Ecotropic and dualtropic mink cell focus-inducing murine leukemia viruses can induce a wide spectrum of H-2 controlled lymphoma types

Neonatal infection of C57BL and BALB/c mice by cloned ecotropic and dualtropic mink cell focus-inducing (MCF) murine leukemia viruses (MuLV) induces a wide spectrum of different lymphomas of T, B, and non-T/non-B cell types. Oncogenic dualtropic MCF viruses and poorly oncogenic ecotropic MuLV act synergistically in lymphomagenesis. Within one mouse strain virus-induced T-cell lymphomas arise earlier than B-cell lymphomas after neonatal inoculation of a single-cloned MuLV. The host genetic constitution, notably the H-2 complex has a marked influence on lymphoma type. This H-2 influence can be explained by an H-2-linked difference in penetration of the thymus early in life by oncogenic thymotropic MuLV, which in turn is correlated with, but not necessarily due to the magnitude of the anti-MuLV antibody response.     

伯氏疟原虫对青蒿素抗药性的研究

仿Peters剂量递增法用伯氏疟原虫ANKA株及N株对QHS进行了抗药性的研究。经14个月的培育至第58代,QHS im注射“4日抑制性实验”的ED₅₀在RQ/ANKA系及RQ/N系分别为其亲代系的53.4及54.6倍,但经蚊传未获成功。在第40代(I₅₀=25)时,其50%的治愈剂量为其亲代系的5.4倍。停药传代其抗性会逐渐消失。该虫系对青蒿酯钠及蒿甲醚有明显的交叉抗性,其ED₅₀分别为其亲代系的13.1及11.7倍,对伯喹的抗性为2.9倍,对氯喹未见明显交叉抗性。     

云南省跨境婚姻家庭艾滋病、梅毒和乙肝检测现状分析

目的 了解云南省中-缅、中-老、中-越跨境婚姻家庭艾滋病、梅毒和乙肝检测情况,为完善跨境婚姻家庭预防母婴传播相关服务政策提供科学依据。 方法 对目前居住在云南省边境地区的中国籍和跨境婚姻家庭进行调查和访谈,收集一般人口学特征、最近一次怀孕期间三病检测情况等信息。经整理后,使用构成比和率对指标进行计算,使用卡方检验、秩和检验比较中国籍和跨境婚姻家庭各项检测服务状况。 结果 外籍媳妇主要以农民、文盲/小学、无经济收入的少数民族为主。配偶检测率,老挝籍低于当地中国籍媳妇（〖XC五号.EPS;P〗=7.87,P=0.005）,缅甸籍、越南籍与当地中国籍没有差异;缅甸籍高于老挝籍和越南籍（〖XC五号.EPS;P〗=41.84,P＜0.001）。三病检测点知晓率,缅甸籍媳妇低于当地中国籍媳妇（〖XC五号.EPS;P〗=6.11,P＜0.03）,越南籍、老挝籍与当地中国籍没有差异;老挝籍高于缅甸籍和越南籍（〖XC五号.EPS;P〗=44.03,P＜0.001）。获得预防母婴传播相关知识比例,三个外籍媳妇均低于当地中国籍（〖XC五号.EPS;P〗=19.84,P＜0.001;〖XC五号.EPS;P〗=7.52,P=0.006;〖XC五号.EPS;P〗=4.38,P=0.036）。 结论 边境地区针对跨境婚姻家庭开展艾滋病、梅毒和乙肝预防母婴传播相关工作取得实效,三病检测情况与当地中国籍基本一致,但在其他服务利用上仍存在一定差距,外籍媳妇孕早期三病检测率及其配偶检测率、相关预防母婴传播知识获取还有待提升,需要运用更加有效的服务管理模式来促进三病检测可及性的进一步提高。     

恒力法测量运动对动物肌腱,韧带横截面积的影响

本文介绍一种方便，适用的肌腱，韧带横截面积的测量工具－软组织横截面积测微计。通过对兔屈趾肌腱反复测量，其重复性精密度在０．０４４ｍｍ以内，变异系数在１．４％以下，用该测微计对大强度训练一段时间后的兔屈趾肌腱，跟腱和膝内侧副韧带的测量发现，训练训练后ＦＤＰ，ＡＣ的横截面积减小，ＭＣＬ有增大的趋势，据此，作用认为肌腱的变化与长期大强度训练后试件的“疲劳蠕变”有关，ＭＣＬ的变化则与在体内的负荷形式有关。     

恒力法测量制动对兔髌韧带截面面积的影响

目的：介绍一种测量软组织截面面积的装置和方法。方法：用测微仪对膝关节制动前后兔髌韧带截面面积进行反复测量。结果：测微仪的变异系数在０．９％以下,制动６周后髌韧带的截面面积明显增大。结论：兔髌韧带截面面积的这种变化与组织的胶原代谢水平相关     

Ischemic "cross" tolerance in hypoxic ischemia of immature rat brain

The phenomenon of ischemic tolerance has been closely associated with the expression of heat shock proteins but recently, stress tolerance not related to hsp72 has been reported. In the present study, we focused on ischemic tolerance induced by hypoxia and hyperthermia in neonatal rat brain and analyzed the expression of hsp72. In a neonatal rat model of hypoxic ischemia (H-I), preconditioning by whole-body hyperthermia or hypoxia was induced 24 h prior to the ischemia. Brain damage was histologically evaluated and the expressions of hsp72 were analyzed. Hyperthermic preconditioning at 41 degrees C for 15 min, as well as hypoxic preconditioning with 8% hypoxia for 3 h, had almost complete neuroprotective effects. However, we failed to detect the expression of hsp72 in any of preconditioning. Only the H-I insult itself induced hsp72 in the dorsal striatum and slightly in the thalamus and the hippocampus. Hyperthermic preconditioning has neuroprotective effects which are comparable to hypoxic preconditioning in immature brain. The expression of hsp72 is not likely necessary for the ischemic tolerance in immature brain.     

血库在安全输血中的重要性

为了全面发展安全输血事业，除了血液中心或血站与此有非常重要的关系外，血库也是一个极其重要的环节。本文从配血样本的严格把关；技术操作的规范化；科学合理用血；记录与核对；输血前的病毒检验几术方面阐述了安全血液与血库的关系，强调血库的重要性，以全方位保证临床输血安全。     

缪刺考

At present, most physicians hold that Miu Ci is "left and right cross collateral prick-ing",but it does not conform to the original meaning of "Suwen·Miucilunpian"(Plain Questions ·Trea-tise on Miu Ci). Miucilanpian holds that Miu Ci is the extension and perfection of Ju Ci (contralateral me-ridian needling), which mainly pricks the collateral but is not limited to the collateral, as it also pricks the acupuncture point. As for the "left and right cross" point selection, it is one step in the procedure of the treatment in the process of contralateral collateral needling instead of being a principle.     

湖南省9县市人群钩端螺旋体抗体水平分析

目的试图从9县市人群钩端螺旋体抗体水平探析钩体主要流行群和隐性与显性感染比例。方法选择以前钩体病发病率较高的9县市中无钩体疫苗接种史的10～65岁常住村民1240人作为对象，于流行高峰前采取外周静脉血，按国家标准方法做显微镜凝集试验（MAT）测15群15型钩体抗体；用SPSS统计软件进行统计学分析。结果9县13群钩体抗体的阳性率和隐性感染率差异有统计学意义的分别有9群（黄疸出血、拜伦、澳洲、流感伤寒、波摩那、秋季、犬群、七日热和曼耗）和3群（黄疸出血、澳洲和波摩那）。交叉阳性率差异亦有统计学意义，最高为湘潭（80．39％）、最低为南县（36．17％）。黄疸出血群隐感率最高为湘潭（38．24％）、最低系岳阳（1．60％）。以黄疸出血群抗体滴度1：≥80为标准推测隐性感染与显性感染比例为53700：1；以≥320为标准，则为11500：1。结论不同县市钩体主要流行群不同，但以黄疸出血群为主；推荐黄疸出血群钩体隐性感染抗体滴度以1：≥200为宜，隐性与显性感染比例约为3万分之一；本地区钩体将以散发为主，流行的概率较小。