国内外期刊评价检索体系的选刊原则与评价标准

本文对国内外较为知名的期刊评价与检索体系选刊原则及其评价标准做系统综述,为科研工作者了解相关体系提供信息,同时也为期刊进入相关的评价与检索体系提供准则.     

骨与软组织肿瘤穿刺活检技术

目的探讨穿刺活检的技术及方法。方法自1994年1月至2004年12月共有1304例骨与软组织肿瘤患者在我院接受治疗,通过分析术前穿刺活检病理与术后病理的相关性,研究穿刺活检的技术特点及影响穿刺活检准确性的因素及改进方法。结果将术前穿刺病理及术后病理的相关性分为三种:正确、支持、阴性。1304例穿刺活检,正确918例(69.4%),支持346例(26.2%),阴性57例(4.4%)。结论穿刺活检是损伤小、操作简便的获取病理诊断的方法,在影像学检查的指导下可完成复杂部位的活检,具有很高的准确率。     

The advanced lung cancer inflammation index predicts outcomes of patients with non-small cell lung cancer following video-assisted thoracic surgery

ObjectiveThe advanced lung cancer inflammation index (ALI) predicts overall survival (OS) in patients with advanced lung cancer. However, few studies have tested ALI’s prognostic effect in patients with non-small cell lung cancer (NSCLC) following video-assisted thoracic surgery (VATS), especially patients at stage III. This study investigated the relationship between ALI and outcomes of patients with NSCLC following VATS.MethodsWe retrospectively examined 339 patients with NSCLC who underwent VATS at Hebei General Hospital, China. Preoperative clinical and laboratory parameters were collected and analyzed. Optimal cutoff values of potential prognostic factors, including ALI, were determined. Kaplan–Meier and Cox regression analyses were used to determine each factor’s prognostic value.ResultsThe median OS was 31 months. The optimal cutoff value for ALI was 41.20. Patients with high ALI (≥41.20) displayed increased OS (33.87 vs. 30.24 months), higher survival rates, and milder clinical characteristics. Univariate and multivariate analyses showed a significant correlation between ALI and the prognosis of patients with NSCLC, including those at stage IIIA, who underwent VATS.ConclusionsLow ALI correlated with poor outcomes in patients with NSCLC following VATS. Preoperative ALI might be a potential prognostic biomarker for patients with NSCLC following VATS, including patients at stage IIIA.     

自拟利湿行水方合穴位埋线治疗非酒精性脂肪性肝病疗效观察

目的观察自拟利湿行水方合穴位埋线治疗非酒精性脂肪性肝病疗效及对影像学指标的影响。方法将2016年3月—2017年12月广东省中山市中医院收治的94例非酒精性脂肪性肝病患者随机分为2组,对照组47例依据《非酒精性脂肪性肝病防治指南》进行西医对症治疗,观察组47例则在此基础上加用自拟利湿行水方合穴位埋线治疗,比较2组治疗前后体质量指数(BMI)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、肝/脾CT比值及肝脏B超病变程度分级,并比较2组疗效。结果2组治疗后ALT、AST、TC、TG及LDL-C水平均显著降低(P均<0.05),HDL-C、肝/脾CT比值均显著提高(P均<0.05),且观察组治疗后以上指标均显著优于对照组(P均<0.05);2组治疗后肝脏B超病变严重程度分级均显著改善(P均<0.05),且观察组改善情况显著优于对照组(P<0.05)。观察组和对照组总有效率分别为80.8%(38/47)和95.7%(45/47),观察组客观疗效显著优于对照组(P<0.05)。结论自拟利湿行水方合穴位埋线治疗非酒精性脂肪性肝病可有效提高病情控制效果,减轻肝功能损伤,调节血脂指标,并有助于缓解临床症状,优于单纯西医疗法。     

颈椎椎间盘髓核内压力测试分析研究

颈椎椎间盘是维持颈段脊柱的重要组成部分,它在维持颈椎稳定性方面起着非常重要的作用,但各种原因导致颈椎椎间盘退变或突发引起一系列的临床病症。本文通过人体全段颈椎标本模拟人体中立位生理载荷运动,建立力学模型,并用直接和间接的方法测定颈椎椎间盘髓核内压力的数据子以验证,为颈椎椎间盘研究提供相应的生物力学评价和理论依据。     

患者术前临床特征对嗜酸性粒细胞型慢性鼻窦炎伴鼻息肉的预测价值

目的 探讨患者的术前临床特征对嗜酸性粒细胞型慢性鼻窦炎伴鼻息肉(ECRSwNP)的预测价值,并构建用于临床实践的诺模图。方法 选取2019年9月—2020年9月就诊于新乡医学院第一附属医院并行功能性鼻内镜手术治疗的慢性鼻窦炎伴鼻息肉(CRSwNP)患者97例,根据术后病理结果嗜酸性粒细胞(EOS)浸润程度将其分为ECRSwNP组和非嗜酸性粒细胞型慢性鼻窦炎伴鼻息肉(nonECRSwNP)组,收集并比较两组患者的临床特征资料,采用单因素及多因素二元Logistic回归分析筛选对ECRSwNP有预测价值的术前特征资料,并构建用于临床实践的诺模图。采用SPSS 26.0和R语言软件4.1.2对数据进行分析。结果 两组患者在是否合并哮喘史、外周血嗜酸性粒细胞(EOS)计数、外周血嗜碱性粒细胞(Baso)计数、日本难治性嗜酸性慢性鼻窦炎流行病学调查(JESREC)评分、上颌窦评分、前后组筛窦评分、CT总分、E/M(筛窦与上颌窦的Lund-Mackay评分比值)上差异具有统计学意义(P<0.05)。单因素及多因素二元Logistic回归分析并构建的诺模图显示,基于哮喘史、外周血EOS、外周血...     

复合树脂核材料的弯曲强度性能研究

目的:采用三点弯曲实验的方法测量3种复合树脂核材料的弯曲强度。方法:本实验使用的3种复合树脂核材料分别为DCFlowCore、Bisfil-Core和LuxaCore。每种材料各制作6个大小为(2.0±0.1)mm×(3.0±0.1)mm×(25.0±0.1)mm的矩形试件。试件在Instron万能材料测试机上测试其弯曲强度,跨距为(20.0±0.1)mm,加载速度为0.5mm/min,使用单因素方差分析对测量数据进行统计学检验。结果:3种材料的弯曲强度值分别为:DCFlowCore(137.96±9.48)MPa,Bisfil-Core(123.82±12.99)MPa,LuxaCore(110.11±10.03)MPa。统计检验的结果显示,DCFlowCore与Bisfil-Core之间(P<0.041)、DCFlowCore与LuxaCore之间(P<0.001)、Bisfil-Core与LuxaCore之间(P<0.047)均有显著性差异。结论:从本实验的结果来看,3种核材料的弯曲强度均可以满足临床需要,以DCFlowCore的弯曲强度值最高。     

抗-HBe阳性乙型肝炎病毒C基因启动子和前C基因变异

研究抗 -HBe阳性乙型肝炎病毒C基因启动子 (CP)和前C基因变异。用基因序列分析检测基因变异。(1)抗 -HBe阳性患者的前C终止变异 (nt1896G→A)的发生率显著高于抗 -HBe阴性组 (P <0 0 0 1) ;而CP双变异(nt176 2A→T和 176 4G→A)则在两组中无明显差异。 (2 )同抗 -HBe阳性慢性乙肝组比较 ,抗 -HBe阳性重型乙肝患者的前C终止变异和CP双变异发生率无明显差异 ,而CPnt175 2A→G变异发生率则显著增高 (P <0 0 5 )。前C终止变异与抗 -HBe阳性乙型肝炎密切相关 ;而CPnt175 2变异则可能与抗 -HBe阳性重型乙型肝炎发病有关     

Lobular involvement: Prognostic indicator for invasive ductal carcinoma of the breast

One of the striking microscopic appearances of breast carcinoma is malignant transformation of the epithelium of an entire lobule, although the lobular architecture is still preserved. We termed this pathological feature 'lobular involvement'. An investigation was carried out to determine whether lobular involvement would be a useful prognostic indicator for invasive ductal carcinoma. One hundred and fifty cases of invasive ductal carcinoma were included in this study. The lobular involvement, as well as the conventional prognostic factors, was evaluated to find out the correlation with the overall and relapse-free survivals by univariate and multivariate analyses. The lobular involvement was identified in 31 of 150 patients (20.6%). Of the patients with lobular involvement, two had experienced recurrence (6.5%) and one had died (3.2%). The lobular involvement and lymph node metastases were significantly and independently correlated with the overall and relapse-free survivals. The presence of lobular involvement was statistically correlated with the favorable outcome. Lobular involvement can be assumed as a new prognostic indicator for invasive ductal carcinoma.     

Impact of p53 immunostaining in predicting advanced or recurrent placental site trophoblastic tumors: a study of 12 cases

OBJECTIVES: To identify an indicator that can predict tumor cell spread beyond the uterine corpus. METHODS: We studied clinicopathology and immunohistochemistry of 12 cases of PSTT. Two cases of epithelioid trophoblastic tumor (ETT) were included as reference cases. For immunohistochemistry, antibodies against Ki-67, p53, human chorionic gonadotropin (hCG), human placental lactogen (hPL), carcinoembryonic antigen (CEA, polyclonal antibodies; pCEA), carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1), and bcl-2 were used. PSTT cases were divided as confined and non-confined groups (CG and NCG, respectively). CG consisted of stage I cases with no evidence of recurrence during the follow-up, while NCG consisted of either advanced (stage II or higher) or recurrent stage I lesions. RESULTS: Age, the interval from the latest pregnancy, serum hCG/hPL levels, tumor size, mitotic figures, Ki-67 labeling indices, and bcl-2 did not discriminate NCG from CG. CEACAM1 and CEA-related antigens as determined by polyclonal anti-CEA antibodies were specifically stained in PSTT cells, but they could not discriminate groups. p53 was positive in PSTT cells in NCG (6/6, 100%), while it was positive in only one case of CG (1/6, 16.7%), indicating a possible usefulness of p53 immunostaining in predicting an invasive or recurrent propensity of PSTT cells (p=0.015). CONCLUSIONS: This finding also suggests the importance of p53 function in the biology of PSTT cells.