冠心病患者血脂异常与胰岛素抵抗的关系

目的 :探讨冠心病患者血脂异常与胰岛素抵抗的关系。方法 :观察 68例冠心病患者与 66例对照者的血脂、血糖、胰岛素等生化指标 ,以胰岛素释放指数———空腹胰岛素 (FIns) /空腹血糖 (FBG)和胰岛素敏感指数(1 /FBG×FIns)作为胰岛素抵抗 (IR)的指标 ,与空腹血脂进行直线相关分析。结果 :冠心病组与对照组对比 ,血糖水平无明显差异 (P >0 .0 5) ,而血胰岛素、胰岛素释放指数明显较对照组增高 (P <0 .0 5) ,胰岛素敏感指数明显较对照组低 (P <0 .0 5)。冠心病组的甘油三酯 (TG)、总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL -C)明显较对照组增高 (P <0 .0 5)、高密度脂蛋白胆固醇 (HDL -C)明显较对照组低 (P <0 .0 5)。冠心病组胰岛素释放指数、胰岛素敏感指数分别与TG ,TC和LDL -C呈正相关 ,与HDL -C呈负相关。结论 :冠心病患者存在着高胰岛素血症和胰岛素抵抗 ,而且冠心病患者的胰岛素抵抗和血脂异常密切相关。     

喉症丸鉴定方法的研究

对不同批号喉症丸的二阶导数紫外谱线组图谱进行了测绘分析，发现不同批号的喉症丸其四溶剂二阶导数紫外吸收光谱特征数据，λmax或λsh具有很好的重现性，其分辨率高，特征性强，因此，以二阶导数紫外谱线组法控制喉症丸质量，鉴别喉症丸真伪优劣具有良好的重现性和准确性。     

正常闪光视网膜电图的频域分析

应用快速傅里叶转换技术对正常视网膜电图进行频域分析，发现其ａ、ｂ波的优势频及能量集中在５－７５Ｈｚ；与ＯＰＳ波的分离点为７７ＨＺ，从而提出单纯记录ａ、ｂ波及ＯＰＳ波各自的较理想的通频带。     

汽车驾驶员心电多相频谱分析

对１１７例汽车司机应用ＨＢＤ－１心电多信息诊断仪进行心电多相频谱分析，其功率谱，传递相移，幅度直方图等五项指标总分阳性率明显高于对照组，随着驾车年限的增加，总分阳性率有升高趋势，心电频谱分析对２３０例冠心病病人阳性检出率８４．７８％。研究认为汽车司机是易发高血压，冠心病的危险人群，该方法在冠心病的环境流行病学研究中具有重要的临床，亚临床意义。     

宝鸡市城市饮用水与人群健康效应的调查研究

本文通过对宝鸡市居民饮自来水和自备井水的人群进行了回顾性和前瞻性调查分析，结果发现，饮自来水与饮未经处理自备井水明显的差异。即调查组（饮自来水）肠道传染病发病率为４．２２％和６．８２％，对照组（饮自备井水）发病率为７．７１％和１１．５６％经卡方检验Ｐ＜０．０５，差异有显著性。从发病病种来看，调查组和对照组均以腹泻为主，其次为痢疾和肝炎，发病率分别是：腹泻，调查组为３５．５９‰和６３．００‰，对照组     

乳液聚合型品红成色剂的应用性能

测试了3种新型L-品红成色剂的应用性能。结果表明：与母体品红成色剂相比，L-品红成色剂能显著地减少在蓝光区的有害吸收；与工业用油溶性品红成色剂Ns相比，L-品红成色剂的一些照相性能更加优越。     

Spatial frequency content of the Cardiff and related acuity tests

In the Cardiff acuity test, simple pictures on an otherwise neutral grey card are defined by borders consisting of a relatively broad white band flanked by black bands each half the width of the white band. Higher levels of acuity correspond to the ability to detect figures defined by narrower borders, the figure size remaining constant. It is sometimes implied that the acuity limit corresponding to each card can be equated with different levels of grating resolution, the total width of the border corresponding to the overall grating period. It is shown that although the spatial frequency spectra of the Cardiff figures, like those of other vanishing optotypes, lack very low-frequency components, they have a complex two-dimensional form. The figures have wide spatial bandwidth and no well-defined discrete frequency components. As a result, the relationship between measured Cardiff and grating acuity will vary somewhat, depending upon the particular optical, neural or other deficits of the individual being tested.     

Acute effects of high-dose thyrotropin releasing hormone infusions in Alzheimer's disease

Thyrotropin releasing hormone (TRH) was administered intravenously to ten patients with Alzheimer's Disease (AD) in a high-dose paradigm, thought to maximize central nervous system effects and potentially produce facilitation of cholinergic function, a known property of the neuropeptide. Acute effects of TRH on behavioral, cognitive and physiologic measures were assessed after patients received 0.1 mg/kg TRH, 0.3 mg/kg TRH and placebo, the higher TRH dose and placebo being given in a randomized, double-blind fashion. Patients showed statistically significant increases in arousal and improvement in affect, as well as a modest improvement in semantic memory, all after receiving the higher TRH dose. Both TRH doses produced transient rises in systolic blood pressure, with no effect on diastolic blood pressure, heart rate or temperature. This study suggests that high-dose TRH can be safely administered to AD patients and is neurobehaviorally active; further studies are needed to determine the extent and mechanism of the cognitive and psychobiological properties of this peptide in AD and other neuropsychiatric disorders.