive T cells, the early infiltrate cells were preferentially located within the parenchyma of the spinal cord, while in PPD T lineinjected rats, the lymphocytes were mostly found in the meninges. TCR V gene usage was examined on the peak of clinical disease. Six days after T cell transfer, the TCR repertoire used by infiltrating lymphocytes in general seemed to be highly diverse. None of the V isotypes examined (i.e. V8.2, V8.5 or V10) was used by a major population of the -TCR-positive T cells. A more detailed, quantitative analysis of individual infiltrate compartments revealed, however, a preferential accumulation of V8.2-positive T cells within the parenchyma. In contrast, perivascular infiltrating cells used V genes randomly. Our results confirm first that activated T lymphocytes enter the brain rapidly irrespective of their antigen specificity. Second, the data show that most of the perivascular infiltrate T cells in the acute EAE lesion are host-derived, recruited presumably from the recirculating T cell pool, while the encephalitogenic, V8.2-positive T cells preferentially persist within the parenchyma.Abbreviations
EAE
experimental autoimmune encephalomyelitis
-
MBP
myelin basic protein
-
TCL
T cell line
Supported by the Brazilian Research Council (CNPq) 相似文献
83.
本文作者对汕头卫生检疫局1993年从19129名入出境人员疾病监测体检中发现的1809名HBsAg阳性者进行HBV标志物(抗-HBs、HBeAg、抗-HBe、抗-HBc)测定结果的分析,提出今后继续加强开展乙型肝炎“二对半”检测,做好乙型肝炎预防工作的意见。 相似文献
84.
上海市徐汇区性病流行特征及其分析 总被引:1,自引:0,他引:1
的探讨徐汇区性病流行特征及其趋势。方法对徐汇区1989~1997年的性病报告资料进行分析。结果1989~1997年,徐汇区的性病流行呈现高速、持续和中速增长三个时期,1989~1991年平均增长75.63%;1992~1994年平均增长21.66%;1995~1997年平均递增50.18%。淋病为优势病种;1995年以前20~39岁为高发年龄段,1995年以后,20~44岁为高发年龄段;文化层次较低者发病数较多;工人和经商者发病率较高;新生儿和儿童淋病明显增多;梅毒的发病数在逐年增加,呈现出高速增长态势。结论性病防治工作的重点是加强性病防治机构建设,实行匿名就诊,加强对高危人群监测和重点行业人群的宣传教育。 相似文献
85.
福建省鼠伤寒沙门氏菌病原学特征变迁趋势 总被引:1,自引:0,他引:1
目的:了解福建省鼠伤寒沙门氏菌的病原学特征变迁情况。方法:采用噬菌体分型、质粒谱分析及耐药性测定的方法,对福建省1980~1995年15年鼠伤寒沙门氏菌的病原学特征进行动态监测。结果:福建省鼠伤寒沙门氏菌的噬菌体流行型别存在明显的变迁与更迭;质粒谱型有逐渐增多且分散趋势;菌株耐药率逐年大幅度上升,耐药谱逐年迅速增宽,多重耐药菌株逐年急剧增多,耐药现象日趋严重。结论:噬菌体分型、质粒谱分析及耐药性测定是监测福建省鼠伤寒沙门氏菌病原学特征变迁趋势的有效方法。 相似文献
86.
目的:探讨糖皮质激素治疗流行性乙型脑炎的疗效。方法:采用地塞米松针剂加入液体静脉滴注,并配合物理降温、镇静止痉、脱水、给氧、扩容、纠酸、防治感染,加强护理等常规综合治疗。结果:治愈69例(908%),好转3例(39%),死亡4例(53%)。结论:在常规综合治疗基础上应用激素治疗乙型脑炎疗效显著提高。 相似文献
87.
T.O. Lawoyin N.A. Ogunbodede E.A.A. Olumide M.O. Onadeko 《European journal of epidemiology》1999,15(4):365-368
The changing epidemiology of cholera in Ibadan, Nigeria, has become a public health challenge, and outbreaks of the disease have been occurring with increasing frequency since the first outbreak in modern times in 1970. In this outbreak, 1384 persons were seen, diagnosed and treated for the disease at the cholera unit, Ibadan from January to December 1996. The outbreak lasted for a whole year. No child under one year was seen. The age adjusted case fatality rate was 5.3%. Diarrhoea and vomiting were the most common combination of symptoms present in 97.3% of all cases, followed by diarrhoea, vomiting and dehydration (84.3%). The median number of days spent on admission was only 2 days. Cholera cases were clustered within the densely populated and poorly planned areas of the city. Though significantly more cases were seen during the rainy season than during the dry season (p < 0.01), the deaths were not seasonally related (p = 0.67). Contamination of otherwise potable sources of water, late presentation to the cholera treatment unit and low levels of knowledge about diseases need to be addressed in order to effectively control this disease in the community. Progress should also be made towards developing a suitable vaccine for the control of this internationally important public health disease so that the responsibility of its control is not left entirely to individuals and communities, particularly in developing countries. 相似文献
88.
Quentin CD Tondrow M Vogel M 《Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft》1999,96(2):92-96
Background: Persistent and recurrent nummuli after epidemic keratokonjunktivitis (EKC) often lead to reduced visual acuity and increased
glare. In spite of long-term topical steroid therapy nummuli often recur. We tried to treat persistent nummuli with phototherapeutic
keratectomy (PTK).
Patients: PTK with an excimer laser (193 nm) was performed in 13 eyes of 9 patients with nummuli. The nummuli were observed over 3–72
months (mean: 36 months). Preoperatively, the visual acuity was 0.1–0.9 (mean: 0.39 ± 0.22) and the brightness acuity test
(BAT) was 0.05–0.5 (mean: 0.25 ± 0.15). Prior to PTK all eyes had been treated with local steroids several times for recurrent
nummuli.
Results: During the follow-up from 15 to 56 months (mean: 33 ± 11.5 ms), 11 eyes had an increase in visual acuity: 0.3–1.0 (mean:
0.63 ± 0.26). The reduction of glare was especially beneficial for the patients: 0.3–0,9 (mean: 0.55 ± 0.21). One patient
had a recurrence of nummuli in both eyes 6 weeks after PTK. The subjective-induced spheric refractive change was − 2.5 D to
+ 2.0 D. The astigmatic error changed between − 2.0 D to + 1.5 D.
Conclusion: PTK seems to be an effective method of treating persistent, recurrent nummuli after EKC. The low rate of recurrence of nummuli
after PTK is remarkable.
相似文献
89.
1999至2001年广州地区临床常见肠杆菌科细菌耐药性监测结果分析 总被引:5,自引:1,他引:5
目的 了解临床分离常见肠杆菌科细菌的耐药性。方法 统一采用纸片扩散法进行实验,以美国NCCLS文件为判断标准,每次监测均有质控数据。结果 共有11家广州市三级甲等医院实验室参加耐药性监测,三年共统计临床常见肠杆菌科细菌3147株。结论 对肠杆菌科细菌,亚胺培南的耐药率最低,可考虑为临床首选药物,阿米卡星、头孢他啶耐药率相对较低,可选择用药。庆大霉素的耐药率有逐年下降的趋势,将来可能成为临床一线药。而磺胺甲噁唑/甲氧苄啶、四环素、萘啶酸等耐药率相对较高,应慎用。氨节西林的耐药率很高,应避免使用。 相似文献
90.