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41.
应用免疫组化方法完成了胰岛素样生长因子(IGF-I)在48例人前列腺增生中的组织定位。组织经4%甲醛固定,石蜡包埋。IGF-I免疫反应主要定位于腺体基底层上皮细胞浆内,阳性染色也见于腺体分泌上皮、鳞状化生上皮、平滑肌细胞和神经纤维细胞内。证实:IGF-I存在于前列腺增生患者的前列腺组织中,并且与前列腺增生的发病有一定关系。 相似文献
42.
Reversible and irreversible airway inflammation and fibrosis in mice exposed to inhaled ovalbumin 总被引:1,自引:0,他引:1
Objective and design: We examined the reversibility of several changes in the lungs and airways of mice immediately after exposure to ovalbumin aerosol and after a period of recovery breathing clean air.Methods: Mice were exposed for 1, 2, 4, 6, 8, or 10 weeks, with recovery in clean air for 1–3 weeks.Results: Airway collagen content, exhaled NO, airway mucous cell hyperplasia, and lung lavage inflammatory cell content increased upon exposure to ovalbumin aerosol. All parameters except airway fibrosis decreased partially or completely to control values with recovery in clean air.Conclusions: Airway mucous cell hypertrophy and hyperplasia appear to be completely reversible after recovery in clean air, while exhaled NO and airway inflammation appear to be mostly reversible, except for persistence of lymphocytes in the lung lavage fluid. Airway fibrosis appears to be reversible when mice are exposed to ovalbumin aerosol for periods of up to 4 weeks of exposure, but becomes irreversible after 6 or more weeks of exposure.Received 30 June 2004; returned for revision 24 September 2004; accepted by J. S. Skotnicki 13 October 2004 相似文献
43.
PK刀在腹腔镜下早期子宫恶性肿瘤手术中的应用 总被引:1,自引:1,他引:0
目的探讨等离子刀(PK刀)在腹腔镜下广泛子宫切除术和盆腔淋巴结切除术治疗子宫恶性肿瘤中的应用价值。方法2003年1月~2006年12月,应用PK刀行腹腔镜下广泛子宫切除术和盆腔淋巴结切除术治疗30例经活检证实的早期子宫恶性肿瘤,其中子宫颈癌19例,子宫内膜癌11例。结果30例均在腹腔镜下完成手术,无一例中转开腹手术。手术时间(253.2±55.3)min,术中出血量(310.0±147.7)ml,淋巴结切除时间(73.5±23.6)min,淋巴结切除(17.0±6.2)枚,术后肛门排气时间(32.3±11.2)h,术后应用抗生素时间(5.5±1.5)d,术后住院(12±5)d。术中损伤膀胱1例,术后最高体温≥38.5℃3例,尿潴留4例,淋巴囊肿1例。结论PK刀作为兼备切割和止血的腹腔镜手术器械,其止血效果好,创伤小,具有较高的安全性,在子宫恶性肿瘤腹腔镜下行广泛子宫切除术和盆腔淋巴结切除术是安全、可行的。 相似文献
44.
经尿道前列腺电汽化联合撬拨术治疗高龄前列腺增生症 总被引:2,自引:1,他引:1
目的探索微创手术治疗高龄前列腺增生症(benign prostatic hyperlasia,BPH)的安全有效新方法. 方法采用经尿道前列腺电汽化(transurethal vaporiyation of prostate,TUVP)联合撬拨术治疗80岁以上BPH 68例. 结果手术时间30~160 min,平均60 min,切除腺体重量12.5~98.5 g,平均37.6 g,术中出血量30~120 ml,平均65 ml,术后住院5~7 d,平均6 d.术后随访0.5~2年,国际前列腺症状评分由(23.5±4.2)分降至(6.5±2.1)分,生活质量评分由(4.6±0.6)分降至(2.2±0.2)分,最大尿流率由(8.7±4.3)ml/s升至(18.0±2.2)ml/s,剩余尿由(176.0±86.7)ml降至(12.2±2.4)ml.与术前相比,术后6个月均得到显著改善(P<0.01). 结论 TUVP加撬拨术治疗高龄BPH安全有效,并发症少. 相似文献
45.
目的:对良性前列腺增生(BPH)合并慢性前列腺炎的发病情况进行分析和探讨。方法:对213例已确诊为BPH患者进行前列腺按摩液(EPS)常规检查及EPS细菌培养,支原体、衣原体检测和血清PSA检测。对合并慢性前列腺炎的患者,进行抗炎治疗前后的BPH症状评分(IPSS)比较。结果:213例BPH患者中,合并慢性前列腺炎69例(32.4%),EPS细菌培养阳性27例(12.7%),EPS支原体、衣原体检测,15例阳性(7.0%)。合并慢性前列腺炎的患者中有7例PSA异常(>4μg/L)。69例合并慢性前列腺炎的患者经抗炎治疗后,IPSS由治疗前(12.2±2.6)分,降为治疗后(10.5±2.3)分,差异有显著性(P<0.01)。结论:BPH患者进行EPS检查,以明确是否合并有慢性前列腺炎,对临床上明确诊断、选择治疗药物或手术方式,提高疗效及减少并发症都有着重要意义。 相似文献
46.
宫腔镜在绝经后妇女子宫内膜病变中的诊治价值 总被引:8,自引:1,他引:7
目的探讨宫腔镜在绝经后子宫内膜病变中的诊治价值。方法回顾性分析2002年1月~2006年11月行官腔镜诊治的107例绝经后子宫内膜病变患者的临床资料,包括绝经后不规则阴道出血68例,B超检查子宫内膜增厚无阴道出血39例。并对手术时间、术中出血、并发症、术后病理和随访结果进行分析。结果106例顺利完成宫腔镜下检查及治疗,1例子宫穿孔,保守治愈。手术时间15~60min,(26.8±9.5)min,出血量10~60ml,(30.2±18.3)ml。术后病理结果:子宫内膜息肉69例(64.5%),黏膜下子宫肌瘤18例(16.8%),子宫内膜不典型增生12例(11.2%),子宫内膜癌2例(1.9%),正常子宫内膜6例(5.6%)。90例(84.1%)术后随访3~12个月,(6.0±3.8)月,其中8例子宫内膜息肉复发,再次宫腔镜手术治疗。结论官腔镜检查是绝经后子宫内膜病变首选的检查方法,可直视下观察子宫内膜的形态变化并取活检送病理;官腔镜治疗可以完整切除子宫内膜息肉、子宫黏膜下肌瘤等子宫内膜良性病变。 相似文献
47.
48.
Seethalakshmi Viswanathan Naveen Chawla Anil D’Cruz Shubhada V. Kane 《Head and neck pathology》2007,1(2):169-172
Histoplasmosis is a rarely reported deep mycotic infection in the Indian context. Oral or oropharyngeal manifestation can
occur as an isolated symptom or as part of a disseminated process associated with immunosuppression especially with HIV and
diabetes. Five cases of head and neck histoplasmosis accrued over 6 years in a tertiary referral cancer institute were reviewed.
All these patients presented clinically as cancer. In three patients, the marked pseudoepitheliomatous hyperplasia led to
a mistaken biopsy diagnosis of malignancy following which definitive surgical treatment was performed. The subsequent excision
revealed typical features of histoplasmosis. Isolated oral presentation of histoplasmosis can mimic malignancy both clinically
as well as pathologically, leading to potentially disastrous consequences. A high index of suspicion in those with overt or
hidden immunosuppression and a deep wedge biopsy to demonstrate the organisms in the subepithelial tissue is recommended.
This work has been presented in the “Slide seminar on Infections and Infestations” in the IAP-ID pre conference CME in APCON
2006. 相似文献
49.
50.
C Gurkan Zorlu Tayup Simsek Eylem Seker Ari 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2005,9(4):442-446
OBJECTIVE: The aim of this study was to evaluate the feasibility of laparoscopy in the management of early stage endometrial cancer. METHODS: Fifty-two patients with endometrial cancer who underwent surgical staging consisting of total hysterectomy, bilateral salpingo-oophorectomy with pelvic lymph node dissection, and cytology between 1998 to 2002 were included in the study. Laparotomy and laparoscopy were randomly offered to patients upon admittance. RESULTS: Of 52 patients, 26 underwent laparotomy and the remaining 26 underwent laparoscopic staging surgery. No significant difference existed between the demographic characteristics of the 2 groups. The mean number of harvested lymph nodes was 18.2 in the laparoscopic group and 21.1 in the laparotomic group (P>0.05). Pelvic lymph node metastases were detected in 7.7% of the patients in the laparoscopy group and 15.4% in the laparotomy group, and the difference was not significant. Adjuvant radiotherapy was applied later to 42.3% of the laparoscopy group and 38.5% of the laparotomy group. Operative morbidity was higher in the laparotomy group mainly because of postoperative wound infection, and the patients in the laparotomy group had a longer hospital stay. CONCLUSION: Laparoscopic surgery is a method that can be applied as well as laparotomy in the management of endometrial cancer. Lymph node number and detection of lymph node metastasis did not differ significantly in laparotomic and laparoscopic approaches. Wound infections were more frequent in laparotomies. 相似文献